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BTK [cytosol]
Stable Identifier
R-BTA-197948
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
Q3ZC95
Locations in the PathwayBrowser
Expand all
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Signaling by the B Cell Receptor (BCR) (Bos taurus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Bos taurus)
BTK binds BTK inhibitors (Bos taurus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Bos taurus)
BTK:PIP3 [plasma membrane] (Bos taurus)
BTK [cytosol] (Bos taurus)
BTK:BTK inhibitors [plasma membrane] (Bos taurus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Bos taurus)
BTK:PIP3 [plasma membrane] (Bos taurus)
BTK [cytosol] (Bos taurus)
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Bos taurus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Bos taurus)
BTK:PIP3 [plasma membrane] (Bos taurus)
BTK [cytosol] (Bos taurus)
BTK [cytosol] (Bos taurus)
Innate Immune System (Bos taurus)
DAP12 interactions (Bos taurus)
DAP12 signaling (Bos taurus)
Activation of RAC1 by VAV2/3 (Bos taurus)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Bos taurus)
BTK [cytosol] (Bos taurus)
Recruitment of VAV and BTK to p-SLP-76 (Bos taurus)
BTK [cytosol] (Bos taurus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Bos taurus)
BTK [cytosol] (Bos taurus)
Fc epsilon receptor (FCERI) signaling (Bos taurus)
FCERI mediated Ca+2 mobilization (Bos taurus)
Phosphorylation of TEC kinases by p-SYK (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Bos taurus)
TEC,BTK,ITK,(TXK) [cytosol] (Bos taurus)
BTK [cytosol] (Bos taurus)
Fcgamma receptor (FCGR) dependent phagocytosis (Bos taurus)
Regulation of actin dynamics for phagocytic cup formation (Bos taurus)
Src phosphorylate WASP,N-WASP (Bos taurus)
Src-kinases [cytosol] (Bos taurus)
BTK [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Signaling by GPCR (Bos taurus)
GPCR downstream signalling (Bos taurus)
G alpha (12/13) signalling events (Bos taurus)
BTK in G alpha (12)-BTK complex is activated (Bos taurus)
G alpha (12):BTK [plasma membrane] (Bos taurus)
BTK [cytosol] (Bos taurus)
G alpha (12) binds BTK (Bos taurus)
BTK [cytosol] (Bos taurus)
G alpha (12):BTK [plasma membrane] (Bos taurus)
BTK [cytosol] (Bos taurus)
G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Bos taurus)
BTK [cytosol] (Bos taurus)
G alpha (12):BTK [plasma membrane] (Bos taurus)
BTK [cytosol] (Bos taurus)
G alpha (q) signalling events (Bos taurus)
Active Gq binds BTK (Bos taurus)
Active Gq:BTK [plasma membrane] (Bos taurus)
BTK [cytosol] (Bos taurus)
BTK [cytosol] (Bos taurus)
BTK in active Gq-BTK complex is activated (Bos taurus)
Active Gq:BTK [plasma membrane] (Bos taurus)
BTK [cytosol] (Bos taurus)
Gq-BTK complex dissociates to Active BTK and Gq (Bos taurus)
Active Gq:BTK [plasma membrane] (Bos taurus)
BTK [cytosol] (Bos taurus)
BTK [cytosol] (Bos taurus)
G-protein beta:gamma signalling (Bos taurus)
G beta:gamma signalling through BTK (Bos taurus)
BTK in PIP3:BTK:G beta-gamma complex is activated (Bos taurus)
PIP3:BTK:G-protein beta-gamma complex [plasma membrane] (Bos taurus)
BTK [cytosol] (Bos taurus)
G beta-gamma complex and PIP3 recruit BTK to membrane (Bos taurus)
BTK [cytosol] (Bos taurus)
PIP3:BTK:G-protein beta-gamma complex [plasma membrane] (Bos taurus)
BTK [cytosol] (Bos taurus)
PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Bos taurus)
BTK [cytosol] (Bos taurus)
PIP3:BTK:G-protein beta-gamma complex [plasma membrane] (Bos taurus)
BTK [cytosol] (Bos taurus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Bos taurus)
Signaling by Rho GTPases (Bos taurus)
RHO GTPase Effectors (Bos taurus)
RHO GTPases Activate WASPs and WAVEs (Bos taurus)
Src phosphorylate WASP,N-WASP (Bos taurus)
Src-kinases [cytosol] (Bos taurus)
BTK [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:Q3ZC95
Reference Genes
BioGPS Gene:533459
ENSEMBL:ENSBTAG00000019250.4
KEGG:bta:533459
Monarch:533459
NCBI Entrez Gene:533459
UCSC:Q3ZC95
Reference Transcript
RefSeq:XM_005227791.3
RefSeq:NM_001034589.2
Other Identifiers
533459
Bt.26060.1.A1_at
GO:0001818
GO:0002344
GO:0002376
GO:0003824
GO:0004672
GO:0004713
GO:0004715
GO:0005515
GO:0005524
GO:0005547
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0006468
GO:0016004
GO:0016740
GO:0030889
GO:0031410
GO:0032481
GO:0035556
GO:0042802
GO:0043274
GO:0045121
GO:0048469
GO:0050853
GO:0098761
GO:0098772
GO:0140096
GO:0140896
GO:0141111
GO:1900227
Participates
as a component of
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Bos taurus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Bos taurus)
Active Gq:BTK [plasma membrane] (Bos taurus)
G alpha (12):BTK [plasma membrane] (Bos taurus)
PIP3:BTK:G-protein beta-gamma complex [plasma membrane] (Bos taurus)
BTK:PIP3 [plasma membrane] (Bos taurus)
as an input of
Recruitment of VAV and BTK to p-SLP-76 (Bos taurus)
Active Gq binds BTK (Bos taurus)
G alpha (12) binds BTK (Bos taurus)
G beta-gamma complex and PIP3 recruit BTK to membrane (Bos taurus)
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Bos taurus)
as a member of
TEC,BTK,ITK,(TXK) [cytosol] (Bos taurus)
as an output of
Gq-BTK complex dissociates to Active BTK and Gq (Bos taurus)
G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Bos taurus)
PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Bos taurus)
as a candidate of
Src-kinases [cytosol] (Bos taurus)
Other forms of this molecule
phospho-p-Y223,Y551-BTK [cytosol]
phospho-p-Y551-BTK [cytosol]
phospho-p-Y223,Y551-BTK [plasma membrane]
Inferred From
Active BTK [cytosol]
(Homo sapiens)
BTK [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001029761.1
,
XP_005227848.1
ENSEMBL
ENSBTAP00000030121
,
ENSBTAT00000030136
,
ENSBTAG00000019250
VGNC
26601
PDB
4Y94
,
4Y93
,
4Y95
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