Reactome | FCGR1A [plasma membrane]

FCGR1A [plasma membrane]

Stable Identifier

R-BTA-197835

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

plasma membrane

Synonyms

FCGR1A, A0A3S5ZP99

Locations in the PathwayBrowser

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Immune System (Bos taurus)

- Adaptive Immune System (Bos taurus)
  - Class I MHC mediated antigen processing & presentation (Bos taurus)
    - Antigen processing-Cross presentation (Bos taurus)
      - Cross-presentation of soluble exogenous antigens (endosomes) (Bos taurus)
        
        Internalization of receptor bound antigen into clathrin coted vesicles (Bos taurus)
        
        MR:soluble antigen [plasma membrane] (Bos taurus)
        
        MR/other probable receptors [plasma membrane] (Bos taurus)
        
        FCGR1A [plasma membrane] (Bos taurus)
  - Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Bos taurus)
    - NCR3LG1 binds NCR3 (Bos taurus)
      - NCR3:FCRG1A:CD3Z dimer [plasma membrane] (Bos taurus)
        
        FCRG1A:CD3Z dimer [plasma membrane] (Bos taurus)
        
        FCGR1A [plasma membrane] (Bos taurus)
      - NCR3LG1:NCR3:FCRG3A:CD3Z dimer [plasma membrane] (Bos taurus)
        
        NCR3:FCRG1A:CD3Z dimer [plasma membrane] (Bos taurus)
        
        FCRG1A:CD3Z dimer [plasma membrane] (Bos taurus)
        
        FCGR1A [plasma membrane] (Bos taurus)
- Innate Immune System (Bos taurus)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Bos taurus)
    - FCGR activation (Bos taurus)
      - Cross-linking of FCGRIA with IgG-coated Ag (Bos taurus)
        
        FCGRIA:CD3G homodimer [plasma membrane] (Bos taurus)
        
        FCGR1A [plasma membrane] (Bos taurus)
        
        IgG-Ag:FCGRIA:CD3G homodimer [plasma membrane] (Bos taurus)
        
        FCGRIA:CD3G homodimer [plasma membrane] (Bos taurus)
        
        FCGR1A [plasma membrane] (Bos taurus)
      - Recruitment of SYK to phosphorylated ITAMs (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Bos taurus)
        
        p-FCGRs [plasma membrane] (Bos taurus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Bos taurus)
        
        FCGR1A [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs:SYK [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Bos taurus)
        
        p-FCGRs [plasma membrane] (Bos taurus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Bos taurus)
        
        FCGR1A [plasma membrane] (Bos taurus)
      - Sequestering and phosphorylation Fc gamma receptors in the lipid rafts (Bos taurus)
        
        clustered IgG-Ag:FCGRs [plasma membrane] (Bos taurus)
        
        FCGRs [plasma membrane] (Bos taurus)
        
        FCGRIA:CD3G homodimer [plasma membrane] (Bos taurus)
        
        FCGR1A [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Bos taurus)
        
        p-FCGRs [plasma membrane] (Bos taurus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Bos taurus)
        
        FCGR1A [plasma membrane] (Bos taurus)
    - Regulation of actin dynamics for phagocytic cup formation (Bos taurus)
      - Activation of RAC1 by CRKII:DOCK180:ELMO (Bos taurus)
        
        CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Bos taurus)
        
        p-FCGRs [plasma membrane] (Bos taurus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Bos taurus)
        
        FCGR1A [plasma membrane] (Bos taurus)
      - Activation of RAC1 by VAV (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-VAV [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Bos taurus)
        
        p-FCGRs [plasma membrane] (Bos taurus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Bos taurus)
        
        FCGR1A [plasma membrane] (Bos taurus)
      - Phosphorylation of VAV (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Bos taurus)
        
        p-FCGRs [plasma membrane] (Bos taurus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Bos taurus)
        
        FCGR1A [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Bos taurus)
        
        p-FCGRs [plasma membrane] (Bos taurus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Bos taurus)
        
        FCGR1A [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-VAV [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Bos taurus)
        
        p-FCGRs [plasma membrane] (Bos taurus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Bos taurus)
        
        FCGR1A [plasma membrane] (Bos taurus)
      - Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Bos taurus)
        
        CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Bos taurus)
        
        p-FCGRs [plasma membrane] (Bos taurus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Bos taurus)
        
        FCGR1A [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Bos taurus)
        
        p-FCGRs [plasma membrane] (Bos taurus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Bos taurus)
        
        FCGR1A [plasma membrane] (Bos taurus)
      - Recruitment of VAV1 to p-6Y-SYK (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Bos taurus)
        
        p-FCGRs [plasma membrane] (Bos taurus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Bos taurus)
        
        FCGR1A [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Bos taurus)
        
        p-FCGRs [plasma membrane] (Bos taurus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Bos taurus)
        
        FCGR1A [plasma membrane] (Bos taurus)
      - Role of myosins in phagosome formation (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Bos taurus)
        
        p-FCGRs [plasma membrane] (Bos taurus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Bos taurus)
        
        FCGR1A [plasma membrane] (Bos taurus)
    - Role of phospholipids in phagocytosis (Bos taurus)
      - PI3K binds to p-6Y-SYK (Bos taurus)
        
        PI3K:p-6Y-SYK [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Bos taurus)
        
        p-FCGRs [plasma membrane] (Bos taurus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Bos taurus)
        
        FCGR1A [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Bos taurus)
        
        p-FCGRs [plasma membrane] (Bos taurus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Bos taurus)
        
        FCGR1A [plasma membrane] (Bos taurus)
      - PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
        
        PI3K:p-6Y-SYK [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Bos taurus)
        
        p-FCGRs [plasma membrane] (Bos taurus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Bos taurus)
        
        FCGR1A [plasma membrane] (Bos taurus)
      - Phosphorylation and activation of PLCG (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Bos taurus)
        
        p-FCGRs [plasma membrane] (Bos taurus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Bos taurus)
        
        FCGR1A [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Bos taurus)
        
        p-FCGRs [plasma membrane] (Bos taurus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Bos taurus)
        
        FCGR1A [plasma membrane] (Bos taurus)
      - Recruitment of PLCgamma to membrane (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Bos taurus)
        
        p-FCGRs [plasma membrane] (Bos taurus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Bos taurus)
        
        FCGR1A [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Bos taurus)
        
        p-FCGRs [plasma membrane] (Bos taurus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Bos taurus)
        
        FCGR1A [plasma membrane] (Bos taurus)
      - Release of PLCG from FCGR (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Bos taurus)
        
        p-FCGRs [plasma membrane] (Bos taurus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Bos taurus)
        
        FCGR1A [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Bos taurus)
        
        p-FCGRs [plasma membrane] (Bos taurus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Bos taurus)
        
        FCGR1A [plasma membrane] (Bos taurus)

External Reference Information

External Reference

UniProt:A0A3S5ZP99

Gene Names

FCGR1A

Reference Genes

ENSEMBL:ENSBTAG00000008592.6

ENSEMBL:ENSBTAG00000008592.7 FCGR1A

Other Identifiers

282227

Participates

as a component of

as a member of

MR/other probable receptors [plasma membrane] (Bos taurus)

Other forms of this molecule

FCGR1A [clathrin-coated endocytic vesicle membrane]

FCGR1A [early endosome membrane]

Inferred From

FCGRA [plasma membrane] (Homo sapiens)

FCGR1A [plasma membrane] (Homo sapiens)

Cross References

OpenTargets

ENSG00000150337

Ensembl

ENSBTAT00000011333, ENSBTAP00000011333, ENSBTAG00000008592

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