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CREBBP [nucleoplasm]
Stable Identifier
R-BTA-193545
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
nucleoplasm
Synonyms
CREBBP, F1MD32
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
Cellular response to chemical stress (Bos taurus)
Cytoprotection by HMOX1 (Bos taurus)
Fatty acid ligands activate PPARA (Bos taurus)
Coactivators of PPARalpha [nucleoplasm] (Bos taurus)
CREBBP [nucleoplasm] (Bos taurus)
PPARA:RXRA Coactivator complex [nucleoplasm] (Bos taurus)
Coactivators of PPARalpha [nucleoplasm] (Bos taurus)
CREBBP [nucleoplasm] (Bos taurus)
KEAP1-NFE2L2 pathway (Bos taurus)
Nuclear events mediated by NFE2L2 (Bos taurus)
CREBBP, EP300 acetylates NFE2L2 (Bos taurus)
CREBBP,EP300 [nucleoplasm] (Bos taurus)
CREBBP [nucleoplasm] (Bos taurus)
p-AcK-NFE2L2:CREBBP, EP300 [nucleoplasm] (Bos taurus)
CREBBP,EP300 [nucleoplasm] (Bos taurus)
CREBBP [nucleoplasm] (Bos taurus)
p-NFE2L2:CREBBP,EP300 [nucleoplasm] (Bos taurus)
CREBBP,EP300 [nucleoplasm] (Bos taurus)
CREBBP [nucleoplasm] (Bos taurus)
NFE2L2 binds CREBBP,EP300 (Bos taurus)
CREBBP,EP300 [nucleoplasm] (Bos taurus)
CREBBP [nucleoplasm] (Bos taurus)
p-NFE2L2:CREBBP,EP300 [nucleoplasm] (Bos taurus)
CREBBP,EP300 [nucleoplasm] (Bos taurus)
CREBBP [nucleoplasm] (Bos taurus)
Cellular response to heat stress (Bos taurus)
HSF1-dependent transactivation (Bos taurus)
Attenuation phase (Bos taurus)
HSF1 acetylation at Lys80 (Bos taurus)
CREBBP,EP300 [nucleoplasm] (Bos taurus)
CREBBP [nucleoplasm] (Bos taurus)
Cellular response to hypoxia (Bos taurus)
Regulation of gene expression by Hypoxia-inducible Factor (Bos taurus)
Formation of HIF:CBP:p300 complex at promoters (Bos taurus)
CREBBP [nucleoplasm] (Bos taurus)
HIF:CBP:p300 [nucleoplasm] (Bos taurus)
CREBBP [nucleoplasm] (Bos taurus)
Developmental Biology (Bos taurus)
MITF-M-regulated melanocyte development (Bos taurus)
Transcriptional and post-translational regulation of MITF-M expression and activity (Bos taurus)
CREBBP acetylates HINT1 dimer (Bos taurus)
CREBBP [nucleoplasm] (Bos taurus)
HINT1 binds MITF-M (Bos taurus)
CREBBP [nucleoplasm] (Bos taurus)
Gene expression (Transcription) (Bos taurus)
RNA Polymerase II Transcription (Bos taurus)
Generic Transcription Pathway (Bos taurus)
FOXO-mediated transcription (Bos taurus)
Regulation of FOXO transcriptional activity by acetylation (Bos taurus)
CREBBP binds FOXO1 (Bos taurus)
CREBBP [nucleoplasm] (Bos taurus)
FOXO1:CREBBP [nucleoplasm] (Bos taurus)
CREBBP [nucleoplasm] (Bos taurus)
Notch-HLH transcription pathway (Bos taurus)
Formation of CSL-NICD coactivator complex (Bos taurus)
CREBBP [nucleoplasm] (Bos taurus)
CSL NICD coactivator complex [nucleoplasm] (Bos taurus)
CREBBP [nucleoplasm] (Bos taurus)
Transcriptional regulation by RUNX1 (Bos taurus)
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells (Bos taurus)
RUNX1:CBFB binds CREBBP (Bos taurus)
CREBBP [nucleoplasm] (Bos taurus)
RUNX1:CBFB:CREBBP [nucleoplasm] (Bos taurus)
CREBBP [nucleoplasm] (Bos taurus)
Transcriptional regulation by RUNX3 (Bos taurus)
RUNX3 regulates NOTCH signaling (Bos taurus)
RUNX3 binds the NOTCH1 coactivator complex (Bos taurus)
NOTCH1 Coactivator Complex [nucleoplasm] (Bos taurus)
CREBBP [nucleoplasm] (Bos taurus)
RUNX3:NOTCH1 Coactivator Complex [nucleoplasm] (Bos taurus)
NOTCH1 Coactivator Complex [nucleoplasm] (Bos taurus)
CREBBP [nucleoplasm] (Bos taurus)
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors (Bos taurus)
Activation of the TFAP2 (AP-2) family of transcription factors (Bos taurus)
TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP (Bos taurus)
CREBBP [nucleoplasm] (Bos taurus)
TFAP2 homo- and heterodimers:CITED2,CITED4,(CITED1):EP300:CREBBP [nucleoplasm] (Bos taurus)
CREBBP [nucleoplasm] (Bos taurus)
Immune System (Bos taurus)
Innate Immune System (Bos taurus)
C-type lectin receptors (CLRs) (Bos taurus)
CD209 (DC-SIGN) signaling (Bos taurus)
CBP and p300 binds NF-kB complex (Bos taurus)
CREBBP,EP300 [nucleoplasm] (Bos taurus)
CREBBP [nucleoplasm] (Bos taurus)
NFKB1:p-S276-RELA:p300/CBP [nucleoplasm] (Bos taurus)
CREBBP,EP300 [nucleoplasm] (Bos taurus)
CREBBP [nucleoplasm] (Bos taurus)
p300 acetylates RELA subunit (Bos taurus)
CREBBP,EP300 [nucleoplasm] (Bos taurus)
CREBBP [nucleoplasm] (Bos taurus)
NFKB1:p-S276,5AcK-RELA:p300/CBP [nucleoplasm] (Bos taurus)
CREBBP,EP300 [nucleoplasm] (Bos taurus)
CREBBP [nucleoplasm] (Bos taurus)
NFKB1:p-S276-RELA:p300/CBP [nucleoplasm] (Bos taurus)
CREBBP,EP300 [nucleoplasm] (Bos taurus)
CREBBP [nucleoplasm] (Bos taurus)
Cytosolic sensors of pathogen-associated DNA (Bos taurus)
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production (Bos taurus)
Beta-catenin enhances association of IRF3 with CBP/p300 (Bos taurus)
CREBBP,EP300 [nucleoplasm] (Bos taurus)
CREBBP [nucleoplasm] (Bos taurus)
beta-catenin:IRF3:p300 [nucleoplasm] (Bos taurus)
CREBBP,EP300 [nucleoplasm] (Bos taurus)
CREBBP [nucleoplasm] (Bos taurus)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Bos taurus)
TRAF6 mediated IRF7 activation (Bos taurus)
Formation of VAF (virus-activated factor) complex (Bos taurus)
CREBBP,EP300 [nucleoplasm] (Bos taurus)
CREBBP [nucleoplasm] (Bos taurus)
VAF (virus-activated factor) [nucleoplasm] (Bos taurus)
CREBBP,EP300 [nucleoplasm] (Bos taurus)
CREBBP [nucleoplasm] (Bos taurus)
p-IRF7 dimer interacts with coactivator CBP/p300 (Bos taurus)
CBP/p300:pIRF7:pIRF7 [nucleoplasm] (Bos taurus)
CREBBP,EP300 [nucleoplasm] (Bos taurus)
CREBBP [nucleoplasm] (Bos taurus)
CREBBP,EP300 [nucleoplasm] (Bos taurus)
CREBBP [nucleoplasm] (Bos taurus)
Metabolism (Bos taurus)
Metabolism of lipids (Bos taurus)
Regulation of lipid metabolism by PPARalpha (Bos taurus)
Fatty acid ligands activate PPARA (Bos taurus)
Coactivators of PPARalpha [nucleoplasm] (Bos taurus)
CREBBP [nucleoplasm] (Bos taurus)
PPARA:RXRA Coactivator complex [nucleoplasm] (Bos taurus)
Coactivators of PPARalpha [nucleoplasm] (Bos taurus)
CREBBP [nucleoplasm] (Bos taurus)
Signal Transduction (Bos taurus)
Signaling by Nuclear Receptors (Bos taurus)
ESR-mediated signaling (Bos taurus)
Estrogen-dependent gene expression (Bos taurus)
GREB1 binds ESR1:ESTG and co-activators (Bos taurus)
CREBBP [nucleoplasm] (Bos taurus)
GREB1:ESR1:ESTG:EP300:CREBBP [nucleoplasm] (Bos taurus)
CREBBP [nucleoplasm] (Bos taurus)
Signaling by WNT (Bos taurus)
TCF dependent signaling in response to WNT (Bos taurus)
Formation of the beta-catenin:TCF transactivating complex (Bos taurus)
Beta-catenin recruits CBP/p300 (Bos taurus)
CREBBP,EP300 [nucleoplasm] (Bos taurus)
CREBBP [nucleoplasm] (Bos taurus)
TCF/LEF:CTNNB1:CBP/p300 [nucleoplasm] (Bos taurus)
CREBBP,EP300 [nucleoplasm] (Bos taurus)
CREBBP [nucleoplasm] (Bos taurus)
External Reference Information
External Reference
UniProt:F1MD32
Gene Names
CREBBP
Reference Genes
BioGPS Gene:505453 CREBBP
ENSEMBL:ENSBTAG00000026403.5
ENSEMBL:ENSBTAG00000026403.6 CREBBP
KEGG Gene (Bos taurus):505453 CREBBP
Monarch:505453 CREBBP
NCBI Gene:505453 CREBBP
Reference Transcript
RefSeq:NM_001164022.1 CREBBP
Other Identifiers
GO:0000122
GO:0000123
GO:0000785
GO:0001223
GO:0002039
GO:0003677
GO:0003682
GO:0003684
GO:0003712
GO:0003713
GO:0003714
GO:0003824
GO:0004402
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0005737
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0008270
GO:0016407
GO:0016479
GO:0016604
GO:0016740
GO:0016746
GO:0023052
GO:0030511
GO:0031490
GO:0031648
GO:0031669
GO:0034644
GO:0036211
GO:0038061
GO:0043226
GO:0043229
GO:0043426
GO:0043993
GO:0044017
GO:0044877
GO:0045893
GO:0045944
GO:0046872
GO:0048511
GO:0050896
GO:0061629
GO:0061733
GO:0140096
GO:0140110
GO:0140297
GO:1900182
Participates
as an input of
GREB1 binds ESR1:ESTG and co-activators (Bos taurus)
CREBBP binds FOXO1 (Bos taurus)
RUNX1:CBFB binds CREBBP (Bos taurus)
TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP (Bos taurus)
Formation of CSL-NICD coactivator complex (Bos taurus)
Formation of HIF:CBP:p300 complex at promoters (Bos taurus)
as a component of
GREB1:ESR1:ESTG:EP300:CREBBP [nucleoplasm] (Bos taurus)
FOXO1:CREBBP [nucleoplasm] (Bos taurus)
RUNX1:CBFB:CREBBP [nucleoplasm] (Bos taurus)
TFAP2 homo- and heterodimers:CITED2,CITED4,(CITED1):EP300:CREBBP [nucleoplasm] (Bos taurus)
CSL NICD coactivator complex [nucleoplasm] (Bos taurus)
HIF:CBP:p300 [nucleoplasm] (Bos taurus)
NOTCH1 Coactivator Complex [nucleoplasm] (Bos taurus)
as a member of
CREBBP,EP300 [nucleoplasm] (Bos taurus)
Coactivators of PPARalpha [nucleoplasm] (Bos taurus)
This entity regulates
Negatively
HINT1 binds MITF-M
(Bos taurus)
Inferred From
CREBBP [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_001157494.1
OpenTargets
ENSG00000005339
Ensembl
ENSBTAT00000005092
,
ENSBTAP00000005092
,
ENSBTAG00000026403
VGNC
27698
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