Reactome | SRC-2 [cytosol]

SRC-2 [cytosol]

Stable Identifier

R-BTA-191648

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

E1BIM8

Locations in the PathwayBrowser

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Developmental Biology (Bos taurus)

- Axon guidance (Bos taurus)
  - EPH-Ephrin signaling (Bos taurus)
    - EPH-ephrin mediated repulsion of cells (Bos taurus)
      - EPHA binds TIAM1 (Bos taurus)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Bos taurus)
        
        SRC,FYN,YES,LYN [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
        
        EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Bos taurus)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Bos taurus)
        
        SRC,FYN,YES,LYN [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
      - SFKs phosphorylate VAV2,3 (Bos taurus)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Bos taurus)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Bos taurus)
        
        SRC,FYN,YES,LYN [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Bos taurus)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Bos taurus)
        
        SRC,FYN,YES,LYN [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
        
        SRC,FYN,YES,LYN [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
      - TIAM1 exchanges GTP for GDP on RAC1, activating it (Bos taurus)
        
        EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Bos taurus)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Bos taurus)
        
        SRC,FYN,YES,LYN [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
      - VAV exchanges GTP for GDP on RAC1, activating it (Bos taurus)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Bos taurus)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Bos taurus)
        
        SRC,FYN,YES,LYN [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
      - p-EPHs bind VAV2,3 (Bos taurus)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Bos taurus)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Bos taurus)
        
        SRC,FYN,YES,LYN [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Bos taurus)
        
        SRC,FYN,YES,LYN [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
    - EPHA-mediated growth cone collapse (Bos taurus)
      - NGEF exchanges GTP for GDP on RHOA (Bos taurus)
        
        EFNAs:p-EPHAs:SFKs:p-Y179-NGEF [plasma membrane] (Bos taurus)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Bos taurus)
        
        SRC,FYN,YES,LYN [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
    - EPHB-mediated forward signaling (Bos taurus)
      - EPHB phosphorylates TIAM1 (Bos taurus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane] (Bos taurus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Bos taurus)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Bos taurus)
        
        SRC,FYN,YES,LYN [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:p-Y829-TIAM1 [plasma membrane] (Bos taurus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Bos taurus)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Bos taurus)
        
        SRC,FYN,YES,LYN [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
      - EPHB:NMDAR binds TIAM1 (Bos taurus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Bos taurus)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Bos taurus)
        
        SRC,FYN,YES,LYN [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane] (Bos taurus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Bos taurus)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Bos taurus)
        
        SRC,FYN,YES,LYN [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
      - p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Bos taurus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:p-Y829-TIAM1 [plasma membrane] (Bos taurus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Bos taurus)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Bos taurus)
        
        SRC,FYN,YES,LYN [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
    - Ephrin signaling (Bos taurus)
      - EFNB:GRB4 binds GIT1 (Bos taurus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Bos taurus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Bos taurus)
        
        SRC,FYN [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Bos taurus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Bos taurus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Bos taurus)
        
        SRC,FYN [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
      - EFNBs bind SFKs (Bos taurus)
        
        EPHBs:EFNBs:SRC,FYN [plasma membrane] (Bos taurus)
        
        SRC,FYN [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
        
        SRC,FYN [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
      - GIT1 binds bPIX (Bos taurus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Bos taurus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Bos taurus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Bos taurus)
        
        SRC,FYN [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Bos taurus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Bos taurus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Bos taurus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Bos taurus)
        
        SRC,FYN [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
      - PAK binds RAC and bPIX (Bos taurus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Bos taurus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Bos taurus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Bos taurus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Bos taurus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Bos taurus)
        
        SRC,FYN [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Bos taurus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Bos taurus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Bos taurus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Bos taurus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Bos taurus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Bos taurus)
        
        SRC,FYN [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
      - PAKs autophosphorylate (Bos taurus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Bos taurus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Bos taurus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Bos taurus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Bos taurus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Bos taurus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Bos taurus)
        
        SRC,FYN [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Bos taurus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Bos taurus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Bos taurus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Bos taurus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Bos taurus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Bos taurus)
        
        SRC,FYN [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
      - PAKs phosphorylate MLC (Bos taurus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Bos taurus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Bos taurus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Bos taurus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Bos taurus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Bos taurus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Bos taurus)
        
        SRC,FYN [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
      - bPIX exchanges GTP for GDP on RAC, activating it (Bos taurus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Bos taurus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Bos taurus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Bos taurus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Bos taurus)
        
        SRC,FYN [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Bos taurus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Bos taurus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Bos taurus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Bos taurus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Bos taurus)
        
        SRC,FYN [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
      - p-EFNB binds GRB4 (Bos taurus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Bos taurus)
        
        SRC,FYN [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Bos taurus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Bos taurus)
        
        SRC,FYN [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
  - RET signaling (Bos taurus)
    - 2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Bos taurus)
      - 2x p-5Y-RET:GDNF:GFRA complexes:SRC-1,RAP1GAP [plasma membrane] (Bos taurus)
        
        SRC-1, RAP1GAP [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
      - SRC-1, RAP1GAP [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)

Immune System (Bos taurus)

- Adaptive Immune System (Bos taurus)
  - Costimulation by the CD28 family (Bos taurus)
    - CTLA4 inhibitory signaling (Bos taurus)
      - SHP2 phosphatase binds CTLA-4 (Bos taurus)
        
        p-Y165,Y182-CTLA-4 dimer:SFKs [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
        
        pCTLA-4:Src kinases:SHP2 [plasma membrane] (Bos taurus)
        
        p-Y165,Y182-CTLA-4 dimer:SFKs [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)

Signal Transduction (Bos taurus)

- Signaling by Receptor Tyrosine Kinases (Bos taurus)
  - Signaling by SCF-KIT (Bos taurus)
    - Dimerization of STATs (Bos taurus)
      - p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
      - p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
    - Disassociation and translocation of STATs to the nucleus (Bos taurus)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
      - p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
    - GRB2 is indirectly recruited to p-KIT through SHP2 (Bos taurus)
      - GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
      - p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
    - Indirect recruitment of GAB2 to p-KIT (Bos taurus)
      - GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
      - GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
    - Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Bos taurus)
      - PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
      - p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
    - JAK2 binds to p-KIT (Bos taurus)
      - JAK2:SFKS:p-KIT complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
      - SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
    - Phosphorylation of GAB2 by SFKs (Bos taurus)
      - GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
      - Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
      - p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
    - Phosphorylation of JAK2 (Bos taurus)
      - JAK2:SFKS:p-KIT complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
    - Phosphorylation of SHP2 by SFKs (Bos taurus)
      - SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
      - Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
      - p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
    - Phosphorylation of STATs (Bos taurus)
      - p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
      - p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
    - Phosphorylation of p-KIT on Y900 by Src kinases (Bos taurus)
      - SFKs:p-8Y-KIT:sSCF dimer:p-8Y-KIT [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
      - SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
    - Recruitment of STATs (Bos taurus)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
      - p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
    - Regulation of KIT signaling (Bos taurus)
      - Interaction of APS and p-KIT (Bos taurus)
        
        APS dimer:p-c-Kit:SFKs complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
      - Phosphorylation of APS (Bos taurus)
        
        APS dimer:p-c-Kit:SFKs complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
      - Recruitment of CBL to KIT (Bos taurus)
        
        CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] (Bos taurus)
        
        Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Bos taurus)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
        
        Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Bos taurus)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
    - SHP2 interacts with p-KIT (Bos taurus)
      - SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
      - SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
    - Synthesis of PIP3 from PIP2 by PI3K (Bos taurus)
      - PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
  - Signaling by VEGF (Bos taurus)
    - VEGFA-VEGFR2 Pathway (Bos taurus)
      - Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1 [plasma membrane] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:pS-SHB:p-5Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
      - CRK binds BCAR1 and or PXN (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
      - DOCK180:ELMO binds CRK (Bos taurus)
        
        CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
      - DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Bos taurus)
        
        CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
      - HSP90AA1 binds p-6Y-VEGFR2 (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1 [plasma membrane] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1 [plasma membrane] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
      - PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:PXN [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
      - PXN binds p-6Y,S732-PTK2 (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:PXN [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
      - Phosphorylation of SRC-1 (Bos taurus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A:SRC-1 [plasma membrane] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
      - RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1 [plasma membrane] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
      - SRC-1 binds p-Y397-PTK2 (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1 [plasma membrane] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
      - SRC-1 phosphorylates p-Y397-PTK2 (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1 [plasma membrane] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1 [plasma membrane] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
      - SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A:SRC-1 [plasma membrane] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
      - VEGFR2 mediated cell proliferation (Bos taurus)
        
        SFKs phosphorylate PLCG1 (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
      - p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:pS-SHB:p-5Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Bos taurus)
        
        SRC-2 [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:E1BIM8

Reference Genes

BioGPS Gene:535742

dbSNP Gene:535742

ENSEMBL:ENSBTAG00000008938

KEGG Gene (Bos taurus):535742

Monarch:535742

NCBI Gene:535742

Reference Transcript

Other Identifiers

ENSBTAG00000008938

ENSBTAP00000011767

ENSBTAT00000011767

GO:0000003

GO:0000166

GO:0000902

GO:0002102

GO:0002376

GO:0003013

GO:0003674

GO:0004672

GO:0004713

GO:0004715

GO:0005102

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005737

GO:0005739

GO:0005743

GO:0005764

GO:0005768

GO:0005770

GO:0005773

GO:0005829

GO:0005856

GO:0005884

GO:0005886

GO:0005901

GO:0006259

GO:0006464

GO:0006468

GO:0006810

GO:0006950

GO:0007010

GO:0007155

GO:0007165

GO:0007169

GO:0007173

GO:0007179

GO:0007229

GO:0007267

GO:0008022

GO:0008150

GO:0008219

GO:0009058

GO:0010632

GO:0010634

GO:0010954

GO:0016192

GO:0016301

GO:0016310

GO:0016477

GO:0016740

GO:0018108

GO:0019899

GO:0019900

GO:0019904

GO:0020037

GO:0022407

GO:0022607

GO:0030154

GO:0030900

GO:0031234

GO:0031410

GO:0031648

GO:0032211

GO:0032463

GO:0032587

GO:0032991

GO:0033146

GO:0034446

GO:0034614

GO:0034641

GO:0035556

GO:0036035

GO:0036120

GO:0038083

GO:0040011

GO:0042169

GO:0042592

GO:0043066

GO:0043149

GO:0043154

GO:0043167

GO:0043226

GO:0043393

GO:0044325

GO:0045453

GO:0046777

GO:0046875

GO:0048471

GO:0048477

GO:0048856

GO:0048870

GO:0050731

GO:0050847

GO:0051057

GO:0051219

GO:0051276

GO:0051604

GO:0051897

GO:0051902

GO:0051974

GO:0060065

GO:0060444

GO:0060491

GO:0065003

GO:0070374

GO:0070555

GO:0070851

GO:0071253

GO:0071375

GO:0071498

GO:0071560

GO:0071803

GO:0071902

GO:0086098

GO:0090263

GO:0097110

GO:1900182

GO:2000394

GO:2000641

GO:2000811

GO:2001237

GO:2001243

GO:2001286

IPR000719

IPR000980

IPR001245

IPR001452

IPR008266

IPR011009

IPR017441

IPR020635

IPR036028

IPR036860

PF00017

PF00018

PF07714

PR00109

PR00401

PR00452

SM00219

SM00252

SM00326

SRC-201

VGNC:35269

Participant Of

input

hasComponent

hasMember

Other forms of this molecule

SRC [cytosol]

phospho-p-Y416-SRC [cytosol]

MyrG-SRC [plasma membrane]

phospho-MyrG,p-Y530-SRC [plasma membrane]

SRC-1 [plasma membrane]

phospho-p-Y419-SRC [cytosol]

phospho-MyrG-p-Y419-SRC [plasma membrane]

Inferred From

Activated SRC-1 [cytosol] (Homo sapiens)

SRC-2 [cytosol] (Homo sapiens)

SRC-1 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_010809813.1, NP_001104274.1

BRENDA (Bos taurus)

2.7.10.2