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mature beta-NGF homodimer [extracellular region]
Stable Identifier
R-BTA-187031
Type
Complex
Species
Bos taurus
Compartment
extracellular region
Locations in the PathwayBrowser
Expand all
Signal Transduction (Bos taurus)
Death Receptor Signaling (Bos taurus)
p75 NTR receptor-mediated signalling (Bos taurus)
Cell death signalling via NRAGE, NRIF and NADE (Bos taurus)
NADE modulates death signalling (Bos taurus)
14-3-3epsilon attentuates NADE-related apoptosis (Bos taurus)
NGF ligand:p75NTR:NADE:14-3-3epsilon [plasma membrane] (Bos taurus)
NGF:p75NTR:NADE [plasma membrane] (Bos taurus)
mature NGF homodimer:p75NTR [plasma membrane] (Bos taurus)
mature beta-NGF homodimer [extracellular region] (Bos taurus)
NGF:p75NTR:NADE [plasma membrane] (Bos taurus)
mature NGF homodimer:p75NTR [plasma membrane] (Bos taurus)
mature beta-NGF homodimer [extracellular region] (Bos taurus)
p75NTR binds to NADE (Bos taurus)
NGF:p75NTR:NADE [plasma membrane] (Bos taurus)
mature NGF homodimer:p75NTR [plasma membrane] (Bos taurus)
mature beta-NGF homodimer [extracellular region] (Bos taurus)
mature NGF homodimer:p75NTR [plasma membrane] (Bos taurus)
mature beta-NGF homodimer [extracellular region] (Bos taurus)
p75NTR:NADE promotes caspase2/3 activation (Bos taurus)
NGF:p75NTR:NADE [plasma membrane] (Bos taurus)
mature NGF homodimer:p75NTR [plasma membrane] (Bos taurus)
mature beta-NGF homodimer [extracellular region] (Bos taurus)
NRIF signals cell death from the nucleus (Bos taurus)
TRAF6 binds to p75NTR:NRIF (Bos taurus)
NGF ligand:p75NTR:NRIF [plasma membrane] (Bos taurus)
mature NGF homodimer:p75NTR [plasma membrane] (Bos taurus)
mature beta-NGF homodimer [extracellular region] (Bos taurus)
NGF ligand:p75NTR:NRIF:TRAF6 [plasma membrane] (Bos taurus)
NGF ligand:p75NTR:NRIF [plasma membrane] (Bos taurus)
mature NGF homodimer:p75NTR [plasma membrane] (Bos taurus)
mature beta-NGF homodimer [extracellular region] (Bos taurus)
gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Bos taurus)
NGF ligand:p75NTR:NRIF:TRAF6 [plasma membrane] (Bos taurus)
NGF ligand:p75NTR:NRIF [plasma membrane] (Bos taurus)
mature NGF homodimer:p75NTR [plasma membrane] (Bos taurus)
mature beta-NGF homodimer [extracellular region] (Bos taurus)
mature NGF homodimer:p75NTR [plasma membrane] (Bos taurus)
mature beta-NGF homodimer [extracellular region] (Bos taurus)
NFG and proNGF binds to p75NTR (Bos taurus)
NGF homodimer binds to p75NTR (Bos taurus)
mature NGF homodimer:p75NTR [plasma membrane] (Bos taurus)
mature beta-NGF homodimer [extracellular region] (Bos taurus)
mature beta-NGF homodimer [extracellular region] (Bos taurus)
p75NTR regulates axonogenesis (Bos taurus)
Axonal growth stimulation (Bos taurus)
NGF binding to p75NTR inactivates RHOA (Bos taurus)
RHOA:GDP:ARHGDIA:NGFR:NGF [plasma membrane] (Bos taurus)
mature beta-NGF homodimer [extracellular region] (Bos taurus)
mature beta-NGF homodimer [extracellular region] (Bos taurus)
p75NTR signals via NF-kB (Bos taurus)
NF-kB is activated and signals survival (Bos taurus)
IKKbeta is activated (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Bos taurus)
mature NGF homodimer:p75NTR [plasma membrane] (Bos taurus)
mature beta-NGF homodimer [extracellular region] (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Bos taurus)
mature NGF homodimer:p75NTR [plasma membrane] (Bos taurus)
mature beta-NGF homodimer [extracellular region] (Bos taurus)
IKKbeta phosphorylates IkB causing NF-kB to dissociate (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Bos taurus)
mature NGF homodimer:p75NTR [plasma membrane] (Bos taurus)
mature beta-NGF homodimer [extracellular region] (Bos taurus)
p75NTR recruits signalling complexes (Bos taurus)
IKK-beta is recruited (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Bos taurus)
mature NGF homodimer:p75NTR [plasma membrane] (Bos taurus)
mature beta-NGF homodimer [extracellular region] (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Bos taurus)
mature NGF homodimer:p75NTR [plasma membrane] (Bos taurus)
mature beta-NGF homodimer [extracellular region] (Bos taurus)
IRAK interacts with TRAF6 (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Bos taurus)
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Bos taurus)
mature NGF homodimer:p75NTR [plasma membrane] (Bos taurus)
mature beta-NGF homodimer [extracellular region] (Bos taurus)
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Bos taurus)
mature NGF homodimer:p75NTR [plasma membrane] (Bos taurus)
mature beta-NGF homodimer [extracellular region] (Bos taurus)
MYD88 dissociates (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Bos taurus)
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Bos taurus)
mature NGF homodimer:p75NTR [plasma membrane] (Bos taurus)
mature beta-NGF homodimer [extracellular region] (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Bos taurus)
mature NGF homodimer:p75NTR [plasma membrane] (Bos taurus)
mature beta-NGF homodimer [extracellular region] (Bos taurus)
TRAF6 is auto-ubiquitinated (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Bos taurus)
mature NGF homodimer:p75NTR [plasma membrane] (Bos taurus)
mature beta-NGF homodimer [extracellular region] (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:polyubiquitinated TRAF6:p62 [plasma membrane] (Bos taurus)
mature NGF homodimer:p75NTR [plasma membrane] (Bos taurus)
mature beta-NGF homodimer [extracellular region] (Bos taurus)
p62 is recruited and forms a complex with TRAF6 (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Bos taurus)
mature NGF homodimer:p75NTR [plasma membrane] (Bos taurus)
mature beta-NGF homodimer [extracellular region] (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Bos taurus)
mature NGF homodimer:p75NTR [plasma membrane] (Bos taurus)
mature beta-NGF homodimer [extracellular region] (Bos taurus)
p62 recruits an atypical PKC (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Bos taurus)
mature NGF homodimer:p75NTR [plasma membrane] (Bos taurus)
mature beta-NGF homodimer [extracellular region] (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:aPKCi [plasma membrane] (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Bos taurus)
mature NGF homodimer:p75NTR [plasma membrane] (Bos taurus)
mature beta-NGF homodimer [extracellular region] (Bos taurus)
p75NTR interacts with RIP2 (Bos taurus)
NGF:p75NTR:RIP2 [plasma membrane] (Bos taurus)
mature NGF homodimer:p75NTR [plasma membrane] (Bos taurus)
mature beta-NGF homodimer [extracellular region] (Bos taurus)
mature NGF homodimer:p75NTR [plasma membrane] (Bos taurus)
mature beta-NGF homodimer [extracellular region] (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by NTRKs (Bos taurus)
Expression and Processing of Neurotrophins (Bos taurus)
NGF processing (Bos taurus)
Pro-beta-NGF and mature beta-NGF are secreted (Bos taurus)
mature beta-NGF homodimer [extracellular region] (Bos taurus)
Signaling by NTRK1 (TRKA) (Bos taurus)
Activation of TRKA receptors (Bos taurus)
TRKA activation by NGF (Bos taurus)
Activated TrkA receptor internalizes to endosomes (Bos taurus)
Activated TrkA receptor complex [plasma membrane] (Bos taurus)
mature beta-NGF homodimer [extracellular region] (Bos taurus)
The bound receptor dimerizes (Bos taurus)
beta-NGF dimer:TrkA receptor [plasma membrane] (Bos taurus)
mature beta-NGF homodimer [extracellular region] (Bos taurus)
beta-NGF dimer:TrkA receptor dimer [plasma membrane] (Bos taurus)
beta-NGF dimer:TrkA receptor [plasma membrane] (Bos taurus)
mature beta-NGF homodimer [extracellular region] (Bos taurus)
beta-NGF dimer binds to TrkA receptor (Bos taurus)
beta-NGF dimer:TrkA receptor [plasma membrane] (Bos taurus)
mature beta-NGF homodimer [extracellular region] (Bos taurus)
mature beta-NGF homodimer [extracellular region] (Bos taurus)
PI3K/AKT activation (Bos taurus)
Active IRS recruits PI3K to the plasma membrane and activates it (Bos taurus)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Bos taurus)
mature beta-NGF homodimer [extracellular region] (Bos taurus)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Bos taurus)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Bos taurus)
mature beta-NGF homodimer [extracellular region] (Bos taurus)
Retrograde neurotrophin signalling (Bos taurus)
Axonal transport of NGF:Trk complexes (Bos taurus)
Activated TrkA receptor complex:Clathrin-coated vesicle:Endophilin [plasma membrane] (Bos taurus)
Activated TrkA receptor complex [plasma membrane] (Bos taurus)
mature beta-NGF homodimer [extracellular region] (Bos taurus)
Signalling to ERKs (Bos taurus)
Prolonged ERK activation events (Bos taurus)
ARMS-mediated activation (Bos taurus)
ARMS is phosphorylated by active TrkA receptor (Bos taurus)
Active TrkA receptor:ARMS:Crk complex [plasma membrane] (Bos taurus)
Activated TrkA receptor complex [plasma membrane] (Bos taurus)
mature beta-NGF homodimer [extracellular region] (Bos taurus)
Active TrkA receptor:Phospho-ARMS:Crk complex [plasma membrane] (Bos taurus)
Activated TrkA receptor complex [plasma membrane] (Bos taurus)
mature beta-NGF homodimer [extracellular region] (Bos taurus)
C3G stimulates nucleotide exchange on Rap1 (Bos taurus)
Active TrkA receptor:Phospho-ARMS:Crk complex [plasma membrane] (Bos taurus)
Activated TrkA receptor complex [plasma membrane] (Bos taurus)
mature beta-NGF homodimer [extracellular region] (Bos taurus)
Crk's SH3 domain engages C3G (Bos taurus)
Active TrkA receptor:Phospho-ARMS:Crk complex [plasma membrane] (Bos taurus)
Activated TrkA receptor complex [plasma membrane] (Bos taurus)
mature beta-NGF homodimer [extracellular region] (Bos taurus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
x 2
NGF [extracellular region]
(Bos taurus)
Participates
as an input of
NGF binding to p75NTR inactivates RHOA (Bos taurus)
NGF homodimer binds to p75NTR (Bos taurus)
beta-NGF dimer binds to TrkA receptor (Bos taurus)
as a component of
RHOA:GDP:ARHGDIA:NGFR:NGF [plasma membrane] (Bos taurus)
mature NGF homodimer:p75NTR [plasma membrane] (Bos taurus)
beta-NGF dimer:TrkA receptor [plasma membrane] (Bos taurus)
Activated TrkA receptor complex [plasma membrane] (Bos taurus)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Bos taurus)
as an output of
Pro-beta-NGF and mature beta-NGF are secreted (Bos taurus)
Inferred From
mature beta-NGF homodimer [extracellular region]
(Homo sapiens)
beta-NGF homodimer [extracellular region]
(Homo sapiens)
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