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CUL5 [cytosol]
Stable Identifier
R-BTA-180528
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
CUL5, A0A3Q1MXH0
Locations in the PathwayBrowser
Expand all
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Class I MHC mediated antigen processing & presentation (Bos taurus)
Antigen processing: Ubiquitination & Proteasome degradation (Bos taurus)
Interaction of E3 with substrate and E2-Ub complex (Bos taurus)
Ag-substrate:E3:E2:Ub [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Bos taurus)
Cul5-SCF complex [cytosol] (Bos taurus)
CUL5 [cytosol] (Bos taurus)
RBX1:CUL5:EloB/C:LRRC41 [cytosol] (Bos taurus)
Cul5-SCF complex [cytosol] (Bos taurus)
CUL5 [cytosol] (Bos taurus)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Bos taurus)
CUL5 [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Bos taurus)
Cul5-SCF complex [cytosol] (Bos taurus)
CUL5 [cytosol] (Bos taurus)
RBX1:CUL5:EloB/C:LRRC41 [cytosol] (Bos taurus)
Cul5-SCF complex [cytosol] (Bos taurus)
CUL5 [cytosol] (Bos taurus)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Bos taurus)
CUL5 [cytosol] (Bos taurus)
Polyubiquitination of substrate (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Bos taurus)
Cul5-SCF complex [cytosol] (Bos taurus)
CUL5 [cytosol] (Bos taurus)
RBX1:CUL5:EloB/C:LRRC41 [cytosol] (Bos taurus)
Cul5-SCF complex [cytosol] (Bos taurus)
CUL5 [cytosol] (Bos taurus)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Bos taurus)
CUL5 [cytosol] (Bos taurus)
E3:K48-polyubiquitinated substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Bos taurus)
Cul5-SCF complex [cytosol] (Bos taurus)
CUL5 [cytosol] (Bos taurus)
RBX1:CUL5:EloB/C:LRRC41 [cytosol] (Bos taurus)
Cul5-SCF complex [cytosol] (Bos taurus)
CUL5 [cytosol] (Bos taurus)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Bos taurus)
CUL5 [cytosol] (Bos taurus)
E3:Ub:substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Bos taurus)
Cul5-SCF complex [cytosol] (Bos taurus)
CUL5 [cytosol] (Bos taurus)
RBX1:CUL5:EloB/C:LRRC41 [cytosol] (Bos taurus)
Cul5-SCF complex [cytosol] (Bos taurus)
CUL5 [cytosol] (Bos taurus)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Bos taurus)
CUL5 [cytosol] (Bos taurus)
Release of E3 from polyubiquitinated substrate (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Bos taurus)
Cul5-SCF complex [cytosol] (Bos taurus)
CUL5 [cytosol] (Bos taurus)
RBX1:CUL5:EloB/C:LRRC41 [cytosol] (Bos taurus)
Cul5-SCF complex [cytosol] (Bos taurus)
CUL5 [cytosol] (Bos taurus)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Bos taurus)
CUL5 [cytosol] (Bos taurus)
E3:K48-polyubiquitinated substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Bos taurus)
Cul5-SCF complex [cytosol] (Bos taurus)
CUL5 [cytosol] (Bos taurus)
RBX1:CUL5:EloB/C:LRRC41 [cytosol] (Bos taurus)
Cul5-SCF complex [cytosol] (Bos taurus)
CUL5 [cytosol] (Bos taurus)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Bos taurus)
CUL5 [cytosol] (Bos taurus)
Transfer of Ub from E2 to substrate and release of E2 (Bos taurus)
Ag-substrate:E3:E2:Ub [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Bos taurus)
Cul5-SCF complex [cytosol] (Bos taurus)
CUL5 [cytosol] (Bos taurus)
RBX1:CUL5:EloB/C:LRRC41 [cytosol] (Bos taurus)
Cul5-SCF complex [cytosol] (Bos taurus)
CUL5 [cytosol] (Bos taurus)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Bos taurus)
CUL5 [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Bos taurus)
Cul5-SCF complex [cytosol] (Bos taurus)
CUL5 [cytosol] (Bos taurus)
RBX1:CUL5:EloB/C:LRRC41 [cytosol] (Bos taurus)
Cul5-SCF complex [cytosol] (Bos taurus)
CUL5 [cytosol] (Bos taurus)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Bos taurus)
CUL5 [cytosol] (Bos taurus)
E3:Ub:substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Bos taurus)
Cul5-SCF complex [cytosol] (Bos taurus)
CUL5 [cytosol] (Bos taurus)
RBX1:CUL5:EloB/C:LRRC41 [cytosol] (Bos taurus)
Cul5-SCF complex [cytosol] (Bos taurus)
CUL5 [cytosol] (Bos taurus)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Bos taurus)
CUL5 [cytosol] (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
Signaling by CSF3 (G-CSF) (Bos taurus)
Inactivation of CSF3 (G-CSF) signaling (Bos taurus)
SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Bos taurus)
CUL5 [cytosol] (Bos taurus)
SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 [endocytic vesicle membrane] (Bos taurus)
CUL5 [cytosol] (Bos taurus)
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
Neddylation (Bos taurus)
AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Bos taurus)
NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
CRL5 E3 ubiquitin ligase [cytosol] (Bos taurus)
CUL5 [cytosol] (Bos taurus)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Bos taurus)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Bos taurus)
CRL E3 ubiquitin ligases [cytosol] (Bos taurus)
CRL5 E3 ubiquitin ligase [cytosol] (Bos taurus)
CUL5 [cytosol] (Bos taurus)
CRL E3 ubiquitin ligases [cytosol] (Bos taurus)
CRL5 E3 ubiquitin ligase [cytosol] (Bos taurus)
CUL5 [cytosol] (Bos taurus)
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Bos taurus)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Bos taurus)
CRL E3 ubiquitin ligases [cytosol] (Bos taurus)
CRL5 E3 ubiquitin ligase [cytosol] (Bos taurus)
CUL5 [cytosol] (Bos taurus)
CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
CRL5 E3 ubiquitin ligase [cytosol] (Bos taurus)
CUL5 [cytosol] (Bos taurus)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Bos taurus)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
CRL5 E3 ubiquitin ligase [cytosol] (Bos taurus)
CUL5 [cytosol] (Bos taurus)
NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Bos taurus)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
CRL5 E3 ubiquitin ligase [cytosol] (Bos taurus)
CUL5 [cytosol] (Bos taurus)
NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
CRL5 E3 ubiquitin ligase [cytosol] (Bos taurus)
CUL5 [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by ERBB2 (Bos taurus)
Downregulation of ERBB2 signaling (Bos taurus)
CUL5 mediates ubiquitination of ERBB2 (Bos taurus)
CUL5 [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:A0A3Q1MXH0
Gene Names
CUL5
Reference Genes
ENSEMBL:ENSBTAG00000012882.7
ENSEMBL:ENSBTAG00000012882.8 CUL5
Other Identifiers
510331
GO:0005694
GO:0006511
GO:0016567
GO:0019005
GO:0030163
GO:0030674
GO:0031146
GO:0031461
GO:0031466
GO:0031625
GO:0036211
GO:0043226
GO:0060090
GO:0090734
Participates
as an output of
SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Bos taurus)
as a component of
SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 [endocytic vesicle membrane] (Bos taurus)
CRL5 E3 ubiquitin ligase [cytosol] (Bos taurus)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Bos taurus)
Cul5-SCF complex [cytosol] (Bos taurus)
Other forms of this molecule
CUL5 [cytosol]
Inferred From
CUL5 [cytosol]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000166266
Ensembl
ENSBTAG00000012882
,
ENSBTAT00000068692
,
ENSBTAP00000060422
VGNC
27834
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