Reactome | HUS1 [nucleoplasm]

HUS1 [nucleoplasm]

Stable Identifier

R-BTA-176374

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

nucleoplasm

Synonyms

HUS1, E1BG06

Locations in the PathwayBrowser

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Cell Cycle (Bos taurus)

- Cell Cycle Checkpoints (Bos taurus)
  - G2/M Checkpoints (Bos taurus)
    - Activation of ATR in response to replication stress (Bos taurus)
      - Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Bos taurus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Bos taurus)
        
        HUS1 [nucleoplasm] (Bos taurus)
        
        Rad9-Hus1-Rad1 bound to DNA [nucleoplasm] (Bos taurus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Bos taurus)
        
        HUS1 [nucleoplasm] (Bos taurus)
    - G2/M DNA damage checkpoint (Bos taurus)
      - ATR phosphorylates TP53 (Bos taurus)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Bos taurus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Bos taurus)
        
        HUS1 [nucleoplasm] (Bos taurus)

DNA Repair (Bos taurus)

- DNA Double-Strand Break Repair (Bos taurus)
  - Homology Directed Repair (Bos taurus)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Bos taurus)
      - HDR through Single Strand Annealing (SSA) (Bos taurus)
        
        Association of RAD51 with RAD52:DNA double-strand break ends (Bos taurus)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Bos taurus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Bos taurus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Bos taurus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Bos taurus)
        
        HUS1 [nucleoplasm] (Bos taurus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Bos taurus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Bos taurus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Bos taurus)
        
        HUS1 [nucleoplasm] (Bos taurus)
        
        Association of RAD52 with the RPA complex at resected DNA DSBs (Bos taurus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Bos taurus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Bos taurus)
        
        HUS1 [nucleoplasm] (Bos taurus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Bos taurus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Bos taurus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Bos taurus)
        
        HUS1 [nucleoplasm] (Bos taurus)
        
        ERCC1:XPF cleaves flaps generated by SSA (Bos taurus)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Bos taurus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Bos taurus)
        
        ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Bos taurus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Bos taurus)
        
        HUS1 [nucleoplasm] (Bos taurus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Bos taurus)
        
        HUS1 [nucleoplasm] (Bos taurus)
        
        RAD52 promotes single strand annealing at resected DNA DSBs (Bos taurus)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Bos taurus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Bos taurus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Bos taurus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Bos taurus)
        
        HUS1 [nucleoplasm] (Bos taurus)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Bos taurus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Bos taurus)
        
        ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Bos taurus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Bos taurus)
        
        HUS1 [nucleoplasm] (Bos taurus)
      - Processing of DNA double-strand break ends (Bos taurus)
        
        ATR activation at DNA DSBs (Bos taurus)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Bos taurus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Bos taurus)
        
        HUS1 [nucleoplasm] (Bos taurus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Bos taurus)
        
        HUS1 [nucleoplasm] (Bos taurus)
        
        ATR phosphorylates RPA2 (Bos taurus)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Bos taurus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Bos taurus)
        
        HUS1 [nucleoplasm] (Bos taurus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Bos taurus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Bos taurus)
        
        HUS1 [nucleoplasm] (Bos taurus)

Gene expression (Transcription) (Bos taurus)

- RNA Polymerase II Transcription (Bos taurus)
  - Generic Transcription Pathway (Bos taurus)
    - Transcriptional Regulation by TP53 (Bos taurus)
      - Regulation of TP53 Activity (Bos taurus)
        
        Regulation of TP53 Activity through Phosphorylation (Bos taurus)
        
        ATR phosphorylates TP53 (Bos taurus)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Bos taurus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Bos taurus)
        
        HUS1 [nucleoplasm] (Bos taurus)

External Reference Information

External Reference

UniProt:E1BG06

Gene Names

HUS1

Reference Genes

BioGPS Gene:514142 HUS1

ENSEMBL:ENSBTAG00000013226.5

Monarch:514142 HUS1

NCBI Gene:514142 HUS1

UCSC:E1BG06 HUS1

Reference Transcript

RefSeq:XM_005205589.3 HUS1

Other Identifiers

514142

GO:0000077

GO:0005634

GO:0030896

GO:0043226

GO:0071479

Participates

as a component of

RAD9:HUS1:RAD1 [nucleoplasm] (Bos taurus)

Inferred From

HUS1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_005205646.1

ENSEMBL

ENSBTAT00000017599, ENSBTAP00000017599

VGNC

30008

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