Reactome | RAD9B [nucleoplasm]

RAD9B

Stable Identifier

R-BTA-176325

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

nucleoplasm

Synonyms

F1MFW1

Locations in the PathwayBrowser

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Cell Cycle (Bos taurus)

- Cell Cycle Checkpoints (Bos taurus)
  - G2/M Checkpoints (Bos taurus)
    - Activation of ATR in response to replication stress (Bos taurus)
      - Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Bos taurus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Bos taurus)
        
        RAD9 [nucleoplasm] (Bos taurus)
        
        RAD9B [nucleoplasm] (Bos taurus)
        
        Rad9-Hus1-Rad1 bound to DNA [nucleoplasm] (Bos taurus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Bos taurus)
        
        RAD9 [nucleoplasm] (Bos taurus)
        
        RAD9B [nucleoplasm] (Bos taurus)
    - G2/M DNA damage checkpoint (Bos taurus)
      - ATR phosphorylates TP53 (Bos taurus)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Bos taurus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Bos taurus)
        
        RAD9 [nucleoplasm] (Bos taurus)
        
        RAD9B [nucleoplasm] (Bos taurus)

DNA Repair (Bos taurus)

- DNA Double-Strand Break Repair (Bos taurus)
  - Homology Directed Repair (Bos taurus)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Bos taurus)
      - HDR through Homologous Recombination (HRR) (Bos taurus)
        
        Homologous DNA Pairing and Strand Exchange (Bos taurus)
        
        Presynaptic phase of homologous DNA pairing and strand exchange (Bos taurus)
        
        RAD51 binds BRCA2 at resected DNA DSBs (Bos taurus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Bos taurus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Bos taurus)
        
        RAD9 [nucleoplasm] (Bos taurus)
        
        RAD9B [nucleoplasm] (Bos taurus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Bos taurus)
        
        RAD9 [nucleoplasm] (Bos taurus)
        
        RAD9B [nucleoplasm] (Bos taurus)
      - HDR through Single Strand Annealing (SSA) (Bos taurus)
        
        Association of RAD51 with RAD52:DNA double-strand break ends (Bos taurus)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Bos taurus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Bos taurus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Bos taurus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Bos taurus)
        
        RAD9 [nucleoplasm] (Bos taurus)
        
        RAD9B [nucleoplasm] (Bos taurus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Bos taurus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Bos taurus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Bos taurus)
        
        RAD9 [nucleoplasm] (Bos taurus)
        
        RAD9B [nucleoplasm] (Bos taurus)
        
        Association of RAD52 with the RPA complex at resected DNA DSBs (Bos taurus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Bos taurus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Bos taurus)
        
        RAD9 [nucleoplasm] (Bos taurus)
        
        RAD9B [nucleoplasm] (Bos taurus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Bos taurus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Bos taurus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Bos taurus)
        
        RAD9 [nucleoplasm] (Bos taurus)
        
        RAD9B [nucleoplasm] (Bos taurus)
        
        ERCC1:XPF cleaves flaps generated by SSA (Bos taurus)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Bos taurus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Bos taurus)
        
        ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Bos taurus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Bos taurus)
        
        RAD9 [nucleoplasm] (Bos taurus)
        
        RAD9B [nucleoplasm] (Bos taurus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Bos taurus)
        
        RAD9 [nucleoplasm] (Bos taurus)
        
        RAD9B [nucleoplasm] (Bos taurus)
        
        RAD52 promotes single strand annealing at resected DNA DSBs (Bos taurus)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Bos taurus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Bos taurus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Bos taurus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Bos taurus)
        
        RAD9 [nucleoplasm] (Bos taurus)
        
        RAD9B [nucleoplasm] (Bos taurus)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Bos taurus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Bos taurus)
        
        ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Bos taurus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Bos taurus)
        
        RAD9 [nucleoplasm] (Bos taurus)
        
        RAD9B [nucleoplasm] (Bos taurus)
      - Processing of DNA double-strand break ends (Bos taurus)
        
        ATR activation at DNA DSBs (Bos taurus)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Bos taurus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Bos taurus)
        
        RAD9 [nucleoplasm] (Bos taurus)
        
        RAD9B [nucleoplasm] (Bos taurus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Bos taurus)
        
        RAD9 [nucleoplasm] (Bos taurus)
        
        RAD9B [nucleoplasm] (Bos taurus)
        
        ATR phosphorylates RPA2 (Bos taurus)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Bos taurus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Bos taurus)
        
        RAD9 [nucleoplasm] (Bos taurus)
        
        RAD9B [nucleoplasm] (Bos taurus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Bos taurus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Bos taurus)
        
        RAD9 [nucleoplasm] (Bos taurus)
        
        RAD9B [nucleoplasm] (Bos taurus)
        
        Activation of CHEK1 at resected DNA DSBs (Bos taurus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Bos taurus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Bos taurus)
        
        RAD9 [nucleoplasm] (Bos taurus)
        
        RAD9B [nucleoplasm] (Bos taurus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Bos taurus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Bos taurus)
        
        RAD9 [nucleoplasm] (Bos taurus)
        
        RAD9B [nucleoplasm] (Bos taurus)
        
        CHEK1 is recruited to resected DNA DSBs (Bos taurus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Bos taurus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Bos taurus)
        
        RAD9 [nucleoplasm] (Bos taurus)
        
        RAD9B [nucleoplasm] (Bos taurus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Bos taurus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Bos taurus)
        
        RAD9 [nucleoplasm] (Bos taurus)
        
        RAD9B [nucleoplasm] (Bos taurus)

Gene expression (Transcription) (Bos taurus)

- RNA Polymerase II Transcription (Bos taurus)
  - Generic Transcription Pathway (Bos taurus)
    - Transcriptional Regulation by TP53 (Bos taurus)
      - Regulation of TP53 Activity (Bos taurus)
        
        Regulation of TP53 Activity through Phosphorylation (Bos taurus)
        
        ATR phosphorylates TP53 (Bos taurus)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Bos taurus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Bos taurus)
        
        RAD9 [nucleoplasm] (Bos taurus)
        
        RAD9B [nucleoplasm] (Bos taurus)

External Reference Information

External Reference

UniProt:F1MFW1

Reference Genes

BioGPS Gene:616597

dbSNP Gene:616597

ENSEMBL:ENSBTAG00000018330

Monarch:616597

NCBI Gene:616597

Reference Transcript

RefSeq:XM_010813978.2

Other Identifiers

616597

Bt.25691

Bt.25691.1.A1_at

DAAA02045280

DAAA02045281

ENSBTAG00000018330

ENSBTAP00000024392

ENSBTAT00000024392

EntrezGene:616597

GO:0000075

GO:0000077

GO:0000228

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005694

GO:0006259

GO:0006281

GO:0006950

GO:0007049

GO:0008150

GO:0030896

GO:0034641

GO:0043226

GO:0043234

IPR007268

IPR026584

NM_001035479

NP_001030556

PF04139

RAD9B

UPI000179DABD

XM_005217926

XM_005217927

XM_010813978

XP_005217983

XP_010812280

Participant Of

hasMember

RAD9 [nucleoplasm]

Inferred From

RAD9B [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_010812280.1