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SMURF2 [cytosol]
Stable Identifier
R-BTA-173537
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
SMURF2, A0A3Q1LJ39
Locations in the PathwayBrowser
Expand all
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Class I MHC mediated antigen processing & presentation (Bos taurus)
Antigen processing: Ubiquitination & Proteasome degradation (Bos taurus)
Interaction of E3 with substrate and E2-Ub complex (Bos taurus)
Ag-substrate:E3:E2:Ub [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
SMURF2 [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
SMURF2 [cytosol] (Bos taurus)
Polyubiquitination of substrate (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
SMURF2 [cytosol] (Bos taurus)
E3:K48-polyubiquitinated substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
SMURF2 [cytosol] (Bos taurus)
E3:Ub:substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
SMURF2 [cytosol] (Bos taurus)
Release of E3 from polyubiquitinated substrate (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
SMURF2 [cytosol] (Bos taurus)
E3:K48-polyubiquitinated substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
SMURF2 [cytosol] (Bos taurus)
Transfer of Ub from E2 to substrate and release of E2 (Bos taurus)
Ag-substrate:E3:E2:Ub [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
SMURF2 [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
SMURF2 [cytosol] (Bos taurus)
E3:Ub:substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
SMURF2 [cytosol] (Bos taurus)
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
Deubiquitination (Bos taurus)
Ub-specific processing proteases (Bos taurus)
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Bos taurus)
USP15:SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1 [cytosol] (Bos taurus)
SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1 [cytosol] (Bos taurus)
SMAD7:SMURF2:TGFBR1 [plasma membrane] (Bos taurus)
SMAD7:SMURF2 [cytosol] (Bos taurus)
SMURF2 [cytosol] (Bos taurus)
USP15:Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,,Ub-KEAP1,SMAD7:SMURF2:Ub-TGFBR1 [cytosol] (Bos taurus)
Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,,Ub-KEAP1,SMAD7:SMURF2:Ub-TGFBR1 [cytosol] (Bos taurus)
SMAD7:SMURF2:Ub-TGFBR1 [plasma membrane] (Bos taurus)
SMURF2 [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Signaling by Hedgehog (Bos taurus)
Hedgehog 'on' state (Bos taurus)
SMURF1/2 dissociates from ub-PTCH1 (Bos taurus)
SMURF [cytosol] (Bos taurus)
SMURF2 [cytosol] (Bos taurus)
ub-PTCH1:SMURF [ciliary membrane] (Bos taurus)
SMURF [cytosol] (Bos taurus)
SMURF2 [cytosol] (Bos taurus)
Signaling by TGFB family members (Bos taurus)
Signaling by BMP (Bos taurus)
I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Bos taurus)
BMP:p-BMPR:I-SMAD:SMURF [plasma membrane] (Bos taurus)
I-SMAD:SMURF [cytosol] (Bos taurus)
SMURF [cytosol] (Bos taurus)
SMURF2 [cytosol] (Bos taurus)
I-SMAD:SMURF [cytosol] (Bos taurus)
SMURF [cytosol] (Bos taurus)
SMURF2 [cytosol] (Bos taurus)
Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Bos taurus)
SMURF [cytosol] (Bos taurus)
SMURF2 [cytosol] (Bos taurus)
Signaling by TGF-beta Receptor Complex (Bos taurus)
TGF-beta receptor signaling activates SMADs (Bos taurus)
Downregulation of TGF-beta receptor signaling (Bos taurus)
SMURF2 binds SMAD2 (Bos taurus)
SMAD2:SMURF2 [cytosol] (Bos taurus)
SMURF2 [cytosol] (Bos taurus)
SMURF2 [cytosol] (Bos taurus)
SMURF2 ubiquitinates SMAD2 (Bos taurus)
SMAD2:SMURF2 [cytosol] (Bos taurus)
SMURF2 [cytosol] (Bos taurus)
SMURF2 [cytosol] (Bos taurus)
Signaling by WNT (Bos taurus)
Beta-catenin independent WNT signaling (Bos taurus)
PCP/CE pathway (Bos taurus)
Asymmetric localization of PCP proteins (Bos taurus)
SMURF1/2 are recruited to the DVL2:PARD6A complex (Bos taurus)
PARD6A:pp-DVL2:SMURF [plasma membrane] (Bos taurus)
SMURF [cytosol] (Bos taurus)
SMURF2 [cytosol] (Bos taurus)
SMURF [cytosol] (Bos taurus)
SMURF2 [cytosol] (Bos taurus)
SMURF1/2 ubiquitinates PRICKLE1 (Bos taurus)
PARD6A:pp-DVL2:SMURF [plasma membrane] (Bos taurus)
SMURF [cytosol] (Bos taurus)
SMURF2 [cytosol] (Bos taurus)
SMURF [cytosol] (Bos taurus)
SMURF2 [cytosol] (Bos taurus)
TCF dependent signaling in response to WNT (Bos taurus)
Degradation of AXIN (Bos taurus)
AXIN is ubiquitinated by SMURF2 (Bos taurus)
AXIN:SMURF2 [cytosol] (Bos taurus)
SMURF2 [cytosol] (Bos taurus)
SMURF2 [cytosol] (Bos taurus)
ub-AXIN:SMURF2 [cytosol] (Bos taurus)
SMURF2 [cytosol] (Bos taurus)
SMURF2 binds AXIN (Bos taurus)
AXIN:SMURF2 [cytosol] (Bos taurus)
SMURF2 [cytosol] (Bos taurus)
SMURF2 [cytosol] (Bos taurus)
Ubiquitinated AXIN is degraded by the proteasome (Bos taurus)
SMURF2 [cytosol] (Bos taurus)
ub-AXIN:SMURF2 [cytosol] (Bos taurus)
SMURF2 [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:A0A3Q1LJ39
Gene Names
SMURF2
Reference Genes
ENSEMBL:ENSBTAG00000019853.6
UCSC:A0A3Q1LJ39 SMURF2
Other Identifiers
GO:0000151
GO:0003824
GO:0004842
GO:0006511
GO:0016607
GO:0016740
GO:0030512
GO:0042802
GO:0046332
GO:0061630
GO:0140096
GO:1901165
Participates
as a component of
SMAD7:SMURF2:Ub-TGFBR1 [plasma membrane] (Bos taurus)
ub-AXIN:SMURF2 [cytosol] (Bos taurus)
AXIN:SMURF2 [cytosol] (Bos taurus)
SMAD7:SMURF2 [cytosol] (Bos taurus)
SMAD2:SMURF2 [cytosol] (Bos taurus)
as an output of
Ubiquitinated AXIN is degraded by the proteasome (Bos taurus)
SMURF2 ubiquitinates SMAD2 (Bos taurus)
as an input of
SMURF2 binds AXIN (Bos taurus)
SMURF2 binds SMAD2 (Bos taurus)
as a member of
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
SMURF [cytosol] (Bos taurus)
Other forms of this molecule
SMURF2 [nucleoplasm]
Inferred From
SMURF2 [cytosol]
(Homo sapiens)
Cross References
ENSEMBL
ENSBTAP00000059296
,
ENSBTAT00000071414
VGNC
35041
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