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phospho-MAP2K2 [cytosol]
Stable Identifier
R-BTA-169292
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
p-S222,S226-MAP2K2, A0A3S5ZPX3
Locations in the PathwayBrowser
Expand all
Signal Transduction (Bos taurus)
MAPK family signaling cascades (Bos taurus)
MAPK1/MAPK3 signaling (Bos taurus)
RAF/MAP kinase cascade (Bos taurus)
MAP2K and MAPK activation (Bos taurus)
Dual mechanism MAPK inhibitors bind MAPKs (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Bos taurus)
phospho-MAP2K2 [cytosol] (Bos taurus)
p-S222,S226 MAP2K2 dimer [cytosol] (Bos taurus)
phospho-MAP2K2 [cytosol] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Bos taurus)
phospho-MAP2K2 [cytosol] (Bos taurus)
p-S222,S226 MAP2K2 dimer [cytosol] (Bos taurus)
phospho-MAP2K2 [cytosol] (Bos taurus)
MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Bos taurus)
WDR83:LAMTOR2:LAMTOR3:activated RAF:p-2S MAP2K:p-T,Y MAPK complex [endosome membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Bos taurus)
phospho-MAP2K2 [cytosol] (Bos taurus)
p-S222,S226 MAP2K2 dimer [cytosol] (Bos taurus)
phospho-MAP2K2 [cytosol] (Bos taurus)
MAP2Ks phosphorylate MAPK at the Golgi membrane (Bos taurus)
IL17RD:p-2S MAP2Ks:MAPKs [Golgi membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Bos taurus)
phospho-MAP2K2 [cytosol] (Bos taurus)
p-S222,S226 MAP2K2 dimer [cytosol] (Bos taurus)
phospho-MAP2K2 [cytosol] (Bos taurus)
IL17RD:p-2S MAP2Ks:p-T,Y MAPKs [Golgi membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Bos taurus)
phospho-MAP2K2 [cytosol] (Bos taurus)
p-S222,S226 MAP2K2 dimer [cytosol] (Bos taurus)
phospho-MAP2K2 [cytosol] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Bos taurus)
phospho-MAP2K2 [cytosol] (Bos taurus)
p-S222,S226 MAP2K2 dimer [cytosol] (Bos taurus)
phospho-MAP2K2 [cytosol] (Bos taurus)
MAP2Ks phosphorylate MAPKs (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Bos taurus)
phospho-MAP2K2 [cytosol] (Bos taurus)
p-S222,S226 MAP2K2 dimer [cytosol] (Bos taurus)
phospho-MAP2K2 [cytosol] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Bos taurus)
phospho-MAP2K2 [cytosol] (Bos taurus)
p-S222,S226 MAP2K2 dimer [cytosol] (Bos taurus)
phospho-MAP2K2 [cytosol] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Bos taurus)
phospho-MAP2K2 [cytosol] (Bos taurus)
p-S222,S226 MAP2K2 dimer [cytosol] (Bos taurus)
phospho-MAP2K2 [cytosol] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Bos taurus)
phospho-MAP2K2 [cytosol] (Bos taurus)
p-S222,S226 MAP2K2 dimer [cytosol] (Bos taurus)
phospho-MAP2K2 [cytosol] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Bos taurus)
phospho-MAP2K2 [cytosol] (Bos taurus)
p-S222,S226 MAP2K2 dimer [cytosol] (Bos taurus)
phospho-MAP2K2 [cytosol] (Bos taurus)
RAF phosphorylates MAP2K dimer (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Bos taurus)
phospho-MAP2K2 [cytosol] (Bos taurus)
p-S222,S226 MAP2K2 dimer [cytosol] (Bos taurus)
phospho-MAP2K2 [cytosol] (Bos taurus)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Bos taurus)
phospho-MAP2K2 [cytosol] (Bos taurus)
p-S222,S226 MAP2K2 dimer [cytosol] (Bos taurus)
phospho-MAP2K2 [cytosol] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Bos taurus)
phospho-MAP2K2 [cytosol] (Bos taurus)
p-S222,S226 MAP2K2 dimer [cytosol] (Bos taurus)
phospho-MAP2K2 [cytosol] (Bos taurus)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Bos taurus)
phospho-MAP2K2 [cytosol] (Bos taurus)
p-S222,S226 MAP2K2 dimer [cytosol] (Bos taurus)
phospho-MAP2K2 [cytosol] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Bos taurus)
phospho-MAP2K2 [cytosol] (Bos taurus)
p-S222,S226 MAP2K2 dimer [cytosol] (Bos taurus)
phospho-MAP2K2 [cytosol] (Bos taurus)
RAF activation (Bos taurus)
Phosphorylation of RAF (Bos taurus)
RAF activating kinases [plasma membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Bos taurus)
phospho-MAP2K2 [cytosol] (Bos taurus)
p-S222,S226 MAP2K2 dimer [cytosol] (Bos taurus)
phospho-MAP2K2 [cytosol] (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by NTRKs (Bos taurus)
Signaling by NTRK1 (TRKA) (Bos taurus)
Signalling to ERKs (Bos taurus)
Prolonged ERK activation events (Bos taurus)
Frs2-mediated activation (Bos taurus)
Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Bos taurus)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Bos taurus)
phospho-MAP2K2 [cytosol] (Bos taurus)
p-S222,S226 MAP2K2 dimer [cytosol] (Bos taurus)
phospho-MAP2K2 [cytosol] (Bos taurus)
MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Bos taurus)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Bos taurus)
phospho-MAP2K2 [cytosol] (Bos taurus)
p-S222,S226 MAP2K2 dimer [cytosol] (Bos taurus)
phospho-MAP2K2 [cytosol] (Bos taurus)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Bos taurus)
phospho-MAP2K2 [cytosol] (Bos taurus)
p-S222,S226 MAP2K2 dimer [cytosol] (Bos taurus)
phospho-MAP2K2 [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:A0A3S5ZPX3
Gene Names
MAP2K2
Reference Genes
ENSEMBL:ENSBTAG00000024450
Other Identifiers
510434
Bt.23040.1.A1_at
Bt.7039.1.S1_a_at
GO:0000166
GO:0000187
GO:0000902
GO:0002376
GO:0003674
GO:0004672
GO:0004674
GO:0004708
GO:0005524
GO:0005575
GO:0005622
GO:0005737
GO:0006464
GO:0006468
GO:0006950
GO:0007165
GO:0007507
GO:0008150
GO:0008283
GO:0016301
GO:0030154
GO:0030878
GO:0040011
GO:0043167
GO:0048538
GO:0048646
GO:0048679
GO:0048856
GO:0048870
GO:0050772
GO:0060090
GO:0060324
GO:0060425
GO:0060440
GO:0060502
GO:0070371
GO:2000147
Participant Of
hasComponent
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol]
p-2S,T MAP2K1:p-2S MAPK2K2 heterodimer [cytosol]
p-S222,S226 MAP2K2 dimer [cytosol]
Other forms of this molecule
MAP2K2 [cytosol]
phospho-MAP2K2 [cytosol]
Inferred From
p-S222,S226-MAP2K2 [cytosol] (Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 222 (in Homo sapiens)
Coordinate
222
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 226 (in Homo sapiens)
Coordinate
226
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
OpenTargets
ENSG00000126934
Ensembl
ENSBTAG00000024450
,
ENSBTAP00000011377
,
ENSBTAT00000011377
VGNC
55215
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