Reactome | LCK [cytosol]

LCK [cytosol]

Stable Identifier

R-BTA-167609

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

LCK, Q3ZCM0

Locations in the PathwayBrowser

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Signal Transduction (Bos taurus)

- Intracellular signaling by second messengers (Bos taurus)
  - PIP3 activates AKT signaling (Bos taurus)
    - Negative regulation of the PI3K/AKT network (Bos taurus)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Bos taurus)
        
        PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
        
        Activator:PI3K [plasma membrane] (Bos taurus)
        
        CD28:PI3K [plasma membrane] (Bos taurus)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Bos taurus)
        
        FYN,LCK [cytosol] (Bos taurus)
        
        LCK [cytosol] (Bos taurus)
    - PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
      - Activator:PI3K [plasma membrane] (Bos taurus)
        
        CD28:PI3K [plasma membrane] (Bos taurus)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Bos taurus)
        
        FYN,LCK [cytosol] (Bos taurus)
        
        LCK [cytosol] (Bos taurus)
- Signaling by Receptor Tyrosine Kinases (Bos taurus)
  - Signaling by SCF-KIT (Bos taurus)
    - Dimerization of STATs (Bos taurus)
      - p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        LCK [cytosol] (Bos taurus)
      - p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        LCK [cytosol] (Bos taurus)
    - Disassociation and translocation of STATs to the nucleus (Bos taurus)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        LCK [cytosol] (Bos taurus)
      - p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        LCK [cytosol] (Bos taurus)
    - GRB2 is indirectly recruited to p-KIT through SHP2 (Bos taurus)
      - GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        LCK [cytosol] (Bos taurus)
      - p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        LCK [cytosol] (Bos taurus)
    - Indirect recruitment of GAB2 to p-KIT (Bos taurus)
      - GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        LCK [cytosol] (Bos taurus)
      - GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        LCK [cytosol] (Bos taurus)
    - Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Bos taurus)
      - PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        LCK [cytosol] (Bos taurus)
      - p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        LCK [cytosol] (Bos taurus)
    - JAK2 binds to p-KIT (Bos taurus)
      - JAK2:SFKS:p-KIT complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        LCK [cytosol] (Bos taurus)
      - SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        LCK [cytosol] (Bos taurus)
    - Phosphorylation and activation of VAV1 (Bos taurus)
      - SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        LCK [cytosol] (Bos taurus)
      - Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        LCK [cytosol] (Bos taurus)
    - Phosphorylation of GAB2 by SFKs (Bos taurus)
      - GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        LCK [cytosol] (Bos taurus)
      - Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        LCK [cytosol] (Bos taurus)
      - p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        LCK [cytosol] (Bos taurus)
    - Phosphorylation of JAK2 (Bos taurus)
      - JAK2:SFKS:p-KIT complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        LCK [cytosol] (Bos taurus)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        LCK [cytosol] (Bos taurus)
    - Phosphorylation of SHP2 by SFKs (Bos taurus)
      - SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        LCK [cytosol] (Bos taurus)
      - Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        LCK [cytosol] (Bos taurus)
      - p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        LCK [cytosol] (Bos taurus)
    - Phosphorylation of STATs (Bos taurus)
      - p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        LCK [cytosol] (Bos taurus)
      - p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        LCK [cytosol] (Bos taurus)
    - Phosphorylation of p-KIT on Y900 by Src kinases (Bos taurus)
      - SFKs:p-8Y-KIT:sSCF dimer:p-8Y-KIT [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        LCK [cytosol] (Bos taurus)
      - SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        LCK [cytosol] (Bos taurus)
      - Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        LCK [cytosol] (Bos taurus)
    - Recruitment of STATs (Bos taurus)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        LCK [cytosol] (Bos taurus)
      - p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        LCK [cytosol] (Bos taurus)
    - Regulation of KIT signaling (Bos taurus)
      - Interaction of APS and p-KIT (Bos taurus)
        
        APS dimer:p-c-Kit:SFKs complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        LCK [cytosol] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        LCK [cytosol] (Bos taurus)
      - Phosphorylation of APS (Bos taurus)
        
        APS dimer:p-c-Kit:SFKs complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        LCK [cytosol] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        LCK [cytosol] (Bos taurus)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        LCK [cytosol] (Bos taurus)
      - Recruitment of CBL to KIT (Bos taurus)
        
        CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] (Bos taurus)
        
        Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Bos taurus)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        LCK [cytosol] (Bos taurus)
        
        Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Bos taurus)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        LCK [cytosol] (Bos taurus)
    - SHP2 interacts with p-KIT (Bos taurus)
      - SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        LCK [cytosol] (Bos taurus)
      - SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        LCK [cytosol] (Bos taurus)
    - Synthesis of PIP3 from PIP2 by PI3K (Bos taurus)
      - PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        LCK [cytosol] (Bos taurus)
- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Bos taurus)
  - Signaling by Rho GTPases (Bos taurus)
    - RHO GTPase cycle (Bos taurus)
      - RHOH GTPase cycle (Bos taurus)
        
        RHOH binds effectors at the plasma membrane (Bos taurus)
        
        RHOH effectors [cytosol] (Bos taurus)
        
        LCK [cytosol] (Bos taurus)
        
        RHOH:GTP:RHOH effectors [plasma membrane] (Bos taurus)
        
        RHOH effectors [cytosol] (Bos taurus)
        
        LCK [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:Q3ZCM0

Gene Names

LCK

Reference Genes

BioGPS Gene:508890 LCK

ENSEMBL:ENSBTAG00000012695.5

KEGG:bta:508890 LCK

Monarch:508890 LCK

NCBI Gene:508890 LCK

UCSC:Q3ZCM0 LCK

Reference Transcript

RefSeq:NM_001034334.1 LCK

Participates

as a member of

as an input of

Active FLT3 binds to LCK (Bos taurus)

as a component of

as a candidate of

SHC kinases in IL2 signaling [cytosol] (Bos taurus)

Other forms of this molecule

phospho-LCK [plasma membrane]

phospho-LCK [cytosol]

Inferred From

LCK [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001029506.1

VGNC

30810

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