Reactome | GNA15 [plasma membrane]

GNA15 [plasma membrane]

Stable Identifier

R-BTA-167450

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

plasma membrane

Synonyms

GNA15, F1N2V3

Locations in the PathwayBrowser

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Hemostasis (Bos taurus)

- Platelet activation, signaling and aggregation (Bos taurus)
  - Signal amplification (Bos taurus)
    - ADP signalling through P2Y purinoceptor 1 (Bos taurus)
      - Dissociation of the P2Y purinoceptor 1:Gq complex (Bos taurus)
        
        ADP:P2RY1:G-protein Gq (active) [plasma membrane] (Bos taurus)
        
        G protein-GTP [plasma membrane] (Bos taurus)
        
        G protein alpha:GTP complex [plasma membrane] (Bos taurus)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Bos taurus)
        
        GNA15 [plasma membrane] (Bos taurus)
        
        G protein alpha:GTP complex [plasma membrane] (Bos taurus)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Bos taurus)
        
        GNA15 [plasma membrane] (Bos taurus)
      - P2Y purinoceptor 1 activates MAP kinase p38 alpha (Bos taurus)
        
        G protein alpha:GTP complex [plasma membrane] (Bos taurus)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Bos taurus)
        
        GNA15 [plasma membrane] (Bos taurus)
    - Thromboxane signalling through TP receptor (Bos taurus)
      - Activated TP receptor binds G-proten Gq (Bos taurus)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Bos taurus)
        
        G-protein alpha (q/11):GDP [plasma membrane] (Bos taurus)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Bos taurus)
        
        GNA15 [plasma membrane] (Bos taurus)
        
        TP receptor:Thromboxane A2:G-protein Gq (inactive) [plasma membrane] (Bos taurus)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Bos taurus)
        
        G-protein alpha (q/11):GDP [plasma membrane] (Bos taurus)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Bos taurus)
        
        GNA15 [plasma membrane] (Bos taurus)
      - Dissociation of the TP:Gq complex (Bos taurus)
        
        G protein alpha:GTP complex [plasma membrane] (Bos taurus)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Bos taurus)
        
        GNA15 [plasma membrane] (Bos taurus)
        
        TP receptor:Thromboxane A2:G-protein Gq (active) [plasma membrane] (Bos taurus)
        
        G protein-GTP [plasma membrane] (Bos taurus)
        
        G protein alpha:GTP complex [plasma membrane] (Bos taurus)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Bos taurus)
        
        GNA15 [plasma membrane] (Bos taurus)
      - Gq activation by TP receptor (Bos taurus)
        
        TP receptor:Thromboxane A2:G-protein Gq (active) [plasma membrane] (Bos taurus)
        
        G protein-GTP [plasma membrane] (Bos taurus)
        
        G protein alpha:GTP complex [plasma membrane] (Bos taurus)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Bos taurus)
        
        GNA15 [plasma membrane] (Bos taurus)
        
        TP receptor:Thromboxane A2:G-protein Gq (inactive) [plasma membrane] (Bos taurus)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Bos taurus)
        
        G-protein alpha (q/11):GDP [plasma membrane] (Bos taurus)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Bos taurus)
        
        GNA15 [plasma membrane] (Bos taurus)
  - Thrombin signalling through proteinase activated receptors (PARs) (Bos taurus)
    - Thrombin-activated PARs activate Gq (Bos taurus)
      - Thrombin-activated PAR:Gq (active) [plasma membrane] (Bos taurus)
        
        G protein-GTP [plasma membrane] (Bos taurus)
        
        G protein alpha:GTP complex [plasma membrane] (Bos taurus)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Bos taurus)
        
        GNA15 [plasma membrane] (Bos taurus)
      - Thrombin-activated PARs:Gq (inactive) [plasma membrane] (Bos taurus)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Bos taurus)
        
        G-protein alpha (q/11):GDP [plasma membrane] (Bos taurus)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Bos taurus)
        
        GNA15 [plasma membrane] (Bos taurus)
    - Thrombin-activated PARs binds G-protein Gq (Bos taurus)
      - Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Bos taurus)
        
        G-protein alpha (q/11):GDP [plasma membrane] (Bos taurus)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Bos taurus)
        
        GNA15 [plasma membrane] (Bos taurus)
      - Thrombin-activated PARs:Gq (inactive) [plasma membrane] (Bos taurus)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Bos taurus)
        
        G-protein alpha (q/11):GDP [plasma membrane] (Bos taurus)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Bos taurus)
        
        GNA15 [plasma membrane] (Bos taurus)
    - Thrombin-activated PARs:Gq (active) dissociate (Bos taurus)
      - G protein alpha:GTP complex [plasma membrane] (Bos taurus)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Bos taurus)
        
        GNA15 [plasma membrane] (Bos taurus)
      - Thrombin-activated PAR:Gq (active) [plasma membrane] (Bos taurus)
        
        G protein-GTP [plasma membrane] (Bos taurus)
        
        G protein alpha:GTP complex [plasma membrane] (Bos taurus)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Bos taurus)
        
        GNA15 [plasma membrane] (Bos taurus)

External Reference Information

External Reference

UniProt:F1N2V3

Gene Names

GNA15

Reference Genes

BioGPS Gene:532029 GNA15

ENSEMBL:ENSBTAG00000019988.6

KEGG Gene (Bos taurus):532029 GNA15

Monarch:532029 GNA15

NCBI Gene:532029 GNA15

Reference Transcript

RefSeq:NM_001192714.1 GNA15

Other Identifiers

532029

GO:0000166

GO:0001508

GO:0001664

GO:0003824

GO:0003924

GO:0005525

GO:0005834

GO:0005886

GO:0007165

GO:0007186

GO:0007188

GO:0016787

GO:0019001

GO:0023052

GO:0031683

GO:0060158

Participates

as a candidate of

G(q) alpha 11,14,15,Q [plasma membrane] (Bos taurus)

as a member of

G-protein alpha (q/11/14/15) [plasma membrane] (Bos taurus)

Inferred From

GNA15 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_001179643.1

OpenTargets

ENSG00000060558

Ensembl

ENSBTAG00000019988, ENSBTAP00000026624, ENSBTAT00000026624

VGNC

29448

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