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TRAF6 [cytosol]
Stable Identifier
R-BTA-166366
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
TRAF6, Q3ZCC3
Locations in the PathwayBrowser
Expand all
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
TCR signaling (Bos taurus)
Downstream TCR signaling (Bos taurus)
Translocation of TRAF6 to CBM complex (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
TRAF6 trimer bound to CBM complex [plasma membrane] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
Signaling by Interleukins (Bos taurus)
Interleukin-1 family signaling (Bos taurus)
Interleukin-1 signaling (Bos taurus)
Hyperphosphorylated IRAK1 associates with TRAF6 (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
IRAK1 induces oligomerisation of TRAF6 (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
hp-IRAK1:3xTRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
p-2S,S376,T,T209,T387-IRAK1:TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
p-2S,S376,T,T209,T387-IRAK1:TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
TRAF2,6 ubiquitinates NLRC5 (Bos taurus)
TRAF2, TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
TRAF6 binding leads to IRAK1:TRAF6 release (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
p-2S,S376,T,T209,T387-IRAK1:TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
TRAF6 is K63 poly-ubiquitinated (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
hp-IRAK1:3xTRAF6:3xUBE2N:UBE2V1:K63polyUb [cytosol] (Bos taurus)
hp-IRAK1:3xTRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
p-2S,S376,T,T209,T387-IRAK1:TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
p62:MEKK3 binds to TRAF6 (Bos taurus)
MAP3K3:SQSTM1:TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
Innate Immune System (Bos taurus)
Alpha-protein kinase 1 signaling pathway (Bos taurus)
ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Bos taurus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Bos taurus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 oligomer [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Bos taurus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 oligomer [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
C-type lectin receptors (CLRs) (Bos taurus)
CLEC7A (Dectin-1) signaling (Bos taurus)
TRAF6 binds MALT1 oligomers (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
p-T231-CARD9:BCL10:MALT1 oligomers:TRAF6 [plasma membrane] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
TRAF6 oligomerizes (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
p-T231-CARD9:BCL10:MALT1 oligomers:TRAF6 [plasma membrane] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
p-T231-CARD9:BCL10:MALT1:TRAF6 oligomers [plasma membrane] (Bos taurus)
TRAF6 oligomer [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
Fc epsilon receptor (FCERI) signaling (Bos taurus)
FCERI mediated NF-kB activation (Bos taurus)
Oligomerization of TRAF6 (Bos taurus)
DAG:p-5Y-PKC-theta:CBM oligomer:TRAF6 [plasma membrane] (Bos taurus)
CBM oligomer:TRAF6 [plasma membrane] (Bos taurus)
BCL10 oligomer:MALT1 oligomer:TRAF6 [cytosol] (Bos taurus)
MALT1oligomer:TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
DAG:p-5Y-PKC-theta:CBM oligomer:TRAF6 oligomer [plasma membrane] (Bos taurus)
CBM oligomer:TRAF6 oligomer [plasma membrane] (Bos taurus)
TRAF6 oligomer [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
Recruitment of TRAF6 to CBM complex by binding to MALT1 (Bos taurus)
DAG:p-5Y-PKC-theta:CBM oligomer:TRAF6 [plasma membrane] (Bos taurus)
CBM oligomer:TRAF6 [plasma membrane] (Bos taurus)
BCL10 oligomer:MALT1 oligomer:TRAF6 [cytosol] (Bos taurus)
MALT1oligomer:TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
Toll-like Receptor Cascades (Bos taurus)
Toll Like Receptor 10 (TLR10) Cascade (Bos taurus)
MyD88 cascade initiated on plasma membrane (Bos taurus)
IRAK1 recruits IKK complex (Bos taurus)
NEMO subunit of IKK complex binds to activated IRAK1 (Bos taurus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Bos taurus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
IRAK2 mediated activation of TAK1 complex (Bos taurus)
IRAK2 induces TRAF6 oligomerization (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
TRAF2,6 ubiquitinates NLRC5 (Bos taurus)
TRAF2, TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
TRAF6 binds MEKK1 (Bos taurus)
MEKK1:activated TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
Toll Like Receptor 2 (TLR2) Cascade (Bos taurus)
Toll Like Receptor TLR1:TLR2 Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
IRAK1 recruits IKK complex (Bos taurus)
NEMO subunit of IKK complex binds to activated IRAK1 (Bos taurus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Bos taurus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
IRAK2 mediated activation of TAK1 complex (Bos taurus)
IRAK2 induces TRAF6 oligomerization (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
TRAF2,6 ubiquitinates NLRC5 (Bos taurus)
TRAF2, TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
TRAF6 binds MEKK1 (Bos taurus)
MEKK1:activated TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
Toll Like Receptor TLR6:TLR2 Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
IRAK1 recruits IKK complex (Bos taurus)
NEMO subunit of IKK complex binds to activated IRAK1 (Bos taurus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Bos taurus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
IRAK2 mediated activation of TAK1 complex (Bos taurus)
IRAK2 induces TRAF6 oligomerization (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
TRAF2,6 ubiquitinates NLRC5 (Bos taurus)
TRAF2, TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
TRAF6 binds MEKK1 (Bos taurus)
MEKK1:activated TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
Toll Like Receptor 3 (TLR3) Cascade (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
TRAF2,6 ubiquitinates NLRC5 (Bos taurus)
TRAF2, TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
Toll Like Receptor 4 (TLR4) Cascade (Bos taurus)
MyD88-independent TLR4 cascade (Bos taurus)
TRIF (TICAM1)-mediated TLR4 signaling (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
TRAF2,6 ubiquitinates NLRC5 (Bos taurus)
TRAF2, TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
TRAF6-mediated induction of TAK1 complex within TLR4 complex (Bos taurus)
Activated TLR4:TICAM1 recruits TRAF6 (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
Auto ubiquitination of TRAF6 bound to the activated TLR4 complex (Bos taurus)
TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
IRAK1 recruits IKK complex (Bos taurus)
NEMO subunit of IKK complex binds to activated IRAK1 (Bos taurus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Bos taurus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
IRAK2 mediated activation of TAK1 complex (Bos taurus)
IRAK2 induces TRAF6 oligomerization (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
TRAF2,6 ubiquitinates NLRC5 (Bos taurus)
TRAF2, TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
TRAF6 binds MEKK1 (Bos taurus)
MEKK1:activated TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
Toll Like Receptor 5 (TLR5) Cascade (Bos taurus)
MyD88 cascade initiated on plasma membrane (Bos taurus)
IRAK1 recruits IKK complex (Bos taurus)
NEMO subunit of IKK complex binds to activated IRAK1 (Bos taurus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Bos taurus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
IRAK2 mediated activation of TAK1 complex (Bos taurus)
IRAK2 induces TRAF6 oligomerization (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
TRAF2,6 ubiquitinates NLRC5 (Bos taurus)
TRAF2, TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
TRAF6 binds MEKK1 (Bos taurus)
MEKK1:activated TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Bos taurus)
MyD88 dependent cascade initiated on endosome (Bos taurus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Bos taurus)
IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
TRAF2,6 ubiquitinates NLRC5 (Bos taurus)
TRAF2, TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
TRAF6 binds MEKK1 (Bos taurus)
MEKK1:activated TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
Toll Like Receptor 9 (TLR9) Cascade (Bos taurus)
MyD88 dependent cascade initiated on endosome (Bos taurus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Bos taurus)
IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
TRAF2,6 ubiquitinates NLRC5 (Bos taurus)
TRAF2, TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
TRAF6 binds MEKK1 (Bos taurus)
MEKK1:activated TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
Deubiquitination (Bos taurus)
Ovarian tumor domain proteases (Bos taurus)
OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Bos taurus)
OTUB1,(OTUB2):RNF128,TRAF3,TRAF6,RHOA,TP53 [cytosol] (Bos taurus)
RNF128,TRAF3,TRAF6,RHOA,TP53 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
RNF128,TRAF3,TRAF6,RHOA,TP53 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Bos taurus)
OTUD7B,TNFAIP3,ZRANB1:TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Bos taurus)
OTUD7B,TNFAIP3,ZRANB1:TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
Ub-specific processing proteases (Bos taurus)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Bos taurus)
TRAF2,TRAF6,IKBKG,RIPK1 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
USP4 deubiquitinate TRAF2,TRAF6 (Bos taurus)
TRAF2, TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Death Receptor Signaling (Bos taurus)
p75 NTR receptor-mediated signalling (Bos taurus)
Cell death signalling via NRAGE, NRIF and NADE (Bos taurus)
NRIF signals cell death from the nucleus (Bos taurus)
TRAF6 binds to p75NTR:NRIF (Bos taurus)
NGF ligand:p75NTR:NRIF:TRAF6 [plasma membrane] (Bos taurus)
TRAF6 homotrimer [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
TRAF6 homotrimer [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
TRAF6 polyubiquitinates NRIF (Bos taurus)
TRAF6 homotrimer [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Bos taurus)
NGF ligand:p75NTR:NRIF:TRAF6 [plasma membrane] (Bos taurus)
TRAF6 homotrimer [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
TRAF6 homotrimer [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
Regulated proteolysis of p75NTR (Bos taurus)
p75NTR ICD signals to NF-kB (Bos taurus)
NF-kB:p75NTR ICD:TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
p75NTR signals via NF-kB (Bos taurus)
NF-kB is activated and signals survival (Bos taurus)
IKKbeta is activated (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
IKKbeta phosphorylates IkB causing NF-kB to dissociate (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
p75NTR recruits signalling complexes (Bos taurus)
IKK-beta is recruited (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
IRAK interacts with TRAF6 (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
MYD88 dissociates (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
TRAF6 is auto-ubiquitinated (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
p62 is recruited and forms a complex with TRAF6 (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
p62 recruits an atypical PKC (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:aPKCi [plasma membrane] (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
Intracellular signaling by second messengers (Bos taurus)
PIP3 activates AKT signaling (Bos taurus)
Negative regulation of the PI3K/AKT network (Bos taurus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:Q3ZCC3
Gene Names
TRAF6
Reference Genes
BioGPS Gene:539124 TRAF6
ENSEMBL:ENSBTAG00000036009
KEGG:bta:539124 TRAF6
Monarch:539124 TRAF6
NCBI Entrez Gene:539124 TRAF6
UCSC:Q3ZCC3 TRAF6
Reference Transcript
RefSeq:XM_005216385.5 TRAF6
RefSeq:NM_001034661.2 TRAF6
RefSeq:XM_005216384.5 TRAF6
Other Identifiers
539124
782032
Bt.20349.1.S1_at
Bt.20349.2.S1_at
GO:0000045
GO:0000122
GO:0000209
GO:0001503
GO:0001701
GO:0001843
GO:0002376
GO:0002637
GO:0002726
GO:0002753
GO:0003824
GO:0004842
GO:0005164
GO:0005515
GO:0005634
GO:0005737
GO:0005811
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006955
GO:0007165
GO:0007249
GO:0008270
GO:0009299
GO:0009887
GO:0009898
GO:0016071
GO:0016567
GO:0016740
GO:0019886
GO:0023035
GO:0030154
GO:0030316
GO:0030674
GO:0031624
GO:0031663
GO:0031666
GO:0032481
GO:0032735
GO:0032743
GO:0032755
GO:0032991
GO:0033209
GO:0034142
GO:0034450
GO:0035631
GO:0038061
GO:0038172
GO:0038173
GO:0042088
GO:0042102
GO:0042475
GO:0042742
GO:0042802
GO:0042826
GO:0042981
GO:0043011
GO:0043122
GO:0043123
GO:0043124
GO:0043226
GO:0043422
GO:0045453
GO:0045672
GO:0045892
GO:0045944
GO:0046330
GO:0046849
GO:0048468
GO:0048471
GO:0048856
GO:0050852
GO:0051865
GO:0060090
GO:0061630
GO:0070498
GO:0070534
GO:0070555
GO:0070936
GO:0071222
GO:0071345
GO:0097400
GO:0098542
GO:0098696
GO:0098978
GO:0140096
GO:0140374
GO:0141198
GO:1904996
Participates
as a member of
RNF128,TRAF3,TRAF6,RHOA,TP53 [cytosol] (Bos taurus)
TRAF2,TRAF6,IKBKG,RIPK1 [cytosol] (Bos taurus)
TRAF2, TRAF6 [cytosol] (Bos taurus)
as a component of
OTUD7B,TNFAIP3,ZRANB1:TRAF6 [cytosol] (Bos taurus)
TRAF6 homotrimer [cytosol] (Bos taurus)
NF-kB:p75NTR ICD:TRAF6 [cytosol] (Bos taurus)
hp-IRAK1:3xTRAF6 [cytosol] (Bos taurus)
p-2S,S376,T,T209,T387-IRAK1:TRAF6 [cytosol] (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane] (Bos taurus)
p-T231-CARD9:BCL10:MALT1 oligomers:TRAF6 [plasma membrane] (Bos taurus)
MALT1oligomer:TRAF6 [cytosol] (Bos taurus)
MAP3K3:SQSTM1:TRAF6 [cytosol] (Bos taurus)
MEKK1:activated TRAF6 [cytosol] (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Bos taurus)
TRAF6 trimer bound to CBM complex [plasma membrane] (Bos taurus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Bos taurus)
TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Bos taurus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 [cytosol] (Bos taurus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 oligomer [cytosol] (Bos taurus)
IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Bos taurus)
as an input of
p75NTR ICD signals to NF-kB (Bos taurus)
IRAK1 induces oligomerisation of TRAF6 (Bos taurus)
Hyperphosphorylated IRAK1 associates with TRAF6 (Bos taurus)
TRAF6 oligomerizes (Bos taurus)
TRAF6 binds MALT1 oligomers (Bos taurus)
Oligomerization of TRAF6 (Bos taurus)
Recruitment of TRAF6 to CBM complex by binding to MALT1 (Bos taurus)
p62:MEKK3 binds to TRAF6 (Bos taurus)
TRAF6 binds MEKK1 (Bos taurus)
IRAK interacts with TRAF6 (Bos taurus)
IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Bos taurus)
Translocation of TRAF6 to CBM complex (Bos taurus)
Activated TLR4:TICAM1 recruits TRAF6 (Bos taurus)
TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Bos taurus)
ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Bos taurus)
IRAK2 induces TRAF6 oligomerization (Bos taurus)
as a repeated unit of
TRAF6 oligomer [cytosol] (Bos taurus)
Other forms of this molecule
TRAF6 [cytosol]
TRAF6 [cytosol]
TRAF6 [endosome membrane]
TRAF6 [endosome membrane]
TRAF6 [plasma membrane]
TRAF6 [plasma membrane]
TRAF6 [cytosol]
Inferred From
TRAF6 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_005216442.1
,
XP_005216441.1
,
NP_001029833.1
ENSEMBL
ENSBTAT00000021630
,
ENSBTAG00000036009
,
ENSBTAP00000021630
IntEnz
2.3.2.27
VGNC
36278
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