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phospho-IRF3 [cytosol]
Stable Identifier
R-BTA-166258
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
p-4S,T404-IRF3, Q4JF28
Locations in the PathwayBrowser
Expand all
Immune System (Bos taurus)
Innate Immune System (Bos taurus)
Cytosolic sensors of pathogen-associated DNA (Bos taurus)
STING mediated induction of host immune responses (Bos taurus)
IRF3-mediated induction of type I IFN (Bos taurus)
Dimerized phospho-IRF3 migrates to the nucleus (Bos taurus)
p-T,4S-IRF3:p-T,4S-IRF3 [cytosol] (Bos taurus)
phospho-IRF3 [cytosol] (Bos taurus)
IRF3 is phosphorylated by TBK1 (Bos taurus)
phospho-IRF3 [cytosol] (Bos taurus)
p-T,4S-IRF3 is dimerized (Bos taurus)
p-T,4S-IRF3:p-T,4S-IRF3 [cytosol] (Bos taurus)
phospho-IRF3 [cytosol] (Bos taurus)
phospho-IRF3 [cytosol] (Bos taurus)
ZBP1(DAI) mediated induction of type I IFNs (Bos taurus)
IRF3 mediated activation of type 1 IFN (Bos taurus)
Dimerized phospho-IRF3 migrates to the nucleus (Bos taurus)
p-T,4S-IRF3:p-T,4S-IRF3 [cytosol] (Bos taurus)
phospho-IRF3 [cytosol] (Bos taurus)
p-T,4S-IRF3 is dimerized (Bos taurus)
p-T,4S-IRF3:p-T,4S-IRF3 [cytosol] (Bos taurus)
phospho-IRF3 [cytosol] (Bos taurus)
phospho-IRF3 [cytosol] (Bos taurus)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Bos taurus)
TRAF3-dependent IRF activation pathway (Bos taurus)
Dimerization of Phospho IRF3 or phospho IRF7 (Bos taurus)
IRF3-P:IRF7-P [cytosol] (Bos taurus)
phospho-IRF3 [cytosol] (Bos taurus)
p-4S,T404-IRF3,p-S477,S479-IRF7 [cytosol] (Bos taurus)
phospho-IRF3 [cytosol] (Bos taurus)
p-T,4S-IRF3:p-T,4S-IRF3 [cytosol] (Bos taurus)
phospho-IRF3 [cytosol] (Bos taurus)
Translocation of phosphorylated IRF3,IRF7 dimers into nucleus (Bos taurus)
IRF3-P:IRF7-P [cytosol] (Bos taurus)
phospho-IRF3 [cytosol] (Bos taurus)
p-T,4S-IRF3:p-T,4S-IRF3 [cytosol] (Bos taurus)
phospho-IRF3 [cytosol] (Bos taurus)
Toll-like Receptor Cascades (Bos taurus)
Toll Like Receptor 3 (TLR3) Cascade (Bos taurus)
TICAM1-dependent activation of IRF3/IRF7 (Bos taurus)
Dimerization of phosphorylated IRF3/IRF7 (Bos taurus)
p-4S,T404-IRF3,p-S477,S479-IRF7 [cytosol] (Bos taurus)
phospho-IRF3 [cytosol] (Bos taurus)
phosphorylated IRF3 and/or IRF7 dimer [cytosol] (Bos taurus)
p-T,4S-IRF3:p-T,4S-IRF3 [cytosol] (Bos taurus)
phospho-IRF3 [cytosol] (Bos taurus)
Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Bos taurus)
phosphorylated IRF3 and/or IRF7 dimer [cytosol] (Bos taurus)
p-T,4S-IRF3:p-T,4S-IRF3 [cytosol] (Bos taurus)
phospho-IRF3 [cytosol] (Bos taurus)
Toll Like Receptor 4 (TLR4) Cascade (Bos taurus)
MyD88-independent TLR4 cascade (Bos taurus)
TRIF (TICAM1)-mediated TLR4 signaling (Bos taurus)
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (Bos taurus)
Dimerization of phosphorylated IRF3/IRF7 (Bos taurus)
p-4S,T404-IRF3,p-S477,S479-IRF7 [cytosol] (Bos taurus)
phospho-IRF3 [cytosol] (Bos taurus)
phosphorylated IRF3 and/or IRF7 dimer [cytosol] (Bos taurus)
p-T,4S-IRF3:p-T,4S-IRF3 [cytosol] (Bos taurus)
phospho-IRF3 [cytosol] (Bos taurus)
Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Bos taurus)
phosphorylated IRF3 and/or IRF7 dimer [cytosol] (Bos taurus)
p-T,4S-IRF3:p-T,4S-IRF3 [cytosol] (Bos taurus)
phospho-IRF3 [cytosol] (Bos taurus)
Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex (Bos taurus)
p-4S,T404-IRF3,p-S477,S479-IRF7 [cytosol] (Bos taurus)
phospho-IRF3 [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:Q4JF28
Gene Names
IRF3
Reference Genes
BioGPS Gene:516979 IRF3
ENSEMBL:ENSBTAG00000006633
ENSEMBL:ENSBTAG00000006633.5 IRF3
KEGG Gene (Bos taurus):516979 IRF3
Monarch:516979 IRF3
NCBI Gene:516979 IRF3
Reference Transcript
RefSeq:NM_001029845.3 IRF3
Other Identifiers
516979
GO:0000976
GO:0003677
GO:0003700
GO:0006351
GO:0006355
GO:0006357
GO:0045893
GO:0140110
Participates
as an input of
p-T,4S-IRF3 is dimerized (Bos taurus)
as an output of
IRF3 is phosphorylated by TBK1 (Bos taurus)
as a member of
p-4S,T404-IRF3,p-S477,S479-IRF7 [cytosol] (Bos taurus)
as a component of
IRF3-P:IRF7-P [cytosol] (Bos taurus)
p-T,4S-IRF3:p-T,4S-IRF3 [cytosol] (Bos taurus)
Other forms of this molecule
phospho-IRF3 [nucleoplasm]
phospho-IRF3 [nucleoplasm]
IRF3 [cytosol]
Inferred From
p-4S,T404-IRF3 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 396 (in Homo sapiens)
Coordinate
396
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 398 (in Homo sapiens)
Coordinate
398
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 402 (in Homo sapiens)
Coordinate
402
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 405 (in Homo sapiens)
Coordinate
405
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 404 (in Homo sapiens)
Coordinate
404
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_001025016.1
OpenTargets
ENSG00000126456
Ensembl
ENSBTAG00000006633
,
ENSBTAT00000031869
,
ENSBTAP00000031815
VGNC
30274
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