Reactome | NDUFB2 [mitochondrial inner membrane]

NDUFB2 [mitochondrial inner membrane]

Stable Identifier

R-BTA-163941

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

mitochondrial inner membrane

Synonyms

NDUFB2, Q02374

Locations in the PathwayBrowser

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Metabolism (Bos taurus)

- Aerobic respiration and respiratory electron transport (Bos taurus)
  - Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Bos taurus)
    - Respiratory electron transport (Bos taurus)
      - Complex I biogenesis (Bos taurus)
        
        Intermediate 1 binds HP subcomplex to form Intermediate 2 (Bos taurus)
        
        HP subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        NDUFB2 [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        HP subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        NDUFB2 [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        HP subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        NDUFB2 [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        HP subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        NDUFB2 [mitochondrial inner membrane] (Bos taurus)
        
        ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Bos taurus)
        
        550kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        HP subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        NDUFB2 [mitochondrial inner membrane] (Bos taurus)
        
        815kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        550kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        HP subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        NDUFB2 [mitochondrial inner membrane] (Bos taurus)
        
        Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Bos taurus)
        
        815kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        550kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        HP subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        NDUFB2 [mitochondrial inner membrane] (Bos taurus)
        
        980kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        815kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        550kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        HP subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        NDUFB2 [mitochondrial inner membrane] (Bos taurus)
        
        The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        HP subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        NDUFB2 [mitochondrial inner membrane] (Bos taurus)
        
        550kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        HP subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        NDUFB2 [mitochondrial inner membrane] (Bos taurus)
        
        The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Bos taurus)
        
        980kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        815kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        550kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        HP subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        NDUFB2 [mitochondrial inner membrane] (Bos taurus)
        
        Complex I [mitochondrial inner membrane] (Bos taurus)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        HP subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        NDUFB2 [mitochondrial inner membrane] (Bos taurus)
      - Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Bos taurus)
        
        Complex I [mitochondrial inner membrane] (Bos taurus)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        HP subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        NDUFB2 [mitochondrial inner membrane] (Bos taurus)

External Reference Information

External Reference

UniProt:Q02374

Gene Names

NDUFB2

Reference Genes

BioGPS Gene:327713 NDUFB2

ENSEMBL:ENSBTAG00000021759

ENSEMBL:ENSBTAG00000021759.6 NDUFB2

KEGG Gene (Bos taurus):327713 NDUFB2

Monarch:327713 NDUFB2

NCBI Gene:327713 NDUFB2

Reference Transcript

RefSeq:NM_175828.2 NDUFB2

Other Identifiers

327713

GO:0005739

GO:0005743

GO:0005747

GO:0007005

GO:0016020

GO:0032981

GO:0043226

GO:0065003

GO:0070469

Participates

as a component of

HP subcomplex [mitochondrial inner membrane] (Bos taurus)

Inferred From

NDUFB2 [mitochondrial inner membrane] (Homo sapiens)

Cross References

RefSeq

NP_787022.1

OpenTargets

ENSG00000090266

Ensembl

ENSBTAP00000029003, ENSBTAG00000021759, ENSBTAT00000029003

VGNC

31962

PDB

7QSO, 7R4G, 7R44, 7DGR, 7QSK, 7R41, 7DGS, 7QSL, 7R4C, 7R46, 7R45, 7DKF, 7DH0, 7QSM, 7R4D, 7R47, 7QSD, 7R42, 7R48, 7QSN, 7DGZ, 7R4F, 7R43, 7DGQ

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