Reactome | NDUFC1 [mitochondrial inner membrane]

NDUFC1 [mitochondrial inner membrane]

Stable Identifier

R-BTA-163940

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

mitochondrial inner membrane

Synonyms

NDUFC1, Q02376

Locations in the PathwayBrowser

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Metabolism (Bos taurus)

- Aerobic respiration and respiratory electron transport (Bos taurus)
  - Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Bos taurus)
    - Respiratory electron transport (Bos taurus)
      - Complex I biogenesis (Bos taurus)
        
        Intermediate 1 binds HP subcomplex to form Intermediate 2 (Bos taurus)
        
        HP subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        NDUFC1 [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        HP subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        NDUFC1 [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        HP subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        NDUFC1 [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        HP subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        NDUFC1 [mitochondrial inner membrane] (Bos taurus)
        
        ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Bos taurus)
        
        550kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        HP subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        NDUFC1 [mitochondrial inner membrane] (Bos taurus)
        
        815kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        550kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        HP subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        NDUFC1 [mitochondrial inner membrane] (Bos taurus)
        
        Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Bos taurus)
        
        815kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        550kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        HP subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        NDUFC1 [mitochondrial inner membrane] (Bos taurus)
        
        980kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        815kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        550kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        HP subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        NDUFC1 [mitochondrial inner membrane] (Bos taurus)
        
        The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        HP subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        NDUFC1 [mitochondrial inner membrane] (Bos taurus)
        
        550kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        HP subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        NDUFC1 [mitochondrial inner membrane] (Bos taurus)
        
        The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Bos taurus)
        
        980kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        815kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        550kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        HP subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        NDUFC1 [mitochondrial inner membrane] (Bos taurus)
        
        Complex I [mitochondrial inner membrane] (Bos taurus)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        HP subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        NDUFC1 [mitochondrial inner membrane] (Bos taurus)
      - Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Bos taurus)
        
        Complex I [mitochondrial inner membrane] (Bos taurus)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        HP subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        NDUFC1 [mitochondrial inner membrane] (Bos taurus)

External Reference Information

External Reference

UniProt:Q02376

Gene Names

NDUFC1

Reference Genes

BioGPS Gene:282289 NDUFC1

ENSEMBL:ENSBTAG00000039582

ENSEMBL:ENSBTAG00000039582.2 NDUFC1

KEGG Gene (Bos taurus):282289 NDUFC1

Monarch:282289 NDUFC1

NCBI Gene:282289 NDUFC1

Reference Transcript

Other Identifiers

282289

GO:0005739

GO:0005743

GO:0005747

GO:0007005

GO:0016020

GO:0032981

GO:0043226

GO:0065003

GO:0070469

Participates

as a component of

HP subcomplex [mitochondrial inner membrane] (Bos taurus)

Inferred From

NDUFC1 [mitochondrial inner membrane] (Homo sapiens)

Cross References

RefSeq

NP_776989.1, XP_005217593.1

OpenTargets

ENSG00000109390

Ensembl

ENSBTAT00000055713, ENSBTAG00000039582, ENSBTAP00000051891

VGNC

31968

PDB

5O31, 7DGQ, 7R44, 7QSN, 7QSO, 7DGR, 7R4F, 7R4D, 7QSM, 7R43, 7QSL, 7R4C, 7R42, 7QSK, 7R41, 7R48, 5LDW, 7DH0, 5LDX, 7DGZ, 7R47, 7QSD, 7DKF, 7R46, 5LNK, 7R4G, 7DGS, 7R45, 5LC5

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