Reactome | SP1 [nucleoplasm]

SP1 [nucleoplasm]

Stable Identifier

R-BTA-1592223

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

nucleoplasm

Synonyms

SP1, A0JNC9

Locations in the PathwayBrowser

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Cell-Cell communication (Bos taurus)

- Cell junction organization (Bos taurus)
  - Cell-cell junction organization (Bos taurus)
    - Adherens junctions interactions (Bos taurus)
      - Regulation of Homotypic Cell-Cell Adhesion (Bos taurus)
        
        Regulation of Expression and Function of Type II Classical Cadherins (Bos taurus)
        
        Regulation of CDH11 Expression and Function (Bos taurus)
        
        Regulation of CDH11 gene transcription (Bos taurus)
        
        ZEB2 binds SP1 (Bos taurus)
        
        SP1 [nucleoplasm] (Bos taurus)
        
        ZEB2:SP1 [nucleoplasm] (Bos taurus)
        
        SP1 [nucleoplasm] (Bos taurus)

Gene expression (Transcription) (Bos taurus)

- RNA Polymerase II Transcription (Bos taurus)
  - Generic Transcription Pathway (Bos taurus)
    - Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Bos taurus)
      - SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Bos taurus)
        
        SMAD2/3:SMAD4 heterotrimer binds SP1 (Bos taurus)
        
        SP1 [nucleoplasm] (Bos taurus)
        
        p-2S-SMAD2,3:SMAD4:SP1 [nucleoplasm] (Bos taurus)
        
        SP1 [nucleoplasm] (Bos taurus)
  - RNA polymerase II transcribes snRNA genes (Bos taurus)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Bos taurus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        SP1 [nucleoplasm] (Bos taurus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        SP1 [nucleoplasm] (Bos taurus)
    - CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Bos taurus)
      - RNA polymerase II (phosphoserine-5,7):Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        SP1 [nucleoplasm] (Bos taurus)
      - RNA polymerase II (unphosphorylated):Initiation factors at promoter of snRNA gene [nucleoplasm] (Bos taurus)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        SP1 [nucleoplasm] (Bos taurus)
    - General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Bos taurus)
      - Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        SP1 [nucleoplasm] (Bos taurus)
      - SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        SP1 [nucleoplasm] (Bos taurus)
    - Integrator complex processes the 3' end of snRNA (Bos taurus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        SP1 [nucleoplasm] (Bos taurus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        SP1 [nucleoplasm] (Bos taurus)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Bos taurus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        SP1 [nucleoplasm] (Bos taurus)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        SP1 [nucleoplasm] (Bos taurus)
    - Pre-snRNA transcript initiation, Integrator binding, LEC binding (Bos taurus)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        SP1 [nucleoplasm] (Bos taurus)
      - RPAP2:RPRD1A,B:RPRD2:RNA polymerase II (phosphoserine-5,7):Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        SP1 [nucleoplasm] (Bos taurus)
    - RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Bos taurus)
      - Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        SP1 [nucleoplasm] (Bos taurus)
      - RNA polymerase II (unphosphorylated):Initiation factors at promoter of snRNA gene [nucleoplasm] (Bos taurus)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        SP1 [nucleoplasm] (Bos taurus)
    - RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Bos taurus)
      - RNA polymerase II (phosphoserine-5,7):Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        SP1 [nucleoplasm] (Bos taurus)
      - RPAP2:RPRD1A,B:RPRD2:RNA polymerase II (phosphoserine-5,7):Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        SP1 [nucleoplasm] (Bos taurus)
    - SNAPc binds PSE of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Bos taurus)
      - POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        SP1 [nucleoplasm] (Bos taurus)
      - SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        SP1 [nucleoplasm] (Bos taurus)

External Reference Information

External Reference

UniProt:A0JNC9

Gene Names

SP1

Reference Genes

BioGPS Gene:540741 SP1

ENSEMBL:ENSBTAG00000003021.5

KEGG:bta:540741 SP1

Monarch:540741 SP1

NCBI Gene:540741 SP1

UCSC:A0JNC9 SP1

Reference Transcript

RefSeq:NM_001078027.1 SP1

Other Identifiers

540741

Bt.21241.1.S1_at

GO:0000785

GO:0000791

GO:0000976

GO:0000977

GO:0000978

GO:0000981

GO:0001221

GO:0001228

GO:0003677

GO:0003690

GO:0003700

GO:0005634

GO:0005654

GO:0006355

GO:0006357

GO:0008270

GO:0010628

GO:0017053

GO:0042802

GO:0042803

GO:0042826

GO:0043226

GO:0043536

GO:0043565

GO:0043923

GO:0045766

GO:0045893

GO:0045944

GO:0140110

GO:1902004

GO:1904828

GO:1905564

GO:1990837

GO:2001235

Participates

as an input of

as a component of

Inferred From

SP1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001071495.1

ENSEMBL

ENSBTAP00000003929, ENSBTAT00000003929, ENSBTAG00000003021

VGNC

35152

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