Reactome | IGHE [extracellular region]

IGHE [extracellular region]

Stable Identifier

R-BTA-1478806

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

extracellular region

Synonyms

G3N342

Locations in the PathwayBrowser

Expand all

Immune System (Bos taurus)

- Innate Immune System (Bos taurus)
  - Fc epsilon receptor (FCERI) signaling (Bos taurus)
    - Allergen dependent IgE bound FCERI aggregation (Bos taurus)
      - FCERI:IgE [plasma membrane] (Bos taurus)
        
        IgE [extracellular region] (Bos taurus)
        
        IgE Heavy Chain [extracellular region] (Bos taurus)
        
        IGHE [extracellular region] (Bos taurus)
      - FCERI:IgE:Allergen aggregate [plasma membrane] (Bos taurus)
        
        FCERI:IgE aggregate [plasma membrane] (Bos taurus)
        
        FCERI:IgE [plasma membrane] (Bos taurus)
        
        IgE [extracellular region] (Bos taurus)
        
        IgE Heavy Chain [extracellular region] (Bos taurus)
        
        IGHE [extracellular region] (Bos taurus)
    - FCERI mediated Ca+2 mobilization (Bos taurus)
      - Phosphorylation of TEC kinases by p-SYK (Bos taurus)
        
        Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Bos taurus)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Bos taurus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Bos taurus)
        
        IgE [extracellular region] (Bos taurus)
        
        IgE Heavy Chain [extracellular region] (Bos taurus)
        
        IGHE [extracellular region] (Bos taurus)
    - FCERI mediated MAPK activation (Bos taurus)
      - Phosphorylation of SHC by SYK kinase (Bos taurus)
        
        Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Bos taurus)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Bos taurus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Bos taurus)
        
        IgE [extracellular region] (Bos taurus)
        
        IgE Heavy Chain [extracellular region] (Bos taurus)
        
        IGHE [extracellular region] (Bos taurus)
      - Phosphorylation of SLP-76 by p-SYK (Bos taurus)
        
        Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Bos taurus)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Bos taurus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Bos taurus)
        
        IgE [extracellular region] (Bos taurus)
        
        IgE Heavy Chain [extracellular region] (Bos taurus)
        
        IGHE [extracellular region] (Bos taurus)
    - FCERI mediated NF-kB activation (Bos taurus)
      - Phosphorylation of PKC-theta (Bos taurus)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Bos taurus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Bos taurus)
        
        IgE [extracellular region] (Bos taurus)
        
        IgE Heavy Chain [extracellular region] (Bos taurus)
        
        IGHE [extracellular region] (Bos taurus)
    - IgE binds FCERI (Bos taurus)
      - FCERI:IgE [plasma membrane] (Bos taurus)
        
        IgE [extracellular region] (Bos taurus)
        
        IgE Heavy Chain [extracellular region] (Bos taurus)
        
        IGHE [extracellular region] (Bos taurus)
      - IgE [extracellular region] (Bos taurus)
        
        IgE Heavy Chain [extracellular region] (Bos taurus)
        
        IGHE [extracellular region] (Bos taurus)
    - IgE binds omalizumab (Bos taurus)
      - IgE [extracellular region] (Bos taurus)
        
        IgE Heavy Chain [extracellular region] (Bos taurus)
        
        IGHE [extracellular region] (Bos taurus)
      - IgE:omalizumab [extracellular region] (Bos taurus)
        
        IgE [extracellular region] (Bos taurus)
        
        IgE Heavy Chain [extracellular region] (Bos taurus)
        
        IGHE [extracellular region] (Bos taurus)
    - Phosphorylation of LAT by p-SYK (Bos taurus)
      - Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Bos taurus)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Bos taurus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Bos taurus)
        
        IgE [extracellular region] (Bos taurus)
        
        IgE Heavy Chain [extracellular region] (Bos taurus)
        
        IGHE [extracellular region] (Bos taurus)
    - Phosphorylation of beta and gamma subunits by LYN (Bos taurus)
      - Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Bos taurus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Bos taurus)
        
        IgE [extracellular region] (Bos taurus)
        
        IgE Heavy Chain [extracellular region] (Bos taurus)
        
        IGHE [extracellular region] (Bos taurus)
      - FCERI:IgE:Allergen aggregate [plasma membrane] (Bos taurus)
        
        FCERI:IgE aggregate [plasma membrane] (Bos taurus)
        
        FCERI:IgE [plasma membrane] (Bos taurus)
        
        IgE [extracellular region] (Bos taurus)
        
        IgE Heavy Chain [extracellular region] (Bos taurus)
        
        IGHE [extracellular region] (Bos taurus)
    - Recruitment of SYK to p-FCERI gamma subunit (Bos taurus)
      - Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Bos taurus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Bos taurus)
        
        IgE [extracellular region] (Bos taurus)
        
        IgE Heavy Chain [extracellular region] (Bos taurus)
        
        IGHE [extracellular region] (Bos taurus)
      - Clustered p:LYN:p-FCERI:IgE:allergen:SYK [plasma membrane] (Bos taurus)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Bos taurus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Bos taurus)
        
        IgE [extracellular region] (Bos taurus)
        
        IgE Heavy Chain [extracellular region] (Bos taurus)
        
        IGHE [extracellular region] (Bos taurus)
    - Role of LAT2/NTAL/LAB on calcium mobilization (Bos taurus)
      - Phosphorylation of NTAL by p-SYK/Lyn (Bos taurus)
        
        Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Bos taurus)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Bos taurus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Bos taurus)
        
        IgE [extracellular region] (Bos taurus)
        
        IgE Heavy Chain [extracellular region] (Bos taurus)
        
        IGHE [extracellular region] (Bos taurus)

External Reference Information

External Reference

UniProt:G3N342

Reference Genes

ENSEMBL:ENSBTAG00000047632.2

Other Identifiers

GO:0002376

GO:0003823

GO:0005576

GO:0005615

GO:0006958

GO:0019731

GO:0034987

GO:0042571

GO:0098542

Participates

as a component of

IgE Heavy Chain [extracellular region] (Bos taurus)

Inferred From

IGHE [extracellular region] (Homo sapiens)

Cross References

Ensembl

ENSBTAT00000065204, ENSBTAP00000056315, ENSBTAG00000047632

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