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LOC780968 [nucleoplasm]
Stable Identifier
R-BTA-1234142
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
nucleoplasm
Synonyms
RBX1, A0A3Q1LNF8
Locations in the PathwayBrowser
Expand all
Cell Cycle (Bos taurus)
Cell Cycle, Mitotic (Bos taurus)
S Phase (Bos taurus)
Synthesis of DNA (Bos taurus)
Switching of origins to a post-replicative state (Bos taurus)
Orc1 removal from chromatin (Bos taurus)
Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Bos taurus)
SCF (SKP2) complex [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
Cellular responses to stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
Cellular response to chemical stress (Bos taurus)
KEAP1-NFE2L2 pathway (Bos taurus)
Nuclear events mediated by NFE2L2 (Bos taurus)
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Bos taurus)
BTRC binds p-S344, 347 NFE2L2 (Bos taurus)
BTRC:SKP1:CUL1:RBX1:p-S344, S347 NFE2L2 [nucleoplasm] (Bos taurus)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Bos taurus)
BTRC:SKP1:CUL1:RBX1:p-S344, S347 NFE2L2 [nucleoplasm] (Bos taurus)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
BTRC:SKP1:CUL1:RBX1:ub,p-S335, S338 NFE2L2 [nucleoplasm] (Bos taurus)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
Ub,pS335,S338,T NFE2L2 is degraded (Bos taurus)
BTRC:SKP1:CUL1:RBX1:ub,p-S335, S338 NFE2L2 [nucleoplasm] (Bos taurus)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
Regulation of BACH1 activity (Bos taurus)
BACH1:FBXL17 binds SCF(SKP2) complex (Bos taurus)
BACH1:FBXL17:SCF (SKP2) [nucleoplasm] (Bos taurus)
SCF (SKP2) complex [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
SCF (SKP2) complex [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Bos taurus)
BACH1:FBXL17:SCF (SKP2) [nucleoplasm] (Bos taurus)
SCF (SKP2) complex [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
SCF (SKP2) complex [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
Cellular response to hypoxia (Bos taurus)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Bos taurus)
Nuclear VBC complex ubiquitinylates HIF-alpha (Bos taurus)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Bos taurus)
VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
ub-HIF-alpha:VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Bos taurus)
VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Bos taurus)
VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Bos taurus)
VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Bos taurus)
ub-HIF-alpha:VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Bos taurus)
VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
DNA Repair (Bos taurus)
DNA Damage Bypass (Bos taurus)
Recognition of DNA damage by PCNA-containing replication complex (Bos taurus)
RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Bos taurus)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL [nucleoplasm] (Bos taurus)
RBX1:CUL4:DDB1:DTL [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Bos taurus)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL [nucleoplasm] (Bos taurus)
RBX1:CUL4:DDB1:DTL [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Bos taurus)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL [nucleoplasm] (Bos taurus)
RBX1:CUL4:DDB1:DTL [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Bos taurus)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL [nucleoplasm] (Bos taurus)
RBX1:CUL4:DDB1:DTL [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
Nucleotide Excision Repair (Bos taurus)
Global Genome Nucleotide Excision Repair (GG-NER) (Bos taurus)
DNA Damage Recognition in GG-NER (Bos taurus)
PARP1 or PARP2 PARylates DDB2 and autoPARylates (Bos taurus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Bos taurus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Bos taurus)
PAR-UV-DDB [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB:PARP1,PARP2 [nucleoplasm] (Bos taurus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Bos taurus)
UV-DDB [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
PARP1 or PARP2 binds DDB2 at GG-NER site (Bos taurus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Bos taurus)
UV-DDB [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB:PARP1,PARP2 [nucleoplasm] (Bos taurus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Bos taurus)
UV-DDB [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
UV-DDB ubiquitinates XPC (Bos taurus)
UV-DDB [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Bos taurus)
UV-DDB [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Bos taurus)
UV-DDB [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Bos taurus)
UV-DDB:COP9 Signalosome [nucleoplasm] (Bos taurus)
UV-DDB [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Bos taurus)
UV-DDB [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
Dual Incision in GG-NER (Bos taurus)
3'-incision of DNA by ERCC5 (XPG) in GG-NER (Bos taurus)
GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Bos taurus)
PAR-UV-DDB [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
PAR-UV-DDB [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Bos taurus)
GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Bos taurus)
PAR-UV-DDB [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Bos taurus)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Bos taurus)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Bos taurus)
PAR-UV-DDB [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
DNA polymerases delta, epsilon or kappa bind the GG-NER site (Bos taurus)
GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Bos taurus)
PAR-UV-DDB [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Bos taurus)
PAR-UV-DDB [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
Formation of Incision Complex in GG-NER (Bos taurus)
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Bos taurus)
GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Bos taurus)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Bos taurus)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Bos taurus)
PAR-UV-DDB [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Bos taurus)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Bos taurus)
PAR-UV-DDB [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
CHD1L is recruited to GG-NER site (Bos taurus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Bos taurus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Bos taurus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Bos taurus)
PAR-UV-DDB [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Bos taurus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Bos taurus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Bos taurus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Bos taurus)
PAR-UV-DDB [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Bos taurus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Bos taurus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Bos taurus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Bos taurus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Bos taurus)
PAR-UV-DDB [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Bos taurus)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB [nucleoplasm] (Bos taurus)
PAR-UV-DDB [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
Formation of the pre-incision complex in GG-NER (Bos taurus)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Bos taurus)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Bos taurus)
PAR-UV-DDB [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Bos taurus)
PAR-UV-DDB [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
RNF111 ubiquitinates SUMOylated XPC (Bos taurus)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Bos taurus)
PAR-UV-DDB [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Bos taurus)
PAR-UV-DDB [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
Recruitment of XPA and release of CAK (Bos taurus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Bos taurus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Bos taurus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Bos taurus)
PAR-UV-DDB [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Bos taurus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Bos taurus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Bos taurus)
PAR-UV-DDB [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
SUMOylation of XPC (Bos taurus)
Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Bos taurus)
PAR-UV-DDB [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Bos taurus)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB [nucleoplasm] (Bos taurus)
PAR-UV-DDB [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
TFIIH binds GG-NER site to form a verification complex (Bos taurus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Bos taurus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Bos taurus)
PAR-UV-DDB [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Bos taurus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Bos taurus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Bos taurus)
PAR-UV-DDB [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Bos taurus)
Dual incision in TC-NER (Bos taurus)
3' incision by ERCC5 (XPG) in TC-NER (Bos taurus)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Bos taurus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Bos taurus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Bos taurus)
TC-NER incision complex [nucleoplasm] (Bos taurus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Bos taurus)
TC-NER incision complex [nucleoplasm] (Bos taurus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
DNA polymerases delta, epsilon or kappa bind the TC-NER site (Bos taurus)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Bos taurus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
ERCC2-facilitated RNA Pol II backtracking in TC-NER (Bos taurus)
TC-NER pre-incision complex [nucleoplasm] (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
ERCC3-facilitated RNA Pol II backtracking in TC-NER (Bos taurus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
ERCC5 and RPA bind TC-NER site (Bos taurus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
Formation of TC-NER Pre-Incision Complex (Bos taurus)
Assembly of the pre-incision complex in TC-NER (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
ERCC8 (CSA) binds stalled RNA Pol II (Bos taurus)
ERCC8:DDB1:CUL4:RBX1:COP9 Signalosome [nucleoplasm] (Bos taurus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Bos taurus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
UVSSA:USP7 deubiquitinates ERCC6 (Bos taurus)
TC-NER pre-incision complex [nucleoplasm] (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
Gap-filling DNA repair synthesis and ligation in TC-NER (Bos taurus)
Ligation of newly synthesized repair patch to incised DNA in TC-NER (Bos taurus)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Bos taurus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Bos taurus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Bos taurus)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Bos taurus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Bos taurus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
DNA Replication (Bos taurus)
Synthesis of DNA (Bos taurus)
Switching of origins to a post-replicative state (Bos taurus)
Orc1 removal from chromatin (Bos taurus)
Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Bos taurus)
SCF (SKP2) complex [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
Gene expression (Transcription) (Bos taurus)
RNA Polymerase II Transcription (Bos taurus)
Generic Transcription Pathway (Bos taurus)
Transcriptional regulation by RUNX2 (Bos taurus)
Regulation of RUNX2 expression and activity (Bos taurus)
SCF(SKP2) complex binds RUNX2 (Bos taurus)
RUNX2:SCF(SKP2) [nucleoplasm] (Bos taurus)
SCF (SKP2) complex [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
SCF (SKP2) complex [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
SCF(SKP2) polyubiquitinates RUNX2 (Bos taurus)
RUNX2:SCF(SKP2) [nucleoplasm] (Bos taurus)
SCF (SKP2) complex [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
SCF (SKP2) complex [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
Neddylation (Bos taurus)
AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
NEDD8-AcM-UBE2M:CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUND1,2,4,5 [nucleoplasm] (Bos taurus)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Bos taurus)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
NEDD8-CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Bos taurus)
NEDD8-CRL4 E3 ligase complex [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Bos taurus)
CRL4 E3 ubiquitin ligase:CAND1 [nucleoplasm] (Bos taurus)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Bos taurus)
CRL4 E3 ubiquitin ligase:CAND1 [nucleoplasm] (Bos taurus)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Bos taurus)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Bos taurus)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Bos taurus)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
NEDD8-CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Bos taurus)
NEDD8-CRL4 E3 ligase complex [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Bos taurus)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Bos taurus)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
NEDD8-AcM-UBE2M:CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUND1,2,4,5 [nucleoplasm] (Bos taurus)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Bos taurus)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
Signal Transduction (Bos taurus)
Signaling by Hedgehog (Bos taurus)
Hedgehog 'on' state (Bos taurus)
GLI2,3 are degraded by the proteasome (Bos taurus)
SPOP:CUL3:RBX1 [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
ub-2p-GLI2,3:SPOP:CUL3:RBX1 [nucleoplasm] (Bos taurus)
SPOP:CUL3:RBX1 [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Bos taurus)
2p-GLI:SPOP:CUL3:RBX1 [nucleoplasm] (Bos taurus)
SPOP:CUL3:RBX1 [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
ub-2p-GLI2,3:SPOP:CUL3:RBX1 [nucleoplasm] (Bos taurus)
SPOP:CUL3:RBX1 [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Bos taurus)
2p-GLI:SPOP:CUL3:RBX1 [nucleoplasm] (Bos taurus)
SPOP:CUL3:RBX1 [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
SPOP:CUL3:RBX1 [nucleoplasm] (Bos taurus)
LOC780968 [nucleoplasm] (Bos taurus)
External Reference Information
External Reference
UniProt:A0A3Q1LNF8
Gene Names
LOC780968
Reference Genes
ENSEMBL:ENSBTAG00000052566.1
Participates
as a component of
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Bos taurus)
NEDD8-CRL4 E3 ligase complex [nucleoplasm] (Bos taurus)
RBX1:CUL4:DDB1:DTL [nucleoplasm] (Bos taurus)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Bos taurus)
SPOP:CUL3:RBX1 [nucleoplasm] (Bos taurus)
UV-DDB [nucleoplasm] (Bos taurus)
PAR-UV-DDB [nucleoplasm] (Bos taurus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Bos taurus)
SCF (SKP2) complex [nucleoplasm] (Bos taurus)
Other forms of this molecule
LOC780968 [cytosol]
Inferred From
RBX1 [nucleoplasm]
(Homo sapiens)
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