Reactome | PF4(48-101) [extracellular region]

PF4(48-101) [extracellular region]

Stable Identifier

R-BTA-114629

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

extracellular region

Synonyms

F1MD83

Locations in the PathwayBrowser

Expand all

Signal Transduction (Bos taurus)

- Signaling by GPCR (Bos taurus)
  - GPCR downstream signalling (Bos taurus)
    - G alpha (i) signalling events (Bos taurus)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Bos taurus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Bos taurus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Bos taurus)
        
        CXCR2 ligands [extracellular region] (Bos taurus)
        
        CXCL4 homotetramer [extracellular region] (Bos taurus)
        
        PF4(48-101) [extracellular region] (Bos taurus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Bos taurus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Bos taurus)
        
        CXCR2 ligands [extracellular region] (Bos taurus)
        
        CXCL4 homotetramer [extracellular region] (Bos taurus)
        
        PF4(48-101) [extracellular region] (Bos taurus)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Bos taurus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Bos taurus)
        
        CXCR2 ligands [extracellular region] (Bos taurus)
        
        CXCL4 homotetramer [extracellular region] (Bos taurus)
        
        PF4(48-101) [extracellular region] (Bos taurus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Bos taurus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Bos taurus)
        
        CXCR2 ligands [extracellular region] (Bos taurus)
        
        CXCL4 homotetramer [extracellular region] (Bos taurus)
        
        PF4(48-101) [extracellular region] (Bos taurus)
      - The Ligand:GPCR:Gi complex dissociates (Bos taurus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Bos taurus)
        
        CXCR2 ligands [extracellular region] (Bos taurus)
        
        CXCL4 homotetramer [extracellular region] (Bos taurus)
        
        PF4(48-101) [extracellular region] (Bos taurus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Bos taurus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Bos taurus)
        
        CXCR2 ligands [extracellular region] (Bos taurus)
        
        CXCL4 homotetramer [extracellular region] (Bos taurus)
        
        PF4(48-101) [extracellular region] (Bos taurus)
  - GPCR ligand binding (Bos taurus)
    - Class A/1 (Rhodopsin-like receptors) (Bos taurus)
      - Peptide ligand-binding receptors (Bos taurus)
        
        Chemokine receptors bind chemokines (Bos taurus)
        
        Receptor CXCR2 binds ligands CXCL1 to 7 (Bos taurus)
        
        CXCR2 ligands [extracellular region] (Bos taurus)
        
        CXCL4 homotetramer [extracellular region] (Bos taurus)
        
        PF4(48-101) [extracellular region] (Bos taurus)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Bos taurus)
        
        CXCR2 ligands [extracellular region] (Bos taurus)
        
        CXCL4 homotetramer [extracellular region] (Bos taurus)
        
        PF4(48-101) [extracellular region] (Bos taurus)

External Reference Information

External Reference

UniProt:F1MD83

Reference Genes

ENSEMBL:ENSBTAG00000011961.6

UCSC:F1MD83

Other Identifiers

Bt.11581.1.S1_at

GO:0002376

GO:0005125

GO:0005576

GO:0005615

GO:0006935

GO:0006952

GO:0006954

GO:0006955

GO:0007165

GO:0008009

GO:0008201

GO:0016020

GO:0030593

GO:0045236

GO:0048018

GO:0048870

GO:0060326

GO:0061844

GO:0071222

GO:0098542

GO:0098772

Participates

as a member of

Platelet alpha granule contents [extracellular region] (Bos taurus)

as a component of

CXCL4 homotetramer [extracellular region] (Bos taurus)

Other forms of this molecule

PF4V1(31-104) [extracellular region]

PF4(32-101) [extracellular region]

PF4(32-101) [platelet alpha granule lumen]

PF4(48-101) [platelet alpha granule lumen]

Inferred From

PF4(48-101) [extracellular region] (Homo sapiens)

Cross References

ENSEMBL

ENSBTAT00000015874, ENSBTAP00000015874, ENSBTAG00000011961