Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
CDK4 [nucleoplasm]
Stable Identifier
R-BTA-113843
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
nucleoplasm
Synonyms
CDK4, Q32KY4
Locations in the PathwayBrowser
Expand all
Cell Cycle (Bos taurus)
Cell Cycle, Mitotic (Bos taurus)
Mitotic G1 phase and G1/S transition (Bos taurus)
G1 Phase (Bos taurus)
Cyclin D associated events in G1 (Bos taurus)
CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Bos taurus)
CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); CDK4,CDK6:CCND; (CDK4,CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Bos taurus)
CDK4,CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Bos taurus)
CDK4/6:CCND [nucleoplasm] (Bos taurus)
CDK4,CDK6 [nucleoplasm] (Bos taurus)
CDK4 [nucleoplasm] (Bos taurus)
CDK4:CCND [nucleoplasm] (Bos taurus)
CDK4:CCND1 [nucleoplasm] (Bos taurus)
CDK4 [nucleoplasm] (Bos taurus)
Cyclin D2:Cdk4 [nucleoplasm] (Bos taurus)
CDK4 [nucleoplasm] (Bos taurus)
Cyclin D3:Cdk4 [nucleoplasm] (Bos taurus)
CDK4 [nucleoplasm] (Bos taurus)
Cyclin D:CDK4,CDK6:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Bos taurus)
CDK4,CDK6 [nucleoplasm] (Bos taurus)
CDK4 [nucleoplasm] (Bos taurus)
Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Bos taurus)
CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); CDK4,CDK6:CCND; (CDK4,CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Bos taurus)
CDK4,CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Bos taurus)
CDK4/6:CCND [nucleoplasm] (Bos taurus)
CDK4,CDK6 [nucleoplasm] (Bos taurus)
CDK4 [nucleoplasm] (Bos taurus)
CDK4:CCND [nucleoplasm] (Bos taurus)
CDK4:CCND1 [nucleoplasm] (Bos taurus)
CDK4 [nucleoplasm] (Bos taurus)
Cyclin D2:Cdk4 [nucleoplasm] (Bos taurus)
CDK4 [nucleoplasm] (Bos taurus)
Cyclin D3:Cdk4 [nucleoplasm] (Bos taurus)
CDK4 [nucleoplasm] (Bos taurus)
Cyclin D:CDK4,CDK6:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Bos taurus)
CDK4,CDK6 [nucleoplasm] (Bos taurus)
CDK4 [nucleoplasm] (Bos taurus)
S Phase (Bos taurus)
Ubiquitin-dependent degradation of Cyclin D (Bos taurus)
Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Bos taurus)
phospho(T286)-Cyclin D1:Cdk4 [nucleoplasm] (Bos taurus)
CDK4 [nucleoplasm] (Bos taurus)
Chromatin organization (Bos taurus)
Chromatin modifying enzymes (Bos taurus)
RMTs methylate histone arginines (Bos taurus)
CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) (Bos taurus)
CCND1:CDK4:PRMT5:pT5-WDR77 [nucleoplasm] (Bos taurus)
CDK4 [nucleoplasm] (Bos taurus)
CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 (Bos taurus)
CCND1:CDK4:PRMT5:pT5-WDR77 [nucleoplasm] (Bos taurus)
CDK4 [nucleoplasm] (Bos taurus)
CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Bos taurus)
CCND1:CDK4:PRMT5:WDR77 [nucleoplasm] (Bos taurus)
CDK4 [nucleoplasm] (Bos taurus)
CCND1:CDK4:PRMT5:pT5-WDR77 [nucleoplasm] (Bos taurus)
CDK4 [nucleoplasm] (Bos taurus)
CDK4 [nucleoplasm] (Bos taurus)
COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77 (Bos taurus)
CCND1:CDK4:PRMT5:pT5-WDR77 [nucleoplasm] (Bos taurus)
CDK4 [nucleoplasm] (Bos taurus)
CCND1:CDK4:PRMT5:pT5-WDR77:COPRS [nucleoplasm] (Bos taurus)
CCND1:CDK4:PRMT5:pT5-WDR77 [nucleoplasm] (Bos taurus)
CDK4 [nucleoplasm] (Bos taurus)
COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) (Bos taurus)
CCND1:CDK4:PRMT5:pT5-WDR77:COPRS [nucleoplasm] (Bos taurus)
CCND1:CDK4:PRMT5:pT5-WDR77 [nucleoplasm] (Bos taurus)
CDK4 [nucleoplasm] (Bos taurus)
PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) (Bos taurus)
CCND1:CDK4:PRMT5:pT5-WDR77:COPRS [nucleoplasm] (Bos taurus)
CCND1:CDK4:PRMT5:pT5-WDR77 [nucleoplasm] (Bos taurus)
CDK4 [nucleoplasm] (Bos taurus)
Gene expression (Transcription) (Bos taurus)
RNA Polymerase II Transcription (Bos taurus)
Generic Transcription Pathway (Bos taurus)
Transcriptional regulation by RUNX2 (Bos taurus)
CDK4 phosphorylates RUNX2 (Bos taurus)
CDK4 [nucleoplasm] (Bos taurus)
CDK4:CCND1 [nucleoplasm] (Bos taurus)
CDK4 [nucleoplasm] (Bos taurus)
External Reference Information
External Reference
UniProt:Q32KY4
Gene Names
CDK4
Reference Genes
BioGPS Gene:510618 CDK4
ENSEMBL:ENSBTAG00000007160
KEGG:bta:510618 CDK4
Monarch:510618 CDK4
NCBI Gene:510618 CDK4
UCSC:Q32KY4 CDK4
Reference Transcript
RefSeq:NM_001037594.2 CDK4
RefSeq:XM_005206553.5 CDK4
Other Identifiers
510618
Bt.4661.1.S1_at
GO:0003824
GO:0004672
GO:0005524
GO:0006468
GO:0016740
GO:0140096
Participates
as a component of
CCND1:CDK4:PRMT5:WDR77 [nucleoplasm] (Bos taurus)
CCND1:CDK4:PRMT5:pT5-WDR77 [nucleoplasm] (Bos taurus)
phospho(T286)-Cyclin D1:Cdk4 [nucleoplasm] (Bos taurus)
Cyclin D3:Cdk4 [nucleoplasm] (Bos taurus)
Cyclin D2:Cdk4 [nucleoplasm] (Bos taurus)
CDK4:CCND1 [nucleoplasm] (Bos taurus)
as a member of
CDK4,CDK6 [nucleoplasm] (Bos taurus)
Other forms of this molecule
CDK4 [cytosol]
phospho-CDK4 [nucleoplasm]
Inferred From
CDK4 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
XP_005206610.1
,
NP_001032683.1
ENSEMBL
ENSBTAT00000009420
,
ENSBTAG00000007160
,
ENSBTAP00000009420
IntEnz
2.7.11.22
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text