Reactome | CCND2 [nucleoplasm]

CCND2 [nucleoplasm]

Stable Identifier

R-BTA-113827

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

nucleoplasm

Synonyms

CCND2, Q0P5D3

Locations in the PathwayBrowser

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Cell Cycle (Bos taurus)

- Cell Cycle, Mitotic (Bos taurus)
  - Mitotic G1 phase and G1/S transition (Bos taurus)
    - G1 Phase (Bos taurus)
      - Cyclin D associated events in G1 (Bos taurus)
        
        CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Bos taurus)
        
        CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); CDK4,CDK6:CCND; (CDK4,CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Bos taurus)
        
        CDK4,CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Bos taurus)
        
        CDK4/6:CCND [nucleoplasm] (Bos taurus)
        
        Cyclin D [nucleoplasm] (Bos taurus)
        
        CCND2 [nucleoplasm] (Bos taurus)
        
        CDK4:CCND [nucleoplasm] (Bos taurus)
        
        Cyclin D2:Cdk4 [nucleoplasm] (Bos taurus)
        
        CCND2 [nucleoplasm] (Bos taurus)
        
        CDK6:CCND [nucleoplasm] (Bos taurus)
        
        Cyclin D2:Cdk6 [nucleoplasm] (Bos taurus)
        
        CCND2 [nucleoplasm] (Bos taurus)
        
        Cyclin D:CDK4,CDK6:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Bos taurus)
        
        Cyclin D [nucleoplasm] (Bos taurus)
        
        CCND2 [nucleoplasm] (Bos taurus)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Bos taurus)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Bos taurus)
        
        p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Bos taurus)
        
        Cyclin D [nucleoplasm] (Bos taurus)
        
        CCND2 [nucleoplasm] (Bos taurus)
        
        p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Bos taurus)
        
        p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Bos taurus)
        
        Cyclin D [nucleoplasm] (Bos taurus)
        
        CCND2 [nucleoplasm] (Bos taurus)
        
        p-T172-CDK4:CCND [nucleoplasm] (Bos taurus)
        
        p-T172-CDK4:CCND2 [nucleoplasm] (Bos taurus)
        
        CCND2 [nucleoplasm] (Bos taurus)
        
        p-T177-CDK6:CCND [nucleoplasm] (Bos taurus)
        
        p-T177-CDK6:CCND2 [nucleoplasm] (Bos taurus)
        
        CCND2 [nucleoplasm] (Bos taurus)
        
        Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Bos taurus)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Bos taurus)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Bos taurus)
        
        p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Bos taurus)
        
        Cyclin D [nucleoplasm] (Bos taurus)
        
        CCND2 [nucleoplasm] (Bos taurus)
        
        p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Bos taurus)
        
        p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Bos taurus)
        
        Cyclin D [nucleoplasm] (Bos taurus)
        
        CCND2 [nucleoplasm] (Bos taurus)
        
        p-T172-CDK4:CCND [nucleoplasm] (Bos taurus)
        
        p-T172-CDK4:CCND2 [nucleoplasm] (Bos taurus)
        
        CCND2 [nucleoplasm] (Bos taurus)
        
        p-T177-CDK6:CCND [nucleoplasm] (Bos taurus)
        
        p-T177-CDK6:CCND2 [nucleoplasm] (Bos taurus)
        
        CCND2 [nucleoplasm] (Bos taurus)
        
        Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Bos taurus)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Bos taurus)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Bos taurus)
        
        p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Bos taurus)
        
        Cyclin D [nucleoplasm] (Bos taurus)
        
        CCND2 [nucleoplasm] (Bos taurus)
        
        p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Bos taurus)
        
        p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Bos taurus)
        
        Cyclin D [nucleoplasm] (Bos taurus)
        
        CCND2 [nucleoplasm] (Bos taurus)
        
        p-T172-CDK4:CCND [nucleoplasm] (Bos taurus)
        
        p-T172-CDK4:CCND2 [nucleoplasm] (Bos taurus)
        
        CCND2 [nucleoplasm] (Bos taurus)
        
        p-T177-CDK6:CCND [nucleoplasm] (Bos taurus)
        
        p-T177-CDK6:CCND2 [nucleoplasm] (Bos taurus)
        
        CCND2 [nucleoplasm] (Bos taurus)
        
        p-T172-CDK4:CCND:CDK4 inhibitors [nucleoplasm] (Bos taurus)
        
        p-T172-CDK4:CCND2:CDK4 inhibitors (CCND2) [nucleoplasm] (Bos taurus)
        
        p-T172-CDK4:CCND2 [nucleoplasm] (Bos taurus)
        
        CCND2 [nucleoplasm] (Bos taurus)
        
        p-T177-CDK6:CCND:CDK6 inhibitors [nucleoplasm] (Bos taurus)
        
        p-T177-CDK6:CCND2:CDK6 inhibitors (CCND2) [nucleoplasm] (Bos taurus)
        
        p-T177-CDK6:CCND2 [nucleoplasm] (Bos taurus)
        
        CCND2 [nucleoplasm] (Bos taurus)
        
        Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Bos taurus)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Bos taurus)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Bos taurus)
        
        p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Bos taurus)
        
        Cyclin D [nucleoplasm] (Bos taurus)
        
        CCND2 [nucleoplasm] (Bos taurus)
        
        p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Bos taurus)
        
        p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Bos taurus)
        
        Cyclin D [nucleoplasm] (Bos taurus)
        
        CCND2 [nucleoplasm] (Bos taurus)
        
        p-T172-CDK4:CCND [nucleoplasm] (Bos taurus)
        
        p-T172-CDK4:CCND2 [nucleoplasm] (Bos taurus)
        
        CCND2 [nucleoplasm] (Bos taurus)
        
        p-T177-CDK6:CCND [nucleoplasm] (Bos taurus)
        
        p-T177-CDK6:CCND2 [nucleoplasm] (Bos taurus)
        
        CCND2 [nucleoplasm] (Bos taurus)
        
        Drug-mediated inhibition of CDK4/CDK6 activity (Bos taurus)
        
        CDK4 inhibitors bind CDK4 (Bos taurus)
        
        p-T172-CDK4:CCND [nucleoplasm] (Bos taurus)
        
        p-T172-CDK4:CCND2 [nucleoplasm] (Bos taurus)
        
        CCND2 [nucleoplasm] (Bos taurus)
        
        p-T172-CDK4:CCND:CDK4 inhibitors [nucleoplasm] (Bos taurus)
        
        p-T172-CDK4:CCND2:CDK4 inhibitors (CCND2) [nucleoplasm] (Bos taurus)
        
        p-T172-CDK4:CCND2 [nucleoplasm] (Bos taurus)
        
        CCND2 [nucleoplasm] (Bos taurus)
        
        CDK6 inhibitors bind CDK6 (Bos taurus)
        
        p-T177-CDK6:CCND [nucleoplasm] (Bos taurus)
        
        p-T177-CDK6:CCND2 [nucleoplasm] (Bos taurus)
        
        CCND2 [nucleoplasm] (Bos taurus)
        
        p-T177-CDK6:CCND:CDK6 inhibitors [nucleoplasm] (Bos taurus)
        
        p-T177-CDK6:CCND2:CDK6 inhibitors (CCND2) [nucleoplasm] (Bos taurus)
        
        p-T177-CDK6:CCND2 [nucleoplasm] (Bos taurus)
        
        CCND2 [nucleoplasm] (Bos taurus)
        
        RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Bos taurus)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Bos taurus)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Bos taurus)
        
        p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Bos taurus)
        
        Cyclin D [nucleoplasm] (Bos taurus)
        
        CCND2 [nucleoplasm] (Bos taurus)
        
        p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Bos taurus)
        
        p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Bos taurus)
        
        Cyclin D [nucleoplasm] (Bos taurus)
        
        CCND2 [nucleoplasm] (Bos taurus)
        
        p-T172-CDK4:CCND [nucleoplasm] (Bos taurus)
        
        p-T172-CDK4:CCND2 [nucleoplasm] (Bos taurus)
        
        CCND2 [nucleoplasm] (Bos taurus)
        
        p-T177-CDK6:CCND [nucleoplasm] (Bos taurus)
        
        p-T177-CDK6:CCND2 [nucleoplasm] (Bos taurus)
        
        CCND2 [nucleoplasm] (Bos taurus)
        
        Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Bos taurus)
        
        CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); CDK4,CDK6:CCND; (CDK4,CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Bos taurus)
        
        CDK4,CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Bos taurus)
        
        CDK4/6:CCND [nucleoplasm] (Bos taurus)
        
        Cyclin D [nucleoplasm] (Bos taurus)
        
        CCND2 [nucleoplasm] (Bos taurus)
        
        CDK4:CCND [nucleoplasm] (Bos taurus)
        
        Cyclin D2:Cdk4 [nucleoplasm] (Bos taurus)
        
        CCND2 [nucleoplasm] (Bos taurus)
        
        CDK6:CCND [nucleoplasm] (Bos taurus)
        
        Cyclin D2:Cdk6 [nucleoplasm] (Bos taurus)
        
        CCND2 [nucleoplasm] (Bos taurus)
        
        Cyclin D:CDK4,CDK6:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Bos taurus)
        
        Cyclin D [nucleoplasm] (Bos taurus)
        
        CCND2 [nucleoplasm] (Bos taurus)

External Reference Information

External Reference

UniProt:Q0P5D3

Gene Names

CCND2

Reference Genes

BioGPS Gene:615414 CCND2

ENSEMBL:ENSBTAG00000016649

KEGG:bta:615414 CCND2

Monarch:615414 CCND2

NCBI Gene:615414 CCND2

UCSC:Q0P5D3 CCND2

Reference Transcript

RefSeq:NM_001076372.1 CCND2

Other Identifiers

615414

Bt.4895.1.S1_at

GO:0000082

GO:0000307

GO:0000785

GO:0005634

GO:0005654

GO:0005730

GO:0005829

GO:0007616

GO:0008284

GO:0008344

GO:0019901

GO:0031965

GO:0043066

GO:0043539

GO:0050877

GO:0051726

GO:0061575

GO:0071481

GO:0097129

GO:0098772

GO:1900087

Participates

as a candidate of

as a component of

Other forms of this molecule

CCND2 [cytosol]

Inferred From

CCND2 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001069840.1

ENSEMBL

ENSBTAP00000022145, ENSBTAG00000016649, ENSBTAT00000022145

VGNC

26963

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