Reactome | phospho-SH2B2 [cytosol]

phospho-SH2B2 [cytosol]

Stable Identifier

R-BTA-112184

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

p-Y629-SH2B2, F1MRH8

Locations in the PathwayBrowser

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Signal Transduction (Bos taurus)

- Signaling by Receptor Tyrosine Kinases (Bos taurus)
  - Signaling by SCF-KIT (Bos taurus)
    - Regulation of KIT signaling (Bos taurus)
      - Phosphorylation of APS (Bos taurus)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Bos taurus)
        
        p-APS dimer [cytosol] (Bos taurus)
        
        phospho-SH2B2 [cytosol] (Bos taurus)
      - Recruitment of CBL to KIT (Bos taurus)
        
        CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] (Bos taurus)
        
        Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Bos taurus)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Bos taurus)
        
        p-APS dimer [cytosol] (Bos taurus)
        
        phospho-SH2B2 [cytosol] (Bos taurus)
        
        Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Bos taurus)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Bos taurus)
        
        p-APS dimer [cytosol] (Bos taurus)
        
        phospho-SH2B2 [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:F1MRH8

Gene Names

SH2B2

Reference Genes

ENSEMBL:ENSBTAG00000009691.5

Other Identifiers

617840

GO:0002376

GO:0005068

GO:0005886

GO:0007165

GO:0007169

GO:0023052

GO:0035556

GO:0035591

GO:0050851

GO:0060090

Participates

as a component of

p-APS dimer [cytosol] (Bos taurus)

Other forms of this molecule

SH2B2 [cytosol]

Inferred From

p-Y629-SH2B2 [cytosol] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 629 (in Homo sapiens)

Coordinate

629

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

OpenTargets

ENSG00000160999

Ensembl

ENSBTAP00000012781, ENSBTAT00000012781, ENSBTAG00000009691

VGNC

59364

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