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IL6:IL6R [plasma membrane]
Stable Identifier
R-BTA-1067638
Type
Complex
Species
Bos taurus
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Immune System (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
Signaling by Interleukins (Bos taurus)
Interleukin-6 family signaling (Bos taurus)
Interleukin-6 signaling (Bos taurus)
Assembly of hexameric IL-6 receptor (Bos taurus)
IL6 receptor hexamer:JAKs [plasma membrane] (Bos taurus)
IL6 receptor trimer:JAKs [plasma membrane] (Bos taurus)
IL6:IL6RA:IL6RB:JAKs [plasma membrane] (Bos taurus)
IL6:IL6R [plasma membrane] (Bos taurus)
IL6 receptor trimer:JAKs [plasma membrane] (Bos taurus)
IL6:IL6RA:IL6RB:JAKs [plasma membrane] (Bos taurus)
IL6:IL6R [plasma membrane] (Bos taurus)
IL6 binds IL6R (Bos taurus)
IL6:IL6R [plasma membrane] (Bos taurus)
IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Bos taurus)
IL6:IL6R [plasma membrane] (Bos taurus)
IL6:IL6RA:IL6RB:JAKs [plasma membrane] (Bos taurus)
IL6:IL6R [plasma membrane] (Bos taurus)
IL6ST is tyrosine phosphorylated (Bos taurus)
IL6 receptor hexamer:Activated JAKs [plasma membrane] (Bos taurus)
IL6 receptor trimer:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6RA:IL6RB:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6R [plasma membrane] (Bos taurus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6R [plasma membrane] (Bos taurus)
JAK activation (Bos taurus)
IL6 receptor hexamer:Activated JAKs [plasma membrane] (Bos taurus)
IL6 receptor trimer:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6RA:IL6RB:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6R [plasma membrane] (Bos taurus)
IL6 receptor hexamer:JAKs [plasma membrane] (Bos taurus)
IL6 receptor trimer:JAKs [plasma membrane] (Bos taurus)
IL6:IL6RA:IL6RB:JAKs [plasma membrane] (Bos taurus)
IL6:IL6R [plasma membrane] (Bos taurus)
PTPN11 binds CBL (Bos taurus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Bos taurus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6R [plasma membrane] (Bos taurus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11:CBL [plasma membrane] (Bos taurus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Bos taurus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6R [plasma membrane] (Bos taurus)
PTPN11 binds p-Y759-IL6ST (Bos taurus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6R [plasma membrane] (Bos taurus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Bos taurus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6R [plasma membrane] (Bos taurus)
PTPN11 is phosphorylated (Bos taurus)
IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Bos taurus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6R [plasma membrane] (Bos taurus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Bos taurus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6R [plasma membrane] (Bos taurus)
Phosphorylated STATs are released (Bos taurus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6R [plasma membrane] (Bos taurus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane] (Bos taurus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6R [plasma membrane] (Bos taurus)
SOCS3 binds IL6ST (Bos taurus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6R [plasma membrane] (Bos taurus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] (Bos taurus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6R [plasma membrane] (Bos taurus)
Serine phosphorylation of STATs (Bos taurus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane] (Bos taurus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6R [plasma membrane] (Bos taurus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine/serine phosphorylated STAT1/3 [plasma membrane] (Bos taurus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6R [plasma membrane] (Bos taurus)
Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Bos taurus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6R [plasma membrane] (Bos taurus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT1,STAT3 [plasma membrane] (Bos taurus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6R [plasma membrane] (Bos taurus)
Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Bos taurus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] (Bos taurus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6R [plasma membrane] (Bos taurus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT1,STAT3 [plasma membrane] (Bos taurus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6R [plasma membrane] (Bos taurus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane] (Bos taurus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6R [plasma membrane] (Bos taurus)
Signal Transduction (Bos taurus)
MAPK family signaling cascades (Bos taurus)
MAPK1/MAPK3 signaling (Bos taurus)
RAF-independent MAPK1/3 activation (Bos taurus)
MAPK1 (ERK2) activation (Bos taurus)
MAP2K2 binds MAPK1 (Bos taurus)
IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Bos taurus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6R [plasma membrane] (Bos taurus)
MAPK3 (ERK1) activation (Bos taurus)
MAP2K1 binds MAPK3 (Bos taurus)
IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Bos taurus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6R [plasma membrane] (Bos taurus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
IL6 [extracellular region]
(Bos taurus)
IL6R [plasma membrane]
(Bos taurus)
Participates
as a component of
IL6:IL6RA:IL6RB:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6RA:IL6RB:JAKs [plasma membrane] (Bos taurus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Bos taurus)
as an input of
IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Bos taurus)
as an output of
IL6 binds IL6R (Bos taurus)
Inferred From
IL6:IL6R [plasma membrane]
(Homo sapiens)
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