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PML [nucleoplasm]
Stable Identifier
R-BTA-1031706
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
nucleoplasm
Synonyms
PML, A0A3Q1M8R6
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Bos taurus)
RNA Polymerase II Transcription (Bos taurus)
Generic Transcription Pathway (Bos taurus)
Transcriptional Regulation by TP53 (Bos taurus)
Regulation of TP53 Activity (Bos taurus)
Regulation of TP53 Activity through Acetylation (Bos taurus)
KAT6A acetylates TP53 (Bos taurus)
KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:Ac-K120,K382,p-S15,S20-TP53 Tetramer [nucleoplasm] (Bos taurus)
PML [nucleoplasm] (Bos taurus)
KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:p-S15,S20-TP53 [nucleoplasm] (Bos taurus)
PML [nucleoplasm] (Bos taurus)
KAT6A and PML bind TP53 (Bos taurus)
KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:p-S15,S20-TP53 [nucleoplasm] (Bos taurus)
PML [nucleoplasm] (Bos taurus)
PML [nucleoplasm] (Bos taurus)
MTA2-NuRD complex deacetylates TP53 (Bos taurus)
BRD7:Ac-K382,p-S15,S20-TP53:EP300, KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (Bos taurus)
KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:Ac-K120,K382,p-S15,S20-TP53 Tetramer [nucleoplasm] (Bos taurus)
PML [nucleoplasm] (Bos taurus)
KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:Ac-K120,p-S15,S20-TP53, BRD7:p-S15,S20-TP53:EP300 [nucleoplasm] (Bos taurus)
KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:Ac-K120,p-S15,S20-TP53 Tetramer [nucleoplasm] (Bos taurus)
PML [nucleoplasm] (Bos taurus)
Transcriptional regulation by RUNX1 (Bos taurus)
Regulation of RUNX1 Expression and Activity (Bos taurus)
PML binds RUNX1 (Bos taurus)
PML [nucleoplasm] (Bos taurus)
RUNX1:PML [nucleoplasm] (Bos taurus)
PML [nucleoplasm] (Bos taurus)
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
SUMOylation (Bos taurus)
SUMO E3 ligases SUMOylate target proteins (Bos taurus)
SUMOylation of DNA damage response and repair proteins (Bos taurus)
RANBP2 SUMOylates PML with SUMO1 (Bos taurus)
PML [nucleoplasm] (Bos taurus)
RANBP2 SUMOylates PML with SUMO2 (Bos taurus)
PML [nucleoplasm] (Bos taurus)
SUMOylation of PML with SUMO3 (Bos taurus)
PML [nucleoplasm] (Bos taurus)
UBE2I, HDAC7 SUMOylate PML with SUMO1 (Bos taurus)
PML [nucleoplasm] (Bos taurus)
SUMOylation of ubiquitinylation proteins (Bos taurus)
PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 (Bos taurus)
PML,TRIM27,PIAS1,2-1 [nucleoplasm] (Bos taurus)
PML [nucleoplasm] (Bos taurus)
Signal Transduction (Bos taurus)
Intracellular signaling by second messengers (Bos taurus)
PIP3 activates AKT signaling (Bos taurus)
PTEN Regulation (Bos taurus)
Regulation of PTEN localization (Bos taurus)
USP7 deubiquitinates monoubiquitinated PTEN (Bos taurus)
PML [nucleoplasm] (Bos taurus)
External Reference Information
External Reference
UniProt:A0A3Q1M8R6
Gene Names
PML
Reference Genes
BioGPS Gene:100138545 PML
ENSEMBL:ENSBTAG00000015779.6
ENSEMBL:ENSBTAG00000015779.7 PML
Monarch:100138545 PML
NCBI Gene:100138545 PML
Reference Transcript
RefSeq:XM_005221906.3 PML
Other Identifiers
100138545
GO:0000278
GO:0000781
GO:0000792
GO:0001666
GO:0002376
GO:0005634
GO:0005654
GO:0005694
GO:0005730
GO:0005737
GO:0005829
GO:0006281
GO:0006351
GO:0006355
GO:0006606
GO:0006886
GO:0006913
GO:0006977
GO:0007155
GO:0007179
GO:0008285
GO:0008630
GO:0008631
GO:0009411
GO:0010332
GO:0010522
GO:0010761
GO:0012501
GO:0016363
GO:0016525
GO:0016605
GO:0023052
GO:0030099
GO:0030154
GO:0030155
GO:0030163
GO:0030308
GO:0030578
GO:0031503
GO:0031625
GO:0032183
GO:0032200
GO:0032206
GO:0032469
GO:0032691
GO:0032692
GO:0032922
GO:0034097
GO:0036211
GO:0042752
GO:0042771
GO:0042803
GO:0043153
GO:0043161
GO:0043226
GO:0044790
GO:0045087
GO:0045165
GO:0045892
GO:0046332
GO:0048146
GO:0048384
GO:0048856
GO:0048870
GO:0051457
GO:0055065
GO:0055085
GO:0060090
GO:0060395
GO:0060444
GO:0065003
GO:0070059
GO:0071353
GO:0072332
GO:0090398
GO:0090402
GO:0097191
GO:0098542
GO:0140037
GO:1901798
GO:1990830
GO:2000059
GO:2000758
GO:2000779
GO:2001235
GO:2001238
Participates
as a member of
PML,TRIM27,PIAS1,2-1 [nucleoplasm] (Bos taurus)
as an input of
SUMOylation of PML with SUMO3 (Bos taurus)
RANBP2 SUMOylates PML with SUMO2 (Bos taurus)
RANBP2 SUMOylates PML with SUMO1 (Bos taurus)
UBE2I, HDAC7 SUMOylate PML with SUMO1 (Bos taurus)
PML binds RUNX1 (Bos taurus)
KAT6A and PML bind TP53 (Bos taurus)
as a component of
RUNX1:PML [nucleoplasm] (Bos taurus)
KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:Ac-K120,p-S15,S20-TP53 Tetramer [nucleoplasm] (Bos taurus)
KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:Ac-K120,K382,p-S15,S20-TP53 Tetramer [nucleoplasm] (Bos taurus)
KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:p-S15,S20-TP53 [nucleoplasm] (Bos taurus)
This entity regulates
Negatively
USP7 deubiquitinates monoubiquitinated PTEN
(Bos taurus)
Other forms of this molecule
PML [nucleoplasm]
PML [nucleoplasm]
PML [nucleoplasm]
Inferred From
PML [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
XP_005221963.1
OpenTargets
ENSG00000140464
Ensembl
ENSBTAP00000070324
,
ENSBTAT00000070043
,
ENSBTAG00000015779
VGNC
99292
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