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EF [endosome membrane]
Stable Identifier
R-BAN-5210938
Type
Protein [EntityWithAccessionedSequence]
Species
Bacillus anthracis
Compartment
endosome membrane
Synonyms
EF(34-800), Edema factor, Calmodulin-sensitive adenylate cyclase, cya, cya(34-800)
GO Cellular Component
host cell endosome membrane
(0044175)
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Bacterial Infection Pathways (Homo sapiens)
Uptake and actions of bacterial toxins (Homo sapiens)
Uptake and function of anthrax toxins (Homo sapiens)
Endocytosis of cya:lef:(pagA(197-794):ANTXR1 oligomer) (plasma membrane to endosome membrane) (Homo sapiens)
cya:lef:(pagA(197-794):ANTXR1 oligomer) [endosome membrane] (Homo sapiens)
EF [endosome membrane] (Bacillus anthracis)
Endocytosis of cya:lef:(pagA(197-794):ANTXR2 oligomer) (plasma membrane to endosome membrane) (Homo sapiens)
cya:lef:(pagA(197-794):ANTXR2 oligomer) [endosome membrane] (Homo sapiens)
EF [endosome membrane] (Bacillus anthracis)
pagA(197-794):ANTRX1 oligomer transports cya and lef (target cell endosome to cytosol) (Homo sapiens)
cya:lef:(pagA(197-794):ANTXR1 oligomer) [endosome membrane] (Homo sapiens)
EF [endosome membrane] (Bacillus anthracis)
pagA(197-794):ANTRX2 oligomer transports cya and lef (target cell endosome to cytosol) (Homo sapiens)
cya:lef:(pagA(197-794):ANTXR2 oligomer) [endosome membrane] (Homo sapiens)
EF [endosome membrane] (Bacillus anthracis)
Literature References
PubMed ID
Title
Journal
Year
3149607
Nucleotide sequence of the Bacillus anthracis edema factor gene (cya): a calmodulin-dependent adenylate cyclase
Robertson, DL
,
Tippetts, MT
,
Leppla, SH
Gene
1988
External Reference Information
External Reference
UniProt:P40136 cya
Gene Names
cya, pXO1-122, BXA0141, GBAA_pXO1_0142
Chain
signal peptide:1-33, chain:34-800
Reference Genes
BioGPS Gene:45025501 cya
KEGG:bar:GBAA_pXO1_0142 cya
Monarch:45025501 cya
NCBI Gene:45025501 cya
UCSC:P40136 cya
Reference Transcript
RefSeq:NC_001496.1 pagA
RefSeq:NZ_VTZH01000015.1 pagA
Participates
as a component of
cya:lef:(pagA(197-794):ANTXR1 oligomer) [endosome membrane] (Homo sapiens)
cya:lef:(pagA(197-794):ANTXR2 oligomer) [endosome membrane] (Homo sapiens)
Other forms of this molecule
cya [cytosol]
cya [extracellular region]
cya [plasma membrane]
Disease
Name
Identifier
Synonyms
anthrax disease
DOID:7427
Cross References
RefSeq
WP_000197748.1
,
NP_052818.1
Mondo
0005119
ZINC - Substances
CYAA_BACAN
ZINC target
P40136
PRO
P40136
ZINC - Predictions - Purchasable
CYAA_BACAN
PDB
6UZD
,
1XFV
,
6UZE
,
1XFU
,
1LVC
,
6UZB
,
1K8T
,
1K93
,
1K90
,
1PK0
,
1S26
,
6VRA
,
1Y0V
,
1SK6
,
1XFW
,
1XFY
,
1XFX
,
1XFZ
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62158 CALM
0.871
10
UniProt:P62155 CALM
0.623
2
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