PA63 [endosome membrane]

Stable Identifier
R-BAN-5210910
Type
Protein [EntityWithAccessionedSequence]
Species
Bacillus anthracis
Compartment
endosome membrane
Synonyms
PA(197-764), Protective antigen large fragment, pagA largel fragment, pagA(197-794)
GO Cellular Component
host cell endosome membrane (0044175)
Icon
PA63 [endosome membrane] icon
PA63 [endosome membrane] icon
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
1644824 Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen

Klimpel, KR, Leppla, SH, Molloy, S S, Thomas, G, Bresnahan, PA

J. Biol. Chem. 1992
1438214 Anthrax toxin protective antigen is activated by a cell surface protease with the sequence specificity and catalytic properties of furin

Klimpel, KR, Leppla, SH, Molloy, S S, Thomas, G

Proc. Natl. Acad. Sci. U.S.A. 1992
External Reference Information
External Reference
UniProt:P13423 pagA
Gene Names
pagA, pag, pXO1-110, BXA0164, GBAA_pXO1_0164
Chain
signal peptide:1-29, chain:30-764, chain:30-196, chain:197-764
Reference Genes
BioGPS Gene:45025512 pagA
KEGG Gene (Bacillus anthracis Ames Ancestor):GBAA_pXO1_0164 pagA
Monarch:45025512 pagA
NCBI Gene:45025512 pagA
Reference Transcript
Participates
as a component of
Other forms of this molecule
pagA [extracellular region]
pagA(30-196) [extracellular region]
pagA [plasma membrane]
pagA(197-794) [plasma membrane]
Disease
Name Identifier Synonyms
anthrax disease DOID:7427
Cross References
RefSeq
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
ZINC - Predictions - Purchasable
PDB
Interactors (5)
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