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pagA [plasma membrane]
Stable Identifier
R-BAN-5205702
Type
Protein [EntityWithAccessionedSequence]
Species
Bacillus anthracis
Compartment
plasma membrane
Synonyms
PA83, PA, PA(30-764), Protective antigen, pagA(30-794)
GO Cellular Component
host cell plasma membrane
(0020002)
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Bacterial Infection Pathways (Homo sapiens)
Uptake and actions of bacterial toxins (Homo sapiens)
Uptake and function of anthrax toxins (Homo sapiens)
Furin cleaves ANTXR1-bound pagA to yield pagA(197-794) (Homo sapiens)
pagA:ANTXR1 [plasma membrane] (Homo sapiens)
pagA:Ca2+ [plasma membrane] (Bacillus anthracis)
pagA [plasma membrane] (Bacillus anthracis)
Furin cleaves ANTXR2-bound pagA to yield pagA(197-794) (Homo sapiens)
pagA:ANTXR2 [plasma membrane] (Homo sapiens)
pagA:Ca2+ [plasma membrane] (Bacillus anthracis)
pagA [plasma membrane] (Bacillus anthracis)
pagA binds ANTXR1 (Homo sapiens)
pagA:ANTXR1 [plasma membrane] (Homo sapiens)
pagA:Ca2+ [plasma membrane] (Bacillus anthracis)
pagA [plasma membrane] (Bacillus anthracis)
pagA binds ANTXR2 (Homo sapiens)
pagA:ANTXR2 [plasma membrane] (Homo sapiens)
pagA:Ca2+ [plasma membrane] (Bacillus anthracis)
pagA [plasma membrane] (Bacillus anthracis)
Literature References
PubMed ID
Title
Journal
Year
9039918
Crystal structure of the anthrax toxin protective antigen
Klimpel, KR
,
Leppla, SH
,
Petosa, C
,
Collier, RJ
,
Liddington, RC
Nature
1997
External Reference Information
External Reference
UniProt:P13423 pagA
Gene Names
pagA, pag, pXO1-110, BXA0164, GBAA_pXO1_0164
Chain
signal peptide:1-29, chain:30-764, chain:30-196, chain:197-764
Reference Genes
BioGPS Gene:45025512 pagA
KEGG Gene (Bacillus anthracis Ames Ancestor):GBAA_pXO1_0164 pagA
Monarch:45025512 pagA
NCBI Gene:45025512 pagA
Reference Transcript
RefSeq:NZ_VTZH01000015.1 pagA
RefSeq:NZ_QAEM01000007.1 pagA
RefSeq:NZ_SDEF01000130.1 pagA
RefSeq:NC_001496.1 pagA
Participates
as a component of
pagA:Ca2+ [plasma membrane] (Bacillus anthracis)
Other forms of this molecule
pagA [extracellular region]
pagA(30-196) [extracellular region]
PA63 [endosome membrane]
pagA(197-794) [plasma membrane]
Disease
Name
Identifier
Synonyms
anthrax disease
DOID:7427
Cross References
RefSeq
WP_000746488.1
,
WP_000746487.1
,
WP_000746486.1
,
NP_052806.1
ZINC - Substances
PAG_BACAN
ZINC - Biogenic
PAG_BACAN
ZINC target
P13423
PRO
P13423
ZINC - Predictions - Purchasable
PAG_BACAN
PDB
6ZXJ
,
4H2A
,
6ZXK
,
3TEY
,
6UJI
,
3TEX
,
3TEW
,
1T6B
,
1ACC
,
6UZE
,
1TZN
,
5FR3
,
6VRA
,
7O85
,
6UZB
,
6UZD
,
4EE2
,
1TZO
,
3INO
,
7KXR
,
4NAM
,
3ETB
,
3Q8F
,
3J9C
,
3MHZ
,
6PSN
,
3Q8B
,
3Q8A
,
3TEZ
,
3KWV
,
6ZXL
,
3Q8E
,
6WJJ
,
3Q8C
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P13423 pagA
5
pagA [extracellular region]
(R-BAN-5205707)
pagA(30-196) [extracellular region]
(R-BAN-5205700)
pagA [plasma membrane]
(R-BAN-5205702)
PA63 [endosome membrane]
(R-BAN-5210910)
pagA(197-794) [plasma membrane]
(R-BAN-5205715)
0.964
16
UniProt:P15917 lef
4
lef [cytosol]
(R-BAN-5210955)
lef [extracellular region]
(R-BAN-5205720)
LF [endosome membrane]
(R-BAN-5210898)
lef [plasma membrane]
(R-BAN-5210926)
0.962
28
UniProt:P58335 ANTXR2
0.786
7
UniProt:Q9H6X2-2 ANTXR1
2
ANTXR1-2 [plasma membrane]
(R-HSA-5210021)
ANTXR1-2 [endosome membrane]
(R-HSA-5210903)
0.611
3
UniProt:P0A6F5 CH60
0.522
2
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