Reactome | carprofen [cytosol]

carprofen [cytosol]

Stable Identifier

R-ALL-9716728

Type

ChemicalDrug

Compartment

cytosol

Locations in the PathwayBrowser

for Species:

Expand all

Metabolism (Canis familiaris)

- Metabolism of lipids (Canis familiaris)
  - Fatty acid metabolism (Canis familiaris)
    - Arachidonate metabolism (Canis familiaris)
      - Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Canis familiaris)
        
        PGG2 is reduced to PGH2 by PTGS2 (Canis familiaris)
        
        PTGS2 dimer:PTGS2 inhibitors [endoplasmic reticulum membrane] (Canis familiaris)
        
        PTGS2 inhibitors [cytosol]
        
        carprofen [cytosol]
        
        PTGS2 dimer binds PTGS2 inhibitors (Canis familiaris)
        
        PTGS2 inhibitors [cytosol]
        
        carprofen [cytosol]
        
        PTGS2 dimer:PTGS2 inhibitors [endoplasmic reticulum membrane] (Canis familiaris)
        
        PTGS2 inhibitors [cytosol]
        
        carprofen [cytosol]

Metabolism (Danio rerio)

- Metabolism of lipids (Danio rerio)
  - Fatty acid metabolism (Danio rerio)
    - Arachidonate metabolism (Danio rerio)
      - Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Danio rerio)
        
        PGG2 is reduced to PGH2 by PTGS2 (Danio rerio)
        
        PTGS2 dimer:PTGS2 inhibitors [endoplasmic reticulum membrane] (Danio rerio)
        
        PTGS2 inhibitors [cytosol]
        
        carprofen [cytosol]
        
        PTGS2 dimer binds PTGS2 inhibitors (Danio rerio)
        
        PTGS2 inhibitors [cytosol]
        
        carprofen [cytosol]
        
        PTGS2 dimer:PTGS2 inhibitors [endoplasmic reticulum membrane] (Danio rerio)
        
        PTGS2 inhibitors [cytosol]
        
        carprofen [cytosol]

Metabolism (Gallus gallus)

- Metabolism of lipids (Gallus gallus)
  - Fatty acid metabolism (Gallus gallus)
    - Arachidonate metabolism (Gallus gallus)
      - Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Gallus gallus)
        
        PGG2 is reduced to PGH2 by PTGS2 (Gallus gallus)
        
        PTGS2 dimer:PTGS2 inhibitors [endoplasmic reticulum membrane] (Gallus gallus)
        
        PTGS2 inhibitors [cytosol]
        
        carprofen [cytosol]
        
        PTGS2 dimer binds PTGS2 inhibitors (Gallus gallus)
        
        PTGS2 inhibitors [cytosol]
        
        carprofen [cytosol]
        
        PTGS2 dimer:PTGS2 inhibitors [endoplasmic reticulum membrane] (Gallus gallus)
        
        PTGS2 inhibitors [cytosol]
        
        carprofen [cytosol]

Metabolism (Homo sapiens)

- Metabolism of lipids (Homo sapiens)
  - Fatty acid metabolism (Homo sapiens)
    - Arachidonate metabolism (Homo sapiens)
      - Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Homo sapiens)
        
        PGG2 is reduced to PGH2 by PTGS2 (Homo sapiens)
        
        PTGS2 dimer:PTGS2 inhibitors [endoplasmic reticulum membrane] (Homo sapiens)
        
        PTGS2 inhibitors [cytosol]
        
        carprofen [cytosol]
        
        PTGS2 dimer binds PTGS2 inhibitors (Homo sapiens)
        
        PTGS2 inhibitors [cytosol]
        
        carprofen [cytosol]
        
        PTGS2 dimer:PTGS2 inhibitors [endoplasmic reticulum membrane] (Homo sapiens)
        
        PTGS2 inhibitors [cytosol]
        
        carprofen [cytosol]

Metabolism (Mus musculus)

- Metabolism of lipids (Mus musculus)
  - Fatty acid metabolism (Mus musculus)
    - Arachidonate metabolism (Mus musculus)
      - Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Mus musculus)
        
        PGG2 is reduced to PGH2 by PTGS2 (Mus musculus)
        
        PTGS2 dimer:PTGS2 inhibitors [endoplasmic reticulum membrane] (Mus musculus)
        
        PTGS2 inhibitors [cytosol]
        
        carprofen [cytosol]
        
        PTGS2 dimer binds PTGS2 inhibitors (Mus musculus)
        
        PTGS2 inhibitors [cytosol]
        
        carprofen [cytosol]
        
        PTGS2 dimer:PTGS2 inhibitors [endoplasmic reticulum membrane] (Mus musculus)
        
        PTGS2 inhibitors [cytosol]
        
        carprofen [cytosol]

Metabolism (Rattus norvegicus)

- Metabolism of lipids (Rattus norvegicus)
  - Fatty acid metabolism (Rattus norvegicus)
    - Arachidonate metabolism (Rattus norvegicus)
      - Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Rattus norvegicus)
        
        PGG2 is reduced to PGH2 by PTGS2 (Rattus norvegicus)
        
        PTGS2 dimer:PTGS2 inhibitors [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        PTGS2 inhibitors [cytosol]
        
        carprofen [cytosol]
        
        PTGS2 dimer binds PTGS2 inhibitors (Rattus norvegicus)
        
        PTGS2 inhibitors [cytosol]
        
        carprofen [cytosol]
        
        PTGS2 dimer:PTGS2 inhibitors [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        PTGS2 inhibitors [cytosol]
        
        carprofen [cytosol]

Metabolism (Xenopus tropicalis)

- Metabolism of lipids (Xenopus tropicalis)
  - Fatty acid metabolism (Xenopus tropicalis)
    - Arachidonate metabolism (Xenopus tropicalis)
      - Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Xenopus tropicalis)
        
        PGG2 is reduced to PGH2 by PTGS2 (Xenopus tropicalis)
        
        PTGS2 dimer:PTGS2 inhibitors [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        PTGS2 inhibitors [cytosol]
        
        carprofen [cytosol]
        
        PTGS2 dimer binds PTGS2 inhibitors (Xenopus tropicalis)
        
        PTGS2 inhibitors [cytosol]
        
        carprofen [cytosol]
        
        PTGS2 dimer:PTGS2 inhibitors [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        PTGS2 inhibitors [cytosol]
        
        carprofen [cytosol]

External Reference Information

External Reference

carprofen [Guide to Pharmacology:7141]

Participates

as a member of

PTGS2 inhibitors [cytosol]

Disease

Name	Identifier	Synonyms
inflammation	SYMP:0000061

Cross References

ChEBI

364453, 364453

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