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alectinib [cytosol]
Stable Identifier
R-ALL-9699608
Type
ChemicalDrug
Compartment
cytosol
Synonyms
AF802, Alecensa®, CH5424802
Icon
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Canis familiaris
Danio rerio
Gallus gallus
Mus musculus
Rattus norvegicus
Sus scrofa
Expand all
Signal Transduction (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by ALK (Bos taurus)
ALK autophosphorylation (Bos taurus)
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Bos taurus)
type I ALK-binding TKIs [cytosol]
alectinib [cytosol]
Liganded-ALK dimer binds type I ALK-binding TKIs (Bos taurus)
type I ALK-binding TKIs [cytosol]
alectinib [cytosol]
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Bos taurus)
type I ALK-binding TKIs [cytosol]
alectinib [cytosol]
Signal Transduction (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by ALK (Canis familiaris)
ALK autophosphorylation (Canis familiaris)
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Canis familiaris)
type I ALK-binding TKIs [cytosol]
alectinib [cytosol]
Liganded-ALK dimer binds type I ALK-binding TKIs (Canis familiaris)
type I ALK-binding TKIs [cytosol]
alectinib [cytosol]
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Canis familiaris)
type I ALK-binding TKIs [cytosol]
alectinib [cytosol]
Signal Transduction (Danio rerio)
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by ALK (Danio rerio)
ALK autophosphorylation (Danio rerio)
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Danio rerio)
type I ALK-binding TKIs [cytosol]
alectinib [cytosol]
Liganded-ALK dimer binds type I ALK-binding TKIs (Danio rerio)
type I ALK-binding TKIs [cytosol]
alectinib [cytosol]
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Danio rerio)
type I ALK-binding TKIs [cytosol]
alectinib [cytosol]
Signal Transduction (Gallus gallus)
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by ALK (Gallus gallus)
ALK autophosphorylation (Gallus gallus)
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Gallus gallus)
type I ALK-binding TKIs [cytosol]
alectinib [cytosol]
Liganded-ALK dimer binds type I ALK-binding TKIs (Gallus gallus)
type I ALK-binding TKIs [cytosol]
alectinib [cytosol]
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Gallus gallus)
type I ALK-binding TKIs [cytosol]
alectinib [cytosol]
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by ALK in cancer (Homo sapiens)
ALK mutants bind TKIs (Homo sapiens)
ALK mutants bind type I TKIs (Homo sapiens)
type I ALK-binding TKIs [cytosol]
alectinib [cytosol]
type I ALK-binding TKIs:type I-sensitive ALK mutants [cytosol] (Homo sapiens)
type I ALK-binding TKIs [cytosol]
alectinib [cytosol]
Drug resistance of ALK mutants (Homo sapiens)
alectinib-resistant ALK mutants (Homo sapiens)
alectinib resistant ALK mutants don't bind alectinib (Homo sapiens)
alectinib [cytosol]
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ALK (Homo sapiens)
ALK autophosphorylation (Homo sapiens)
type I ALK-binding TKIs [cytosol]
alectinib [cytosol]
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Homo sapiens)
type I ALK-binding TKIs [cytosol]
alectinib [cytosol]
Liganded-ALK dimer binds type I ALK-binding TKIs (Homo sapiens)
type I ALK-binding TKIs [cytosol]
alectinib [cytosol]
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Homo sapiens)
type I ALK-binding TKIs [cytosol]
alectinib [cytosol]
Signal Transduction (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by ALK (Mus musculus)
ALK autophosphorylation (Mus musculus)
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Mus musculus)
type I ALK-binding TKIs [cytosol]
alectinib [cytosol]
Liganded-ALK dimer binds type I ALK-binding TKIs (Mus musculus)
type I ALK-binding TKIs [cytosol]
alectinib [cytosol]
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Mus musculus)
type I ALK-binding TKIs [cytosol]
alectinib [cytosol]
Signal Transduction (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by ALK (Rattus norvegicus)
ALK autophosphorylation (Rattus norvegicus)
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Rattus norvegicus)
type I ALK-binding TKIs [cytosol]
alectinib [cytosol]
Liganded-ALK dimer binds type I ALK-binding TKIs (Rattus norvegicus)
type I ALK-binding TKIs [cytosol]
alectinib [cytosol]
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Rattus norvegicus)
type I ALK-binding TKIs [cytosol]
alectinib [cytosol]
Signal Transduction (Sus scrofa)
Signaling by Receptor Tyrosine Kinases (Sus scrofa)
Signaling by ALK (Sus scrofa)
ALK autophosphorylation (Sus scrofa)
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Sus scrofa)
type I ALK-binding TKIs [cytosol]
alectinib [cytosol]
Liganded-ALK dimer binds type I ALK-binding TKIs (Sus scrofa)
type I ALK-binding TKIs [cytosol]
alectinib [cytosol]
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Sus scrofa)
type I ALK-binding TKIs [cytosol]
alectinib [cytosol]
External Reference Information
External Reference
alectinib [Guide to Pharmacology:7739]
Participates
as an input of
alectinib resistant ALK mutants don't bind alectinib (Homo sapiens)
as a member of
type I ALK-binding TKIs [cytosol]
Disease
Name
Identifier
Synonyms
cancer
DOID:162
malignant tumor, malignant neoplasm, primary cancer
Cross References
Pharos - Ligands
CBZSLNV1JKXP
PharmacoDB
PDBC02120
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![alectinib [cytosol] icon](/icon/R-ICO-014388.svg){kind=icon}
