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pitolisant [extracellular region]
Stable Identifier
R-ALL-9692536
Type
ChemicalDrug
Compartment
extracellular region
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Drosophila melanogaster
Gallus gallus
Mus musculus
Rattus norvegicus
Sus scrofa
Xenopus tropicalis
Expand all
Signal Transduction (Bos taurus)
Signaling by GPCR (Bos taurus)
GPCR ligand binding (Bos taurus)
Class A/1 (Rhodopsin-like receptors) (Bos taurus)
Amine ligand-binding receptors (Bos taurus)
Histamine receptors (Bos taurus)
HRH3 binds pitosilant (Bos taurus)
pitolisant [extracellular region]
HRH3:pitosilant [plasma membrane] (Bos taurus)
pitolisant [extracellular region]
Signal Transduction (Caenorhabditis elegans)
Signaling by GPCR (Caenorhabditis elegans)
GPCR ligand binding (Caenorhabditis elegans)
Class A/1 (Rhodopsin-like receptors) (Caenorhabditis elegans)
Amine ligand-binding receptors (Caenorhabditis elegans)
Histamine receptors (Caenorhabditis elegans)
HRH1 binds HRH1 inverse agonists (Caenorhabditis elegans)
HRH1 inverse agonists [extracellular region]
pitolisant [extracellular region]
HRH1:HRH1 inverse agonists [plasma membrane] (Caenorhabditis elegans)
HRH1 inverse agonists [extracellular region]
pitolisant [extracellular region]
HRH3 binds pitosilant (Caenorhabditis elegans)
pitolisant [extracellular region]
HRH3:pitosilant [plasma membrane] (Caenorhabditis elegans)
pitolisant [extracellular region]
Signal Transduction (Canis familiaris)
Signaling by GPCR (Canis familiaris)
GPCR ligand binding (Canis familiaris)
Class A/1 (Rhodopsin-like receptors) (Canis familiaris)
Amine ligand-binding receptors (Canis familiaris)
Histamine receptors (Canis familiaris)
HRH1 binds HRH1 inverse agonists (Canis familiaris)
HRH1 inverse agonists [extracellular region]
pitolisant [extracellular region]
HRH1:HRH1 inverse agonists [plasma membrane] (Canis familiaris)
HRH1 inverse agonists [extracellular region]
pitolisant [extracellular region]
HRH3 binds pitosilant (Canis familiaris)
pitolisant [extracellular region]
HRH3:pitosilant [plasma membrane] (Canis familiaris)
pitolisant [extracellular region]
Signal Transduction (Drosophila melanogaster)
Signaling by GPCR (Drosophila melanogaster)
GPCR ligand binding (Drosophila melanogaster)
Class A/1 (Rhodopsin-like receptors) (Drosophila melanogaster)
Amine ligand-binding receptors (Drosophila melanogaster)
Histamine receptors (Drosophila melanogaster)
HRH3 binds pitosilant (Drosophila melanogaster)
pitolisant [extracellular region]
HRH3:pitosilant [plasma membrane] (Drosophila melanogaster)
pitolisant [extracellular region]
Signal Transduction (Gallus gallus)
Signaling by GPCR (Gallus gallus)
GPCR ligand binding (Gallus gallus)
Class A/1 (Rhodopsin-like receptors) (Gallus gallus)
Amine ligand-binding receptors (Gallus gallus)
Histamine receptors (Gallus gallus)
HRH1 binds HRH1 inverse agonists (Gallus gallus)
HRH1 inverse agonists [extracellular region]
pitolisant [extracellular region]
HRH1:HRH1 inverse agonists [plasma membrane] (Gallus gallus)
HRH1 inverse agonists [extracellular region]
pitolisant [extracellular region]
HRH3 binds pitosilant (Gallus gallus)
pitolisant [extracellular region]
HRH3:pitosilant [plasma membrane] (Gallus gallus)
pitolisant [extracellular region]
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Amine ligand-binding receptors (Homo sapiens)
Histamine receptors (Homo sapiens)
HRH1 binds HRH1 inverse agonists (Homo sapiens)
HRH1 inverse agonists [extracellular region]
pitolisant [extracellular region]
HRH1:HRH1 inverse agonists [plasma membrane] (Homo sapiens)
HRH1 inverse agonists [extracellular region]
pitolisant [extracellular region]
HRH3 binds pitosilant (Homo sapiens)
pitolisant [extracellular region]
HRH3:pitosilant [plasma membrane] (Homo sapiens)
pitolisant [extracellular region]
Signal Transduction (Mus musculus)
Signaling by GPCR (Mus musculus)
GPCR ligand binding (Mus musculus)
Class A/1 (Rhodopsin-like receptors) (Mus musculus)
Amine ligand-binding receptors (Mus musculus)
Histamine receptors (Mus musculus)
HRH1 binds HRH1 inverse agonists (Mus musculus)
HRH1 inverse agonists [extracellular region]
pitolisant [extracellular region]
HRH1:HRH1 inverse agonists [plasma membrane] (Mus musculus)
HRH1 inverse agonists [extracellular region]
pitolisant [extracellular region]
HRH3 binds pitosilant (Mus musculus)
pitolisant [extracellular region]
HRH3:pitosilant [plasma membrane] (Mus musculus)
pitolisant [extracellular region]
Signal Transduction (Rattus norvegicus)
Signaling by GPCR (Rattus norvegicus)
GPCR ligand binding (Rattus norvegicus)
Class A/1 (Rhodopsin-like receptors) (Rattus norvegicus)
Amine ligand-binding receptors (Rattus norvegicus)
Histamine receptors (Rattus norvegicus)
HRH1 binds HRH1 inverse agonists (Rattus norvegicus)
HRH1 inverse agonists [extracellular region]
pitolisant [extracellular region]
HRH1:HRH1 inverse agonists [plasma membrane] (Rattus norvegicus)
HRH1 inverse agonists [extracellular region]
pitolisant [extracellular region]
HRH3 binds pitosilant (Rattus norvegicus)
pitolisant [extracellular region]
HRH3:pitosilant [plasma membrane] (Rattus norvegicus)
pitolisant [extracellular region]
Signal Transduction (Sus scrofa)
Signaling by GPCR (Sus scrofa)
GPCR ligand binding (Sus scrofa)
Class A/1 (Rhodopsin-like receptors) (Sus scrofa)
Amine ligand-binding receptors (Sus scrofa)
Histamine receptors (Sus scrofa)
HRH1 binds HRH1 inverse agonists (Sus scrofa)
HRH1 inverse agonists [extracellular region]
pitolisant [extracellular region]
HRH1:HRH1 inverse agonists [plasma membrane] (Sus scrofa)
HRH1 inverse agonists [extracellular region]
pitolisant [extracellular region]
HRH3 binds pitosilant (Sus scrofa)
pitolisant [extracellular region]
HRH3:pitosilant [plasma membrane] (Sus scrofa)
pitolisant [extracellular region]
Signal Transduction (Xenopus tropicalis)
Signaling by GPCR (Xenopus tropicalis)
GPCR ligand binding (Xenopus tropicalis)
Class A/1 (Rhodopsin-like receptors) (Xenopus tropicalis)
Amine ligand-binding receptors (Xenopus tropicalis)
Histamine receptors (Xenopus tropicalis)
HRH1 binds HRH1 inverse agonists (Xenopus tropicalis)
HRH1 inverse agonists [extracellular region]
pitolisant [extracellular region]
HRH1:HRH1 inverse agonists [plasma membrane] (Xenopus tropicalis)
HRH1 inverse agonists [extracellular region]
pitolisant [extracellular region]
External Reference Information
External Reference
pitolisant [Guide to Pharmacology:8924]
Participates
as a member of
HRH1 inverse agonists [extracellular region]
as an input of
HRH3 binds pitosilant (Caenorhabditis elegans)
HRH3 binds pitosilant (Drosophila melanogaster)
HRH3 binds pitosilant (Gallus gallus)
HRH3 binds pitosilant (Sus scrofa)
HRH3 binds pitosilant (Bos taurus)
HRH3 binds pitosilant (Canis familiaris)
HRH3 binds pitosilant (Rattus norvegicus)
HRH3 binds pitosilant (Mus musculus)
HRH3 binds pitosilant (Homo sapiens)
as a component of
HRH3:pitosilant [plasma membrane] (Sus scrofa)
HRH3:pitosilant [plasma membrane] (Rattus norvegicus)
HRH3:pitosilant [plasma membrane] (Drosophila melanogaster)
HRH3:pitosilant [plasma membrane] (Gallus gallus)
HRH3:pitosilant [plasma membrane] (Caenorhabditis elegans)
HRH3:pitosilant [plasma membrane] (Mus musculus)
HRH3:pitosilant [plasma membrane] (Bos taurus)
HRH3:pitosilant [plasma membrane] (Canis familiaris)
HRH3:pitosilant [plasma membrane] (Homo sapiens)
Disease
Name
Identifier
Synonyms
narcolepsy
DOID:8986
Narcolepsy, without cataplexy, paroxysmal sleep
Cross References
Pharos - Ligands
SGNUZPNGMXH7
PharmacoDB
PDBC02426
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