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natalizumab [extracellular region]
Stable Identifier
R-ALL-9679737
Type
ProteinDrug
Compartment
extracellular region
Synonyms
AN100226, anti-alpha4 integrin, anti-VLA4, Tysabri®
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Drosophila melanogaster
Gallus gallus
Mus musculus
Rattus norvegicus
Sus scrofa
Xenopus tropicalis
Expand all
Extracellular matrix organization (Bos taurus)
Integrin cell surface interactions (Bos taurus)
ITGA4:ITGB1 binds natalizumab (Bos taurus)
natalizumab [extracellular region]
ITGA4:ITGB1:natalizumab [plasma membrane] (Bos taurus)
natalizumab [extracellular region]
Integrin alpha4beta1 binds JAM2:JAM3 (Bos taurus)
ITGA4:ITGB1:natalizumab [plasma membrane] (Bos taurus)
natalizumab [extracellular region]
VCAM1 binds Integrin alpha4beta1 (Bos taurus)
ITGA4:ITGB1:natalizumab [plasma membrane] (Bos taurus)
natalizumab [extracellular region]
Hemostasis (Bos taurus)
Cell surface interactions at the vascular wall (Bos taurus)
ITGA4:ITGB1 binds natalizumab (Bos taurus)
natalizumab [extracellular region]
ITGA4:ITGB1:natalizumab [plasma membrane] (Bos taurus)
natalizumab [extracellular region]
Integrin alpha4beta1 binds JAM2:JAM3 (Bos taurus)
ITGA4:ITGB1:natalizumab [plasma membrane] (Bos taurus)
natalizumab [extracellular region]
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Bos taurus)
ITGA4:ITGB1 binds natalizumab (Bos taurus)
natalizumab [extracellular region]
ITGA4:ITGB1:natalizumab [plasma membrane] (Bos taurus)
natalizumab [extracellular region]
VCAM1 binds Integrin alpha4beta1 (Bos taurus)
ITGA4:ITGB1:natalizumab [plasma membrane] (Bos taurus)
natalizumab [extracellular region]
Extracellular matrix organization (Caenorhabditis elegans)
Integrin cell surface interactions (Caenorhabditis elegans)
ITGA4:ITGB1 binds natalizumab (Caenorhabditis elegans)
natalizumab [extracellular region]
ITGA4:ITGB1:natalizumab [plasma membrane] (Caenorhabditis elegans)
natalizumab [extracellular region]
Hemostasis (Caenorhabditis elegans)
Cell surface interactions at the vascular wall (Caenorhabditis elegans)
ITGA4:ITGB1 binds natalizumab (Caenorhabditis elegans)
natalizumab [extracellular region]
ITGA4:ITGB1:natalizumab [plasma membrane] (Caenorhabditis elegans)
natalizumab [extracellular region]
Immune System (Caenorhabditis elegans)
Adaptive Immune System (Caenorhabditis elegans)
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Caenorhabditis elegans)
ITGA4:ITGB1 binds natalizumab (Caenorhabditis elegans)
natalizumab [extracellular region]
ITGA4:ITGB1:natalizumab [plasma membrane] (Caenorhabditis elegans)
natalizumab [extracellular region]
Extracellular matrix organization (Canis familiaris)
Integrin cell surface interactions (Canis familiaris)
ITGA4:ITGB1 binds natalizumab (Canis familiaris)
natalizumab [extracellular region]
ITGA4:ITGB1:natalizumab [plasma membrane] (Canis familiaris)
natalizumab [extracellular region]
Integrin alpha4beta1 binds JAM2:JAM3 (Canis familiaris)
ITGA4:ITGB1:natalizumab [plasma membrane] (Canis familiaris)
natalizumab [extracellular region]
VCAM1 binds Integrin alpha4beta1 (Canis familiaris)
ITGA4:ITGB1:natalizumab [plasma membrane] (Canis familiaris)
natalizumab [extracellular region]
Hemostasis (Canis familiaris)
Cell surface interactions at the vascular wall (Canis familiaris)
ITGA4:ITGB1 binds natalizumab (Canis familiaris)
natalizumab [extracellular region]
ITGA4:ITGB1:natalizumab [plasma membrane] (Canis familiaris)
natalizumab [extracellular region]
Integrin alpha4beta1 binds JAM2:JAM3 (Canis familiaris)
ITGA4:ITGB1:natalizumab [plasma membrane] (Canis familiaris)
natalizumab [extracellular region]
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Canis familiaris)
ITGA4:ITGB1 binds natalizumab (Canis familiaris)
natalizumab [extracellular region]
ITGA4:ITGB1:natalizumab [plasma membrane] (Canis familiaris)
natalizumab [extracellular region]
VCAM1 binds Integrin alpha4beta1 (Canis familiaris)
ITGA4:ITGB1:natalizumab [plasma membrane] (Canis familiaris)
natalizumab [extracellular region]
Extracellular matrix organization (Danio rerio)
Integrin cell surface interactions (Danio rerio)
ITGA4:ITGB1 binds natalizumab (Danio rerio)
natalizumab [extracellular region]
ITGA4:ITGB1:natalizumab [plasma membrane] (Danio rerio)
natalizumab [extracellular region]
Integrin alpha4beta1 binds JAM2:JAM3 (Danio rerio)
ITGA4:ITGB1:natalizumab [plasma membrane] (Danio rerio)
natalizumab [extracellular region]
VCAM1 binds Integrin alpha4beta1 (Danio rerio)
ITGA4:ITGB1:natalizumab [plasma membrane] (Danio rerio)
natalizumab [extracellular region]
Hemostasis (Danio rerio)
Cell surface interactions at the vascular wall (Danio rerio)
ITGA4:ITGB1 binds natalizumab (Danio rerio)
natalizumab [extracellular region]
ITGA4:ITGB1:natalizumab [plasma membrane] (Danio rerio)
natalizumab [extracellular region]
Integrin alpha4beta1 binds JAM2:JAM3 (Danio rerio)
ITGA4:ITGB1:natalizumab [plasma membrane] (Danio rerio)
natalizumab [extracellular region]
Immune System (Danio rerio)
Adaptive Immune System (Danio rerio)
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Danio rerio)
ITGA4:ITGB1 binds natalizumab (Danio rerio)
natalizumab [extracellular region]
ITGA4:ITGB1:natalizumab [plasma membrane] (Danio rerio)
natalizumab [extracellular region]
VCAM1 binds Integrin alpha4beta1 (Danio rerio)
ITGA4:ITGB1:natalizumab [plasma membrane] (Danio rerio)
natalizumab [extracellular region]
Extracellular matrix organization (Drosophila melanogaster)
Integrin cell surface interactions (Drosophila melanogaster)
ITGA4:ITGB1 binds natalizumab (Drosophila melanogaster)
natalizumab [extracellular region]
ITGA4:ITGB1:natalizumab [plasma membrane] (Drosophila melanogaster)
natalizumab [extracellular region]
Hemostasis (Drosophila melanogaster)
Cell surface interactions at the vascular wall (Drosophila melanogaster)
ITGA4:ITGB1 binds natalizumab (Drosophila melanogaster)
natalizumab [extracellular region]
ITGA4:ITGB1:natalizumab [plasma membrane] (Drosophila melanogaster)
natalizumab [extracellular region]
Immune System (Drosophila melanogaster)
Adaptive Immune System (Drosophila melanogaster)
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Drosophila melanogaster)
ITGA4:ITGB1 binds natalizumab (Drosophila melanogaster)
natalizumab [extracellular region]
ITGA4:ITGB1:natalizumab [plasma membrane] (Drosophila melanogaster)
natalizumab [extracellular region]
Extracellular matrix organization (Gallus gallus)
Integrin cell surface interactions (Gallus gallus)
ITGA4:ITGB1 binds natalizumab (Gallus gallus)
natalizumab [extracellular region]
ITGA4:ITGB1:natalizumab [plasma membrane] (Gallus gallus)
natalizumab [extracellular region]
Integrin alpha4beta1 binds JAM2:JAM3 (Gallus gallus)
ITGA4:ITGB1:natalizumab [plasma membrane] (Gallus gallus)
natalizumab [extracellular region]
Hemostasis (Gallus gallus)
Cell surface interactions at the vascular wall (Gallus gallus)
ITGA4:ITGB1 binds natalizumab (Gallus gallus)
natalizumab [extracellular region]
ITGA4:ITGB1:natalizumab [plasma membrane] (Gallus gallus)
natalizumab [extracellular region]
Integrin alpha4beta1 binds JAM2:JAM3 (Gallus gallus)
ITGA4:ITGB1:natalizumab [plasma membrane] (Gallus gallus)
natalizumab [extracellular region]
Immune System (Gallus gallus)
Adaptive Immune System (Gallus gallus)
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Gallus gallus)
ITGA4:ITGB1 binds natalizumab (Gallus gallus)
natalizumab [extracellular region]
ITGA4:ITGB1:natalizumab [plasma membrane] (Gallus gallus)
natalizumab [extracellular region]
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
Potential therapeutics for SARS (Homo sapiens)
ITGA4:ITGB1 binds natalizumab (Homo sapiens)
natalizumab [extracellular region]
ITGA4:ITGB1:natalizumab [plasma membrane] (Homo sapiens)
natalizumab [extracellular region]
Extracellular matrix organization (Homo sapiens)
Integrin cell surface interactions (Homo sapiens)
ITGA4:ITGB1 binds natalizumab (Homo sapiens)
natalizumab [extracellular region]
ITGA4:ITGB1:natalizumab [plasma membrane] (Homo sapiens)
natalizumab [extracellular region]
Integrin alpha4beta1 binds JAM2:JAM3 (Homo sapiens)
ITGA4:ITGB1:natalizumab [plasma membrane] (Homo sapiens)
natalizumab [extracellular region]
VCAM1 binds Integrin alpha4beta1 (Homo sapiens)
ITGA4:ITGB1:natalizumab [plasma membrane] (Homo sapiens)
natalizumab [extracellular region]
Hemostasis (Homo sapiens)
Cell surface interactions at the vascular wall (Homo sapiens)
ITGA4:ITGB1 binds natalizumab (Homo sapiens)
natalizumab [extracellular region]
ITGA4:ITGB1:natalizumab [plasma membrane] (Homo sapiens)
natalizumab [extracellular region]
Integrin alpha4beta1 binds JAM2:JAM3 (Homo sapiens)
ITGA4:ITGB1:natalizumab [plasma membrane] (Homo sapiens)
natalizumab [extracellular region]
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Homo sapiens)
ITGA4:ITGB1 binds natalizumab (Homo sapiens)
natalizumab [extracellular region]
ITGA4:ITGB1:natalizumab [plasma membrane] (Homo sapiens)
natalizumab [extracellular region]
VCAM1 binds Integrin alpha4beta1 (Homo sapiens)
ITGA4:ITGB1:natalizumab [plasma membrane] (Homo sapiens)
natalizumab [extracellular region]
Extracellular matrix organization (Mus musculus)
Integrin cell surface interactions (Mus musculus)
ITGA4:ITGB1 binds natalizumab (Mus musculus)
natalizumab [extracellular region]
ITGA4:ITGB1:natalizumab [plasma membrane] (Mus musculus)
natalizumab [extracellular region]
Integrin alpha4beta1 binds JAM2:JAM3 (Mus musculus)
ITGA4:ITGB1:natalizumab [plasma membrane] (Mus musculus)
natalizumab [extracellular region]
VCAM1 binds Integrin alpha4beta1 (Mus musculus)
ITGA4:ITGB1:natalizumab [plasma membrane] (Mus musculus)
natalizumab [extracellular region]
Hemostasis (Mus musculus)
Cell surface interactions at the vascular wall (Mus musculus)
ITGA4:ITGB1 binds natalizumab (Mus musculus)
natalizumab [extracellular region]
ITGA4:ITGB1:natalizumab [plasma membrane] (Mus musculus)
natalizumab [extracellular region]
Integrin alpha4beta1 binds JAM2:JAM3 (Mus musculus)
ITGA4:ITGB1:natalizumab [plasma membrane] (Mus musculus)
natalizumab [extracellular region]
Immune System (Mus musculus)
Adaptive Immune System (Mus musculus)
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Mus musculus)
ITGA4:ITGB1 binds natalizumab (Mus musculus)
natalizumab [extracellular region]
ITGA4:ITGB1:natalizumab [plasma membrane] (Mus musculus)
natalizumab [extracellular region]
VCAM1 binds Integrin alpha4beta1 (Mus musculus)
ITGA4:ITGB1:natalizumab [plasma membrane] (Mus musculus)
natalizumab [extracellular region]
Extracellular matrix organization (Rattus norvegicus)
Integrin cell surface interactions (Rattus norvegicus)
ITGA4:ITGB1 binds natalizumab (Rattus norvegicus)
natalizumab [extracellular region]
ITGA4:ITGB1:natalizumab [plasma membrane] (Rattus norvegicus)
natalizumab [extracellular region]
Integrin alpha4beta1 binds JAM2:JAM3 (Rattus norvegicus)
ITGA4:ITGB1:natalizumab [plasma membrane] (Rattus norvegicus)
natalizumab [extracellular region]
VCAM1 binds Integrin alpha4beta1 (Rattus norvegicus)
ITGA4:ITGB1:natalizumab [plasma membrane] (Rattus norvegicus)
natalizumab [extracellular region]
Hemostasis (Rattus norvegicus)
Cell surface interactions at the vascular wall (Rattus norvegicus)
ITGA4:ITGB1 binds natalizumab (Rattus norvegicus)
natalizumab [extracellular region]
ITGA4:ITGB1:natalizumab [plasma membrane] (Rattus norvegicus)
natalizumab [extracellular region]
Integrin alpha4beta1 binds JAM2:JAM3 (Rattus norvegicus)
ITGA4:ITGB1:natalizumab [plasma membrane] (Rattus norvegicus)
natalizumab [extracellular region]
Immune System (Rattus norvegicus)
Adaptive Immune System (Rattus norvegicus)
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Rattus norvegicus)
ITGA4:ITGB1 binds natalizumab (Rattus norvegicus)
natalizumab [extracellular region]
ITGA4:ITGB1:natalizumab [plasma membrane] (Rattus norvegicus)
natalizumab [extracellular region]
VCAM1 binds Integrin alpha4beta1 (Rattus norvegicus)
ITGA4:ITGB1:natalizumab [plasma membrane] (Rattus norvegicus)
natalizumab [extracellular region]
Extracellular matrix organization (Sus scrofa)
Integrin cell surface interactions (Sus scrofa)
ITGA4:ITGB1 binds natalizumab (Sus scrofa)
natalizumab [extracellular region]
ITGA4:ITGB1:natalizumab [plasma membrane] (Sus scrofa)
natalizumab [extracellular region]
Integrin alpha4beta1 binds JAM2:JAM3 (Sus scrofa)
ITGA4:ITGB1:natalizumab [plasma membrane] (Sus scrofa)
natalizumab [extracellular region]
VCAM1 binds Integrin alpha4beta1 (Sus scrofa)
ITGA4:ITGB1:natalizumab [plasma membrane] (Sus scrofa)
natalizumab [extracellular region]
Hemostasis (Sus scrofa)
Cell surface interactions at the vascular wall (Sus scrofa)
ITGA4:ITGB1 binds natalizumab (Sus scrofa)
natalizumab [extracellular region]
ITGA4:ITGB1:natalizumab [plasma membrane] (Sus scrofa)
natalizumab [extracellular region]
Integrin alpha4beta1 binds JAM2:JAM3 (Sus scrofa)
ITGA4:ITGB1:natalizumab [plasma membrane] (Sus scrofa)
natalizumab [extracellular region]
Immune System (Sus scrofa)
Adaptive Immune System (Sus scrofa)
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Sus scrofa)
ITGA4:ITGB1 binds natalizumab (Sus scrofa)
natalizumab [extracellular region]
ITGA4:ITGB1:natalizumab [plasma membrane] (Sus scrofa)
natalizumab [extracellular region]
VCAM1 binds Integrin alpha4beta1 (Sus scrofa)
ITGA4:ITGB1:natalizumab [plasma membrane] (Sus scrofa)
natalizumab [extracellular region]
Extracellular matrix organization (Xenopus tropicalis)
Integrin cell surface interactions (Xenopus tropicalis)
ITGA4:ITGB1 binds natalizumab (Xenopus tropicalis)
natalizumab [extracellular region]
ITGA4:ITGB1:natalizumab [plasma membrane] (Xenopus tropicalis)
natalizumab [extracellular region]
Integrin alpha4beta1 binds JAM2:JAM3 (Xenopus tropicalis)
ITGA4:ITGB1:natalizumab [plasma membrane] (Xenopus tropicalis)
natalizumab [extracellular region]
Hemostasis (Xenopus tropicalis)
Cell surface interactions at the vascular wall (Xenopus tropicalis)
ITGA4:ITGB1 binds natalizumab (Xenopus tropicalis)
natalizumab [extracellular region]
ITGA4:ITGB1:natalizumab [plasma membrane] (Xenopus tropicalis)
natalizumab [extracellular region]
Integrin alpha4beta1 binds JAM2:JAM3 (Xenopus tropicalis)
ITGA4:ITGB1:natalizumab [plasma membrane] (Xenopus tropicalis)
natalizumab [extracellular region]
Immune System (Xenopus tropicalis)
Adaptive Immune System (Xenopus tropicalis)
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Xenopus tropicalis)
ITGA4:ITGB1 binds natalizumab (Xenopus tropicalis)
natalizumab [extracellular region]
ITGA4:ITGB1:natalizumab [plasma membrane] (Xenopus tropicalis)
natalizumab [extracellular region]
External Reference Information
External Reference
natalizumab [Guide to Pharmacology:6591]
Participates
as an input of
ITGA4:ITGB1 binds natalizumab (Caenorhabditis elegans)
ITGA4:ITGB1 binds natalizumab (Gallus gallus)
ITGA4:ITGB1 binds natalizumab (Xenopus tropicalis)
ITGA4:ITGB1 binds natalizumab (Danio rerio)
ITGA4:ITGB1 binds natalizumab (Sus scrofa)
ITGA4:ITGB1 binds natalizumab (Bos taurus)
ITGA4:ITGB1 binds natalizumab (Canis familiaris)
ITGA4:ITGB1 binds natalizumab (Rattus norvegicus)
ITGA4:ITGB1 binds natalizumab (Mus musculus)
ITGA4:ITGB1 binds natalizumab (Homo sapiens)
ITGA4:ITGB1 binds natalizumab (Drosophila melanogaster)
as a component of
ITGA4:ITGB1:natalizumab [plasma membrane] (Gallus gallus)
ITGA4:ITGB1:natalizumab [plasma membrane] (Danio rerio)
ITGA4:ITGB1:natalizumab [plasma membrane] (Rattus norvegicus)
ITGA4:ITGB1:natalizumab [plasma membrane] (Xenopus tropicalis)
ITGA4:ITGB1:natalizumab [plasma membrane] (Sus scrofa)
ITGA4:ITGB1:natalizumab [plasma membrane] (Caenorhabditis elegans)
ITGA4:ITGB1:natalizumab [plasma membrane] (Mus musculus)
ITGA4:ITGB1:natalizumab [plasma membrane] (Bos taurus)
ITGA4:ITGB1:natalizumab [plasma membrane] (Canis familiaris)
ITGA4:ITGB1:natalizumab [plasma membrane] (Homo sapiens)
ITGA4:ITGB1:natalizumab [plasma membrane] (Drosophila melanogaster)
Disease
Name
Identifier
Synonyms
multiple sclerosis
DOID:2377
insular sclerosis, Generalized multiple sclerosis
Crohn's disease
DOID:8778
Crohn disease, Pediatric Crohn's disease, Granulomatous Colitis, Crohn's disease of large bowel, Crohn's disease of colon
Cross References
PubChem Compound
178103204
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