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HCQ [cytosol]
Stable Identifier
R-ALL-9678628
Type
ChemicalDrug
Compartment
cytosol
Synonyms
hydroxychloroquine, Dolquine®, Plaquenil®
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Canis familiaris
Gallus gallus
Mus musculus
Rattus norvegicus
Sus scrofa
Xenopus tropicalis
Expand all
Immune System (Bos taurus)
Innate Immune System (Bos taurus)
Toll-like Receptor Cascades (Bos taurus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Bos taurus)
C-ter TLR7 dimer binds HCQ (Bos taurus)
HCQ [cytosol]
C-ter TLR7 dimer:HCQ [endosome membrane] (Bos taurus)
HCQ [cytosol]
Toll Like Receptor 9 (TLR9) Cascade (Bos taurus)
C-ter TLR9 dimer binds HCQ (Bos taurus)
HCQ [cytosol]
C-ter TLR9 dimer:HCQ [endosome membrane] (Bos taurus)
HCQ [cytosol]
Engulfed CpG DNA binds to endosomal C-ter TLR9 (Bos taurus)
C-ter TLR9 dimer:HCQ [endosome membrane] (Bos taurus)
HCQ [cytosol]
Immune System (Canis familiaris)
Innate Immune System (Canis familiaris)
Toll-like Receptor Cascades (Canis familiaris)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Canis familiaris)
C-ter TLR7 dimer binds HCQ (Canis familiaris)
HCQ [cytosol]
C-ter TLR7 dimer:HCQ [endosome membrane] (Canis familiaris)
HCQ [cytosol]
Toll Like Receptor 9 (TLR9) Cascade (Canis familiaris)
C-ter TLR9 dimer binds HCQ (Canis familiaris)
HCQ [cytosol]
C-ter TLR9 dimer:HCQ [endosome membrane] (Canis familiaris)
HCQ [cytosol]
Engulfed CpG DNA binds to endosomal C-ter TLR9 (Canis familiaris)
C-ter TLR9 dimer:HCQ [endosome membrane] (Canis familiaris)
HCQ [cytosol]
Immune System (Gallus gallus)
Innate Immune System (Gallus gallus)
Toll-like Receptor Cascades (Gallus gallus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Gallus gallus)
C-ter TLR7 dimer binds HCQ (Gallus gallus)
HCQ [cytosol]
C-ter TLR7 dimer:HCQ [endosome membrane] (Gallus gallus)
HCQ [cytosol]
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
Respiratory Syncytial Virus Infection Pathway (Homo sapiens)
RSV-host interactions (Homo sapiens)
RSV ssRNA binds C-ter TLR7 dimer (Homo sapiens)
C-ter TLR7 dimer:HCQ [endosome membrane] (Homo sapiens)
HCQ [cytosol]
SARS-CoV Infections (Homo sapiens)
Potential therapeutics for SARS (Homo sapiens)
C-ter TLR7 dimer binds HCQ (Homo sapiens)
HCQ [cytosol]
C-ter TLR7 dimer:HCQ [endosome membrane] (Homo sapiens)
HCQ [cytosol]
C-ter TLR9 dimer binds HCQ (Homo sapiens)
HCQ [cytosol]
C-ter TLR9 dimer:HCQ [endosome membrane] (Homo sapiens)
HCQ [cytosol]
SARS-CoV-1 Infection (Homo sapiens)
Attachment and Entry (Homo sapiens)
CQ, HCQ diffuses from cytosol to endocytic vesicle lumen (Homo sapiens)
CQ, HCQ [cytosol]
HCQ [cytosol]
SARS-CoV-1-host interactions (Homo sapiens)
SARS-CoV-1 activates/modulates innate immune responses (Homo sapiens)
C-ter TLR7 dimer binds TLR7, TLR8 ligands (Homo sapiens)
C-ter TLR7 dimer:HCQ [endosome membrane] (Homo sapiens)
HCQ [cytosol]
SARS-CoV-2 Infection (Homo sapiens)
SARS-CoV-2-host interactions (Homo sapiens)
SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
C-ter TLR7 dimer binds SARS-CoV-2 GU-rich ssRNA (Homo sapiens)
C-ter TLR7 dimer:HCQ [endosome membrane] (Homo sapiens)
HCQ [cytosol]
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
C-ter TLR7 dimer binds HCQ (Homo sapiens)
HCQ [cytosol]
C-ter TLR7 dimer:HCQ [endosome membrane] (Homo sapiens)
HCQ [cytosol]
C-ter TLR7 dimer binds TLR7, TLR8 ligands (Homo sapiens)
C-ter TLR7 dimer:HCQ [endosome membrane] (Homo sapiens)
HCQ [cytosol]
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
C-ter TLR9 dimer binds HCQ (Homo sapiens)
HCQ [cytosol]
C-ter TLR9 dimer:HCQ [endosome membrane] (Homo sapiens)
HCQ [cytosol]
Engulfed CpG DNA binds to endosomal C-ter TLR9 (Homo sapiens)
C-ter TLR9 dimer:HCQ [endosome membrane] (Homo sapiens)
HCQ [cytosol]
Immune System (Mus musculus)
Innate Immune System (Mus musculus)
Toll-like Receptor Cascades (Mus musculus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Mus musculus)
C-ter TLR7 dimer binds HCQ (Mus musculus)
HCQ [cytosol]
C-ter TLR7 dimer:HCQ [endosome membrane] (Mus musculus)
HCQ [cytosol]
Toll Like Receptor 9 (TLR9) Cascade (Mus musculus)
C-ter TLR9 dimer binds HCQ (Mus musculus)
HCQ [cytosol]
C-ter TLR9 dimer:HCQ [endosome membrane] (Mus musculus)
HCQ [cytosol]
Engulfed CpG DNA binds to endosomal C-ter TLR9 (Mus musculus)
C-ter TLR9 dimer:HCQ [endosome membrane] (Mus musculus)
HCQ [cytosol]
Immune System (Rattus norvegicus)
Innate Immune System (Rattus norvegicus)
Toll-like Receptor Cascades (Rattus norvegicus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Rattus norvegicus)
C-ter TLR7 dimer binds HCQ (Rattus norvegicus)
HCQ [cytosol]
C-ter TLR7 dimer:HCQ [endosome membrane] (Rattus norvegicus)
HCQ [cytosol]
Toll Like Receptor 9 (TLR9) Cascade (Rattus norvegicus)
C-ter TLR9 dimer binds HCQ (Rattus norvegicus)
HCQ [cytosol]
C-ter TLR9 dimer:HCQ [endosome membrane] (Rattus norvegicus)
HCQ [cytosol]
Engulfed CpG DNA binds to endosomal C-ter TLR9 (Rattus norvegicus)
C-ter TLR9 dimer:HCQ [endosome membrane] (Rattus norvegicus)
HCQ [cytosol]
Immune System (Sus scrofa)
Innate Immune System (Sus scrofa)
Toll-like Receptor Cascades (Sus scrofa)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Sus scrofa)
C-ter TLR7 dimer binds HCQ (Sus scrofa)
HCQ [cytosol]
C-ter TLR7 dimer:HCQ [endosome membrane] (Sus scrofa)
HCQ [cytosol]
Toll Like Receptor 9 (TLR9) Cascade (Sus scrofa)
C-ter TLR9 dimer binds HCQ (Sus scrofa)
HCQ [cytosol]
C-ter TLR9 dimer:HCQ [endosome membrane] (Sus scrofa)
HCQ [cytosol]
Engulfed CpG DNA binds to endosomal C-ter TLR9 (Sus scrofa)
C-ter TLR9 dimer:HCQ [endosome membrane] (Sus scrofa)
HCQ [cytosol]
Immune System (Xenopus tropicalis)
Innate Immune System (Xenopus tropicalis)
Toll-like Receptor Cascades (Xenopus tropicalis)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Xenopus tropicalis)
C-ter TLR7 dimer binds HCQ (Xenopus tropicalis)
HCQ [cytosol]
C-ter TLR7 dimer:HCQ [endosome membrane] (Xenopus tropicalis)
HCQ [cytosol]
External Reference Information
External Reference
hydroxychloroquine [Guide to Pharmacology:7198]
Participates
as a member of
CQ, HCQ [cytosol]
as an input of
C-ter TLR9 dimer binds HCQ (Sus scrofa)
C-ter TLR9 dimer binds HCQ (Bos taurus)
C-ter TLR9 dimer binds HCQ (Rattus norvegicus)
C-ter TLR9 dimer binds HCQ (Mus musculus)
C-ter TLR9 dimer binds HCQ (Homo sapiens)
C-ter TLR9 dimer binds HCQ (Canis familiaris)
C-ter TLR7 dimer binds HCQ (Gallus gallus)
C-ter TLR7 dimer binds HCQ (Xenopus tropicalis)
C-ter TLR7 dimer binds HCQ (Sus scrofa)
C-ter TLR7 dimer binds HCQ (Bos taurus)
C-ter TLR7 dimer binds HCQ (Rattus norvegicus)
C-ter TLR7 dimer binds HCQ (Mus musculus)
C-ter TLR7 dimer binds HCQ (Homo sapiens)
C-ter TLR7 dimer binds HCQ (Canis familiaris)
as a component of
C-ter TLR9 dimer:HCQ [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:HCQ [endosome membrane] (Rattus norvegicus)
C-ter TLR9 dimer:HCQ [endosome membrane] (Mus musculus)
C-ter TLR9 dimer:HCQ [endosome membrane] (Sus scrofa)
C-ter TLR9 dimer:HCQ [endosome membrane] (Bos taurus)
C-ter TLR9 dimer:HCQ [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:HCQ [endosome membrane] (Xenopus tropicalis)
C-ter TLR7 dimer:HCQ [endosome membrane] (Bos taurus)
C-ter TLR7 dimer:HCQ [endosome membrane] (Canis familiaris)
C-ter TLR7 dimer:HCQ [endosome membrane] (Rattus norvegicus)
C-ter TLR7 dimer:HCQ [endosome membrane] (Mus musculus)
C-ter TLR7 dimer:HCQ [endosome membrane] (Sus scrofa)
C-ter TLR7 dimer:HCQ [endosome membrane] (Gallus gallus)
C-ter TLR7 dimer:HCQ [endosome membrane] (Homo sapiens)
Other forms of this molecule
HCQ [endocytic vesicle lumen]
Disease
Name
Identifier
Synonyms
malaria
DOID:12365
induced malaria
systemic lupus erythematosus
DOID:9074
Lupus Erythematosus, systemic, SLE - Lupus Erythematosus, systemic, disseminated lupus erythematosus
Cross References
Pharos - Ligands
DTMVCQWRY5XU
PubChem Compound
178103773
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