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cabozantinib [cytosol]
Stable Identifier
R-ALL-9669718
Type
ChemicalDrug
Compartment
cytosol
Synonyms
BMS907351, Cabometyx, Cometriq, XL184, XL-184
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Canis familiaris
Danio rerio
Mus musculus
Rattus norvegicus
Sus scrofa
Xenopus tropicalis
Expand all
Immune System (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
FLT3 Signaling (Bos taurus)
FLT3LG dimer:FLT3 dimer autophosphorylates (Bos taurus)
FLT3:FLT3-binding type II TKIs [plasma membrane] (Bos taurus)
type II FLT3-binding TKIs [cytosol]
cabozantinib [cytosol]
Signal Transduction (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by SCF-KIT (Bos taurus)
KIT binds type II TKIs (Bos taurus)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
KIT:type II TKIs [plasma membrane] (Bos taurus)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
Immune System (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
FLT3 Signaling (Canis familiaris)
FLT3LG dimer:FLT3 dimer autophosphorylates (Canis familiaris)
FLT3:FLT3-binding type II TKIs [plasma membrane] (Canis familiaris)
type II FLT3-binding TKIs [cytosol]
cabozantinib [cytosol]
Signal Transduction (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by SCF-KIT (Canis familiaris)
Autophosphorylation of KIT (Canis familiaris)
KIT:type II TKIs [plasma membrane] (Canis familiaris)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
KIT binds type II TKIs (Canis familiaris)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
KIT:type II TKIs [plasma membrane] (Canis familiaris)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
Signal Transduction (Danio rerio)
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by SCF-KIT (Danio rerio)
Autophosphorylation of KIT (Danio rerio)
KIT:type II TKIs [plasma membrane] (Danio rerio)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
KIT binds type II TKIs (Danio rerio)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
KIT:type II TKIs [plasma membrane] (Danio rerio)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
FLT3 signaling in disease (Homo sapiens)
FLT3 mutants bind TKIs (Homo sapiens)
FLT mutants bind type II TKIs (Homo sapiens)
type II FLT3-binding TKIs [cytosol]
cabozantinib [cytosol]
type II TKI-sensitive FLT3 mutants:type II TKIs [plasma membrane] (Homo sapiens)
type II FLT3-binding TKIs [cytosol]
cabozantinib [cytosol]
Signaling by KIT in disease (Homo sapiens)
KIT mutants bind TKIs (Homo sapiens)
KIT mutants bind type II TKIs (Homo sapiens)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
type II sensitive KIT mutants:type II TKIs [plasma membrane] (Homo sapiens)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
FLT3 Signaling (Homo sapiens)
FLT3 binds type II TKI (Homo sapiens)
type II FLT3-binding TKIs [cytosol]
cabozantinib [cytosol]
FLT3:FLT3-binding type II TKIs [plasma membrane] (Homo sapiens)
type II FLT3-binding TKIs [cytosol]
cabozantinib [cytosol]
FLT3LG dimer:FLT3 dimer autophosphorylates (Homo sapiens)
type II FLT3-binding TKIs [cytosol]
cabozantinib [cytosol]
FLT3:FLT3-binding type II TKIs [plasma membrane] (Homo sapiens)
type II FLT3-binding TKIs [cytosol]
cabozantinib [cytosol]
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by SCF-KIT (Homo sapiens)
Autophosphorylation of KIT (Homo sapiens)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
KIT:type II TKIs [plasma membrane] (Homo sapiens)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
KIT binds type II TKIs (Homo sapiens)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
KIT:type II TKIs [plasma membrane] (Homo sapiens)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
Immune System (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
FLT3 Signaling (Mus musculus)
FLT3LG dimer:FLT3 dimer autophosphorylates (Mus musculus)
FLT3:FLT3-binding type II TKIs [plasma membrane] (Mus musculus)
type II FLT3-binding TKIs [cytosol]
cabozantinib [cytosol]
Signal Transduction (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by SCF-KIT (Mus musculus)
Autophosphorylation of KIT (Mus musculus)
KIT:type II TKIs [plasma membrane] (Mus musculus)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
KIT binds type II TKIs (Mus musculus)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
KIT:type II TKIs [plasma membrane] (Mus musculus)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
Immune System (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
FLT3 Signaling (Rattus norvegicus)
FLT3LG dimer:FLT3 dimer autophosphorylates (Rattus norvegicus)
FLT3:FLT3-binding type II TKIs [plasma membrane] (Rattus norvegicus)
type II FLT3-binding TKIs [cytosol]
cabozantinib [cytosol]
Signal Transduction (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by SCF-KIT (Rattus norvegicus)
Autophosphorylation of KIT (Rattus norvegicus)
KIT:type II TKIs [plasma membrane] (Rattus norvegicus)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
KIT binds type II TKIs (Rattus norvegicus)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
KIT:type II TKIs [plasma membrane] (Rattus norvegicus)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
Signal Transduction (Sus scrofa)
Signaling by Receptor Tyrosine Kinases (Sus scrofa)
Signaling by SCF-KIT (Sus scrofa)
Autophosphorylation of KIT (Sus scrofa)
KIT:type II TKIs [plasma membrane] (Sus scrofa)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
KIT binds type II TKIs (Sus scrofa)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
KIT:type II TKIs [plasma membrane] (Sus scrofa)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
Signal Transduction (Xenopus tropicalis)
Signaling by Receptor Tyrosine Kinases (Xenopus tropicalis)
Signaling by SCF-KIT (Xenopus tropicalis)
KIT binds type II TKIs (Xenopus tropicalis)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
KIT:type II TKIs [plasma membrane] (Xenopus tropicalis)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
External Reference Information
External Reference
cabozantinib [IUPHAR:5887]
Participates
as a member of
type II FLT3-binding TKIs [cytosol]
type II KIT binding TKIs [cytosol]
Disease
Name
Identifier
Synonyms
cancer
DOID:162
malignant tumor, malignant neoplasm, primary cancer
Cross References
PharmacoDB
PDBC49172
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