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cabozantinib [cytosol]
Stable Identifier
R-ALL-9669718
Type
ChemicalDrug
Compartment
cytosol
Synonyms
BMS907351, Cabometyx, Cometriq, XL184, XL-184
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Drosophila melanogaster
Gallus gallus
Mus musculus
Rattus norvegicus
Sus scrofa
Xenopus tropicalis
Expand all
Immune System (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
FLT3 Signaling (Bos taurus)
FLT3LG dimer:FLT3 dimer autophosphorylates (Bos taurus)
FLT3:FLT3-binding type II TKIs [plasma membrane] (Bos taurus)
type II FLT3-binding TKIs [cytosol]
cabozantinib [cytosol]
Signal Transduction (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by MET (Bos taurus)
MET Receptor Activation (Bos taurus)
MET dimers autophosphorylate (Bos taurus)
HGF:MET dimer:TKIs [plasma membrane] (Bos taurus)
Anti-MET TKIs [cytosol]
cabozantinib [cytosol]
Negative regulation of MET activity (Bos taurus)
Drug-mediated inhibition of MET activation (Bos taurus)
Anti-MET small tyrosine kinase inhibitors bind MET (Bos taurus)
Anti-MET TKIs [cytosol]
cabozantinib [cytosol]
HGF:MET dimer:TKIs [plasma membrane] (Bos taurus)
Anti-MET TKIs [cytosol]
cabozantinib [cytosol]
Signaling by SCF-KIT (Bos taurus)
Autophosphorylation of KIT (Bos taurus)
KIT:type II TKIs [plasma membrane] (Bos taurus)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
KIT binds type II TKIs (Bos taurus)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
KIT:type II TKIs [plasma membrane] (Bos taurus)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
Signal Transduction (Caenorhabditis elegans)
Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by MET (Caenorhabditis elegans)
MET Receptor Activation (Caenorhabditis elegans)
MET dimers autophosphorylate (Caenorhabditis elegans)
HGF:MET dimer:TKIs [plasma membrane] (Caenorhabditis elegans)
Anti-MET TKIs [cytosol]
cabozantinib [cytosol]
Negative regulation of MET activity (Caenorhabditis elegans)
Drug-mediated inhibition of MET activation (Caenorhabditis elegans)
Anti-MET small tyrosine kinase inhibitors bind MET (Caenorhabditis elegans)
Anti-MET TKIs [cytosol]
cabozantinib [cytosol]
HGF:MET dimer:TKIs [plasma membrane] (Caenorhabditis elegans)
Anti-MET TKIs [cytosol]
cabozantinib [cytosol]
Signaling by SCF-KIT (Caenorhabditis elegans)
KIT binds type II TKIs (Caenorhabditis elegans)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
KIT:type II TKIs [plasma membrane] (Caenorhabditis elegans)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
Immune System (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
FLT3 Signaling (Canis familiaris)
FLT3LG dimer:FLT3 dimer autophosphorylates (Canis familiaris)
FLT3:FLT3-binding type II TKIs [plasma membrane] (Canis familiaris)
type II FLT3-binding TKIs [cytosol]
cabozantinib [cytosol]
Signal Transduction (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by MET (Canis familiaris)
MET Receptor Activation (Canis familiaris)
MET dimers autophosphorylate (Canis familiaris)
HGF:MET dimer:TKIs [plasma membrane] (Canis familiaris)
Anti-MET TKIs [cytosol]
cabozantinib [cytosol]
Negative regulation of MET activity (Canis familiaris)
Drug-mediated inhibition of MET activation (Canis familiaris)
Anti-MET small tyrosine kinase inhibitors bind MET (Canis familiaris)
Anti-MET TKIs [cytosol]
cabozantinib [cytosol]
HGF:MET dimer:TKIs [plasma membrane] (Canis familiaris)
Anti-MET TKIs [cytosol]
cabozantinib [cytosol]
Signaling by SCF-KIT (Canis familiaris)
Autophosphorylation of KIT (Canis familiaris)
KIT:type II TKIs [plasma membrane] (Canis familiaris)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
KIT binds type II TKIs (Canis familiaris)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
KIT:type II TKIs [plasma membrane] (Canis familiaris)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
Signal Transduction (Danio rerio)
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by SCF-KIT (Danio rerio)
Autophosphorylation of KIT (Danio rerio)
KIT:type II TKIs [plasma membrane] (Danio rerio)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
KIT binds type II TKIs (Danio rerio)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
KIT:type II TKIs [plasma membrane] (Danio rerio)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
Signal Transduction (Drosophila melanogaster)
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by SCF-KIT (Drosophila melanogaster)
KIT binds type II TKIs (Drosophila melanogaster)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
KIT:type II TKIs [plasma membrane] (Drosophila melanogaster)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
Signal Transduction (Gallus gallus)
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by MET (Gallus gallus)
MET Receptor Activation (Gallus gallus)
MET dimers autophosphorylate (Gallus gallus)
HGF:MET dimer:TKIs [plasma membrane] (Gallus gallus)
Anti-MET TKIs [cytosol]
cabozantinib [cytosol]
Negative regulation of MET activity (Gallus gallus)
Drug-mediated inhibition of MET activation (Gallus gallus)
Anti-MET small tyrosine kinase inhibitors bind MET (Gallus gallus)
Anti-MET TKIs [cytosol]
cabozantinib [cytosol]
HGF:MET dimer:TKIs [plasma membrane] (Gallus gallus)
Anti-MET TKIs [cytosol]
cabozantinib [cytosol]
Signaling by SCF-KIT (Gallus gallus)
Autophosphorylation of KIT (Gallus gallus)
KIT:type II TKIs [plasma membrane] (Gallus gallus)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
KIT binds type II TKIs (Gallus gallus)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
KIT:type II TKIs [plasma membrane] (Gallus gallus)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
FLT3 signaling in disease (Homo sapiens)
FLT3 mutants bind TKIs (Homo sapiens)
FLT mutants bind type II TKIs (Homo sapiens)
type II FLT3-binding TKIs [cytosol]
cabozantinib [cytosol]
type II TKI-sensitive FLT3 mutants:type II TKIs [plasma membrane] (Homo sapiens)
type II FLT3-binding TKIs [cytosol]
cabozantinib [cytosol]
Signaling by KIT in disease (Homo sapiens)
KIT mutants bind TKIs (Homo sapiens)
KIT mutants bind type II TKIs (Homo sapiens)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
type II sensitive KIT mutants:type II TKIs [plasma membrane] (Homo sapiens)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
FLT3 Signaling (Homo sapiens)
FLT3 binds type II TKI (Homo sapiens)
type II FLT3-binding TKIs [cytosol]
cabozantinib [cytosol]
FLT3:FLT3-binding type II TKIs [plasma membrane] (Homo sapiens)
type II FLT3-binding TKIs [cytosol]
cabozantinib [cytosol]
FLT3LG dimer:FLT3 dimer autophosphorylates (Homo sapiens)
type II FLT3-binding TKIs [cytosol]
cabozantinib [cytosol]
FLT3:FLT3-binding type II TKIs [plasma membrane] (Homo sapiens)
type II FLT3-binding TKIs [cytosol]
cabozantinib [cytosol]
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by MET (Homo sapiens)
MET Receptor Activation (Homo sapiens)
MET dimers autophosphorylate (Homo sapiens)
Anti-MET TKIs [cytosol]
cabozantinib [cytosol]
HGF:MET dimer:TKIs [plasma membrane] (Homo sapiens)
Anti-MET TKIs [cytosol]
cabozantinib [cytosol]
Negative regulation of MET activity (Homo sapiens)
Drug-mediated inhibition of MET activation (Homo sapiens)
Anti-MET small tyrosine kinase inhibitors bind MET (Homo sapiens)
Anti-MET TKIs [cytosol]
cabozantinib [cytosol]
HGF:MET dimer:TKIs [plasma membrane] (Homo sapiens)
Anti-MET TKIs [cytosol]
cabozantinib [cytosol]
Signaling by SCF-KIT (Homo sapiens)
Autophosphorylation of KIT (Homo sapiens)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
KIT:type II TKIs [plasma membrane] (Homo sapiens)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
KIT binds type II TKIs (Homo sapiens)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
KIT:type II TKIs [plasma membrane] (Homo sapiens)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
Immune System (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
FLT3 Signaling (Mus musculus)
FLT3LG dimer:FLT3 dimer autophosphorylates (Mus musculus)
FLT3:FLT3-binding type II TKIs [plasma membrane] (Mus musculus)
type II FLT3-binding TKIs [cytosol]
cabozantinib [cytosol]
Signal Transduction (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by MET (Mus musculus)
MET Receptor Activation (Mus musculus)
MET dimers autophosphorylate (Mus musculus)
HGF:MET dimer:TKIs [plasma membrane] (Mus musculus)
Anti-MET TKIs [cytosol]
cabozantinib [cytosol]
Negative regulation of MET activity (Mus musculus)
Drug-mediated inhibition of MET activation (Mus musculus)
Anti-MET small tyrosine kinase inhibitors bind MET (Mus musculus)
Anti-MET TKIs [cytosol]
cabozantinib [cytosol]
HGF:MET dimer:TKIs [plasma membrane] (Mus musculus)
Anti-MET TKIs [cytosol]
cabozantinib [cytosol]
Signaling by SCF-KIT (Mus musculus)
Autophosphorylation of KIT (Mus musculus)
KIT:type II TKIs [plasma membrane] (Mus musculus)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
KIT binds type II TKIs (Mus musculus)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
KIT:type II TKIs [plasma membrane] (Mus musculus)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
Signal Transduction (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by MET (Rattus norvegicus)
MET Receptor Activation (Rattus norvegicus)
MET dimers autophosphorylate (Rattus norvegicus)
HGF:MET dimer:TKIs [plasma membrane] (Rattus norvegicus)
Anti-MET TKIs [cytosol]
cabozantinib [cytosol]
Negative regulation of MET activity (Rattus norvegicus)
Drug-mediated inhibition of MET activation (Rattus norvegicus)
Anti-MET small tyrosine kinase inhibitors bind MET (Rattus norvegicus)
Anti-MET TKIs [cytosol]
cabozantinib [cytosol]
HGF:MET dimer:TKIs [plasma membrane] (Rattus norvegicus)
Anti-MET TKIs [cytosol]
cabozantinib [cytosol]
Signaling by SCF-KIT (Rattus norvegicus)
Autophosphorylation of KIT (Rattus norvegicus)
KIT:type II TKIs [plasma membrane] (Rattus norvegicus)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
KIT binds type II TKIs (Rattus norvegicus)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
KIT:type II TKIs [plasma membrane] (Rattus norvegicus)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
Immune System (Sus scrofa)
Cytokine Signaling in Immune system (Sus scrofa)
FLT3 Signaling (Sus scrofa)
FLT3LG dimer:FLT3 dimer autophosphorylates (Sus scrofa)
FLT3:FLT3-binding type II TKIs [plasma membrane] (Sus scrofa)
type II FLT3-binding TKIs [cytosol]
cabozantinib [cytosol]
Signal Transduction (Sus scrofa)
Signaling by Receptor Tyrosine Kinases (Sus scrofa)
Signaling by MET (Sus scrofa)
MET Receptor Activation (Sus scrofa)
MET dimers autophosphorylate (Sus scrofa)
HGF:MET dimer:TKIs [plasma membrane] (Sus scrofa)
Anti-MET TKIs [cytosol]
cabozantinib [cytosol]
Negative regulation of MET activity (Sus scrofa)
Drug-mediated inhibition of MET activation (Sus scrofa)
Anti-MET small tyrosine kinase inhibitors bind MET (Sus scrofa)
Anti-MET TKIs [cytosol]
cabozantinib [cytosol]
HGF:MET dimer:TKIs [plasma membrane] (Sus scrofa)
Anti-MET TKIs [cytosol]
cabozantinib [cytosol]
Signaling by SCF-KIT (Sus scrofa)
Autophosphorylation of KIT (Sus scrofa)
KIT:type II TKIs [plasma membrane] (Sus scrofa)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
KIT binds type II TKIs (Sus scrofa)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
KIT:type II TKIs [plasma membrane] (Sus scrofa)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
Signal Transduction (Xenopus tropicalis)
Signaling by Receptor Tyrosine Kinases (Xenopus tropicalis)
Signaling by MET (Xenopus tropicalis)
MET Receptor Activation (Xenopus tropicalis)
MET dimers autophosphorylate (Xenopus tropicalis)
HGF:MET dimer:TKIs [plasma membrane] (Xenopus tropicalis)
Anti-MET TKIs [cytosol]
cabozantinib [cytosol]
Negative regulation of MET activity (Xenopus tropicalis)
Drug-mediated inhibition of MET activation (Xenopus tropicalis)
Anti-MET small tyrosine kinase inhibitors bind MET (Xenopus tropicalis)
Anti-MET TKIs [cytosol]
cabozantinib [cytosol]
HGF:MET dimer:TKIs [plasma membrane] (Xenopus tropicalis)
Anti-MET TKIs [cytosol]
cabozantinib [cytosol]
Signaling by SCF-KIT (Xenopus tropicalis)
Autophosphorylation of KIT (Xenopus tropicalis)
KIT:type II TKIs [plasma membrane] (Xenopus tropicalis)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
KIT binds type II TKIs (Xenopus tropicalis)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
KIT:type II TKIs [plasma membrane] (Xenopus tropicalis)
type II KIT binding TKIs [cytosol]
cabozantinib [cytosol]
External Reference Information
External Reference
cabozantinib [Guide to Pharmacology:5887]
Participates
as a member of
type II FLT3-binding TKIs [cytosol]
Anti-MET TKIs [cytosol]
type II KIT binding TKIs [cytosol]
Disease
Name
Identifier
Synonyms
cancer
DOID:162
malignant tumor, malignant neoplasm, primary cancer
Cross References
ChEBI
72317
Pharos - Ligands
LB6JCCMPSY9Z
PharmacoDB
PDBC02008
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