SCH772984 [cytosol]

Stable Identifier
R-ALL-9657543
Type
ChemicalDrug
Compartment
cytosol
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Literature References
PubMed ID Title Journal Year
25195011 A unique inhibitor binding site in ERK1/2 is associated with slow binding kinetics

Liang, Y, Knapp, S, Chaikuad, A, Tacconi, EM, Zimmer, J, Gray, NS, Tarsounas, M

Nat. Chem. Biol. 2014
23614898 Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors

Liu, J, Fawell, S, Angagaw, MH, Paliwal, S, Zawel, L, Desai, J, Jha, S, Pinheiro, EM, Zhang, L, Dayananth, P, Restaino, CR, Hicklin, D, Shipps, G, Jayaraman, L, Morris, EJ, Zhu, H, Samatar, AA, Babu, BS, Witter, D, Long, B, Cooper, A, Windsor, W, Siliphaivanh, P, Xiao, L, Pelletier, MR, Zhang, R, Gilliland, DG, Zhu, L, Zhao, S, Philippar, U, Hruza, A, Deng, Y, Kelly, J, Wang, J, Kirschmeier, P, Dinunzio, E, Daublain, P, Black, S, Jin, W, Carr, D, Lutterbach, BA, Gao, X, Bishop, WR

Cancer Discov 2013
25313996 Discovery of novel, dual mechanism ERK inhibitors by affinity selection screening of an inactive kinase

English, JM, Nan, Y, Dayananth, P, Zhu, HY, Chuang, CC, Windsor, WT, Annis, DA, Hruza, AW, Samatar, AA, Wang, T, Kirschmeier, P, Cooper, A, Jin, W, Shipps, GW, Carr, D, Deng, Y, Xiao, L

J. Med. Chem. 2014
External Reference Information
External Reference
SCH772984 [Guide to Pharmacology:8056]
Participates
as a candidate of
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
ChEBI
PharmacoDB
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