Reactome | refametinib [cytosol]

refametinib [cytosol]

Stable Identifier

R-ALL-9657517

Type

ChemicalDrug

Compartment

cytosol

Locations in the PathwayBrowser

for Species:

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Signal Transduction (Bos taurus)

- MAPK family signaling cascades (Bos taurus)
  - MAPK1/MAPK3 signaling (Bos taurus)
    - RAF/MAP kinase cascade (Bos taurus)
      - MAP2K and MAPK activation (Bos taurus)
        
        MAP2Ks phosphorylate MAPKs (Bos taurus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        refametinib [cytosol]
        
        Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Bos taurus)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        refametinib [cytosol]
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        refametinib [cytosol]

Signal Transduction (Caenorhabditis elegans)

- MAPK family signaling cascades (Caenorhabditis elegans)
  - MAPK1/MAPK3 signaling (Caenorhabditis elegans)
    - RAF/MAP kinase cascade (Caenorhabditis elegans)
      - MAP2K and MAPK activation (Caenorhabditis elegans)
        
        MAP2Ks phosphorylate MAPKs (Caenorhabditis elegans)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        refametinib [cytosol]
        
        Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Caenorhabditis elegans)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        refametinib [cytosol]
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        refametinib [cytosol]

Signal Transduction (Canis familiaris)

- MAPK family signaling cascades (Canis familiaris)
  - MAPK1/MAPK3 signaling (Canis familiaris)
    - RAF/MAP kinase cascade (Canis familiaris)
      - MAP2K and MAPK activation (Canis familiaris)
        
        MAP2Ks phosphorylate MAPKs (Canis familiaris)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        refametinib [cytosol]
        
        Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Canis familiaris)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        refametinib [cytosol]
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        refametinib [cytosol]

Signal Transduction (Drosophila melanogaster)

- MAPK family signaling cascades (Drosophila melanogaster)
  - MAPK1/MAPK3 signaling (Drosophila melanogaster)
    - RAF/MAP kinase cascade (Drosophila melanogaster)
      - MAP2K and MAPK activation (Drosophila melanogaster)
        
        MAP2Ks phosphorylate MAPKs (Drosophila melanogaster)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        refametinib [cytosol]
        
        Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Drosophila melanogaster)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        refametinib [cytosol]
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        refametinib [cytosol]

Signal Transduction (Gallus gallus)

- MAPK family signaling cascades (Gallus gallus)
  - MAPK1/MAPK3 signaling (Gallus gallus)
    - RAF/MAP kinase cascade (Gallus gallus)
      - MAP2K and MAPK activation (Gallus gallus)
        
        MAP2Ks phosphorylate MAPKs (Gallus gallus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        refametinib [cytosol]
        
        Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Gallus gallus)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        refametinib [cytosol]
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        refametinib [cytosol]

Signal Transduction (Homo sapiens)

- MAPK family signaling cascades (Homo sapiens)
  - MAPK1/MAPK3 signaling (Homo sapiens)
    - RAF/MAP kinase cascade (Homo sapiens)
      - MAP2K and MAPK activation (Homo sapiens)
        
        MAP2Ks phosphorylate MAPKs (Homo sapiens)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        refametinib [cytosol]
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        refametinib [cytosol]
        
        Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Homo sapiens)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        refametinib [cytosol]
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        refametinib [cytosol]

Signal Transduction (Mus musculus)

- MAPK family signaling cascades (Mus musculus)
  - MAPK1/MAPK3 signaling (Mus musculus)
    - RAF/MAP kinase cascade (Mus musculus)
      - MAP2K and MAPK activation (Mus musculus)
        
        MAP2Ks phosphorylate MAPKs (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        refametinib [cytosol]
        
        Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Mus musculus)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        refametinib [cytosol]
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        refametinib [cytosol]

Signal Transduction (Rattus norvegicus)

- MAPK family signaling cascades (Rattus norvegicus)
  - MAPK1/MAPK3 signaling (Rattus norvegicus)
    - RAF/MAP kinase cascade (Rattus norvegicus)
      - MAP2K and MAPK activation (Rattus norvegicus)
        
        MAP2Ks phosphorylate MAPKs (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        refametinib [cytosol]
        
        Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Rattus norvegicus)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        refametinib [cytosol]
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        refametinib [cytosol]

Signal Transduction (Sus scrofa)

- MAPK family signaling cascades (Sus scrofa)
  - MAPK1/MAPK3 signaling (Sus scrofa)
    - RAF/MAP kinase cascade (Sus scrofa)
      - MAP2K and MAPK activation (Sus scrofa)
        
        MAP2Ks phosphorylate MAPKs (Sus scrofa)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Sus scrofa)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        refametinib [cytosol]
        
        Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Sus scrofa)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        refametinib [cytosol]
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Sus scrofa)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        refametinib [cytosol]

Literature References

PubMed ID	Title	Journal	Year
19706763	RDEA119/BAY 869766: a potent, selective, allosteric inhibitor of MEK1/2 for the treatment of cancer Vernier, JM, Appleby, T, Vo, T, Yeh, LT, Miner, JN, Weingarten, P, Iverson, C, Lai, C, Larson, G, Dadson, C, Quart, B, Maderna, A, Hamatake, R	Cancer Res.	2009

External Reference Information

External Reference

refametinib [Guide to Pharmacology:7942]

Participates

as a candidate of

single mechanism MAP2K1/2 inhibitors [cytosol]

Disease

Name	Identifier	Synonyms
cancer	DOID:162	malignant tumor, malignant neoplasm, primary cancer

Cross References

ChEBI

231602

PharmacoDB

PDBC00014

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