Reactome | ulixertinib [cytosol]

ulixertinib [cytosol]

Stable Identifier

R-ALL-9657506

Type

ChemicalDrug

Compartment

cytosol

Locations in the PathwayBrowser

for Species:

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Signal Transduction (Bos taurus)

- MAPK family signaling cascades (Bos taurus)
  - MAPK1/MAPK3 signaling (Bos taurus)
    - RAF/MAP kinase cascade (Bos taurus)
      - MAP2K and MAPK activation (Bos taurus)
        
        Single mechanism MAPK inhibitors bind phosphorylated MAPK (Bos taurus)
        
        single mechanism MAPK inhibitors [cytosol]
        
        ulixertinib [cytosol]
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Bos taurus)
        
        single mechanism MAPK inhibitors [cytosol]
        
        ulixertinib [cytosol]

Signal Transduction (Caenorhabditis elegans)

- MAPK family signaling cascades (Caenorhabditis elegans)
  - MAPK1/MAPK3 signaling (Caenorhabditis elegans)
    - RAF/MAP kinase cascade (Caenorhabditis elegans)
      - MAP2K and MAPK activation (Caenorhabditis elegans)
        
        Single mechanism MAPK inhibitors bind phosphorylated MAPK (Caenorhabditis elegans)
        
        single mechanism MAPK inhibitors [cytosol]
        
        ulixertinib [cytosol]
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Caenorhabditis elegans)
        
        single mechanism MAPK inhibitors [cytosol]
        
        ulixertinib [cytosol]

Signal Transduction (Canis familiaris)

- MAPK family signaling cascades (Canis familiaris)
  - MAPK1/MAPK3 signaling (Canis familiaris)
    - RAF/MAP kinase cascade (Canis familiaris)
      - MAP2K and MAPK activation (Canis familiaris)
        
        Single mechanism MAPK inhibitors bind phosphorylated MAPK (Canis familiaris)
        
        single mechanism MAPK inhibitors [cytosol]
        
        ulixertinib [cytosol]
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Canis familiaris)
        
        single mechanism MAPK inhibitors [cytosol]
        
        ulixertinib [cytosol]

Signal Transduction (Drosophila melanogaster)

- MAPK family signaling cascades (Drosophila melanogaster)
  - MAPK1/MAPK3 signaling (Drosophila melanogaster)
    - RAF/MAP kinase cascade (Drosophila melanogaster)
      - MAP2K and MAPK activation (Drosophila melanogaster)
        
        Single mechanism MAPK inhibitors bind phosphorylated MAPK (Drosophila melanogaster)
        
        single mechanism MAPK inhibitors [cytosol]
        
        ulixertinib [cytosol]
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Drosophila melanogaster)
        
        single mechanism MAPK inhibitors [cytosol]
        
        ulixertinib [cytosol]

Signal Transduction (Gallus gallus)

- MAPK family signaling cascades (Gallus gallus)
  - MAPK1/MAPK3 signaling (Gallus gallus)
    - RAF/MAP kinase cascade (Gallus gallus)
      - MAP2K and MAPK activation (Gallus gallus)
        
        Single mechanism MAPK inhibitors bind phosphorylated MAPK (Gallus gallus)
        
        single mechanism MAPK inhibitors [cytosol]
        
        ulixertinib [cytosol]
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Gallus gallus)
        
        single mechanism MAPK inhibitors [cytosol]
        
        ulixertinib [cytosol]

Signal Transduction (Homo sapiens)

- MAPK family signaling cascades (Homo sapiens)
  - MAPK1/MAPK3 signaling (Homo sapiens)
    - RAF/MAP kinase cascade (Homo sapiens)
      - MAP2K and MAPK activation (Homo sapiens)
        
        Single mechanism MAPK inhibitors bind phosphorylated MAPK (Homo sapiens)
        
        single mechanism MAPK inhibitors [cytosol]
        
        ulixertinib [cytosol]
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
        
        single mechanism MAPK inhibitors [cytosol]
        
        ulixertinib [cytosol]

Signal Transduction (Mus musculus)

- MAPK family signaling cascades (Mus musculus)
  - MAPK1/MAPK3 signaling (Mus musculus)
    - RAF/MAP kinase cascade (Mus musculus)
      - MAP2K and MAPK activation (Mus musculus)
        
        Single mechanism MAPK inhibitors bind phosphorylated MAPK (Mus musculus)
        
        single mechanism MAPK inhibitors [cytosol]
        
        ulixertinib [cytosol]
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Mus musculus)
        
        single mechanism MAPK inhibitors [cytosol]
        
        ulixertinib [cytosol]

Signal Transduction (Rattus norvegicus)

- MAPK family signaling cascades (Rattus norvegicus)
  - MAPK1/MAPK3 signaling (Rattus norvegicus)
    - RAF/MAP kinase cascade (Rattus norvegicus)
      - MAP2K and MAPK activation (Rattus norvegicus)
        
        Single mechanism MAPK inhibitors bind phosphorylated MAPK (Rattus norvegicus)
        
        single mechanism MAPK inhibitors [cytosol]
        
        ulixertinib [cytosol]
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Rattus norvegicus)
        
        single mechanism MAPK inhibitors [cytosol]
        
        ulixertinib [cytosol]

Signal Transduction (Sus scrofa)

- MAPK family signaling cascades (Sus scrofa)
  - MAPK1/MAPK3 signaling (Sus scrofa)
    - RAF/MAP kinase cascade (Sus scrofa)
      - MAP2K and MAPK activation (Sus scrofa)
        
        Single mechanism MAPK inhibitors bind phosphorylated MAPK (Sus scrofa)
        
        single mechanism MAPK inhibitors [cytosol]
        
        ulixertinib [cytosol]
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Sus scrofa)
        
        single mechanism MAPK inhibitors [cytosol]
        
        ulixertinib [cytosol]

Literature References

PubMed ID	Title	Journal	Year
28939558	Targeting the MAPK Signaling Pathway in Cancer: Promising Preclinical Activity with the Novel Selective ERK1/2 Inhibitor BVD-523 (Ulixertinib) Namchuk, M, Germann, UA, Roix, JJ, Shapiro, P, Hoover, RR, Meshaw, K, Fitzgibbon, M, Emery, CM, Samadani, R, Furey, BF, Markland, W, Aronov, AM, Saha, S, Martinez-Botella, G, DeCrescenzo, G, Sorrell, DA, Wick, MJ, Hale, M, Groover, A, Welsch, DJ, Boucher, DM	Mol. Cancer Ther.	2017

External Reference Information

External Reference

ulixertinib [Guide to Pharmacology:9210]

Participates

as a candidate of

single mechanism MAPK inhibitors [cytosol]

Disease

Name	Identifier	Synonyms
cancer	DOID:162	malignant tumor, malignant neoplasm, primary cancer

Cross References

PharmacoDB

PDBC02316

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