Reactome | losartan [extracellular region]

Stable Identifier

R-ALL-9615293

Type

ChemicalDrug

Compartment

extracellular region

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
7717281	Safety and tolerability of losartan potassium, an angiotensin II receptor antagonist, compared with hydrochlorothiazide, atenolol, felodipine ER, and angiotensin-converting enzyme inhibitors for the treatment of systemic hypertension Goldberg, AI, Dunlay, MC, Sweet, CS	Am. J. Cardiol.	1995
19922995	Effects of high-dose versus low-dose losartan on clinical outcomes in patients with heart failure (HEAAL study): a randomised, double-blind trial Konstam, MA, Neaton, JD, Dickstein, K, Drexler, H, Komajda, M, Martinez, FA, Riegger, GA, Malbecq, W, Smith, RD, Guptha, S, Poole-Wilson, PA	Lancet	2009
14749145	Losartan and other angiotensin II antagonists for nephropathy in type 2 diabetes mellitus: a review of the clinical trial evidence Ruilope, LM, Segura, J	Clin Ther	2003

External Reference Information

External Reference

losartan [Guide to Pharmacology:590]

Participates

as a member of

Disease

Name	Identifier	Synonyms
kidney disease	DOID:557	nephropathy
hypertension	DOID:10763	High blood pressure (& [essential hypertension]), HTN, hypertensive disease, hyperpiesia, vascular hypertensive disorder
congestive heart failure	DOID:6000	CHF, Cardiac Failure Congestive, Weak heart, Congestive heart disease

Cross References

Mondo

0005044, 0005009, 0005240

ChEBI

6541, 6541

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