Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Cu2+ [plasma membrane]
Stable Identifier
R-ALL-904823
Type
Chemical Compound [SimpleEntity]
Compartment
plasma membrane
Synonyms
Copper, copper atom
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Gallus gallus
Mus musculus
Rattus norvegicus
Sus scrofa
Xenopus tropicalis
Expand all
Metabolism (Bos taurus)
Biological oxidations (Bos taurus)
Phase I - Functionalization of compounds (Bos taurus)
AOC1 deaminates Hist (Bos taurus)
AOC1 dimer:2xCu2+:4xCa2+ [plasma membrane] (Bos taurus)
Cu2+ [plasma membrane]
AOC3 deaminates BZAM (Bos taurus)
AOC3 dimer:2xCu2+:4xCa2+ [plasma membrane] (Bos taurus)
Cu2+ [plasma membrane]
Transport of small molecules (Bos taurus)
Iron uptake and transport (Bos taurus)
SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Bos taurus)
SLC40A1:HEPH:6Cu2+ [plasma membrane] (Bos taurus)
Cu2+ [plasma membrane]
SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Bos taurus)
SLC40A1:HEPH:6Cu2+ [plasma membrane] (Bos taurus)
Cu2+ [plasma membrane]
SLC-mediated transmembrane transport (Bos taurus)
Metal ion SLC transporters (Bos taurus)
SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Bos taurus)
SLC40A1:HEPH:6Cu2+ [plasma membrane] (Bos taurus)
Cu2+ [plasma membrane]
Transport of small molecules (Caenorhabditis elegans)
Iron uptake and transport (Caenorhabditis elegans)
SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Caenorhabditis elegans)
SLC40A1:HEPH:6Cu2+ [plasma membrane] (Caenorhabditis elegans)
Cu2+ [plasma membrane]
SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Caenorhabditis elegans)
SLC40A1:HEPH:6Cu2+ [plasma membrane] (Caenorhabditis elegans)
Cu2+ [plasma membrane]
SLC-mediated transmembrane transport (Caenorhabditis elegans)
Metal ion SLC transporters (Caenorhabditis elegans)
SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Caenorhabditis elegans)
SLC40A1:HEPH:6Cu2+ [plasma membrane] (Caenorhabditis elegans)
Cu2+ [plasma membrane]
Metabolism (Canis familiaris)
Biological oxidations (Canis familiaris)
Phase I - Functionalization of compounds (Canis familiaris)
AOC3 deaminates BZAM (Canis familiaris)
AOC3 dimer:2xCu2+:4xCa2+ [plasma membrane] (Canis familiaris)
Cu2+ [plasma membrane]
Transport of small molecules (Canis familiaris)
Iron uptake and transport (Canis familiaris)
SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Canis familiaris)
SLC40A1:HEPH:6Cu2+ [plasma membrane] (Canis familiaris)
Cu2+ [plasma membrane]
SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Canis familiaris)
SLC40A1:HEPH:6Cu2+ [plasma membrane] (Canis familiaris)
Cu2+ [plasma membrane]
SLC-mediated transmembrane transport (Canis familiaris)
Metal ion SLC transporters (Canis familiaris)
SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Canis familiaris)
SLC40A1:HEPH:6Cu2+ [plasma membrane] (Canis familiaris)
Cu2+ [plasma membrane]
Metabolism (Danio rerio)
Biological oxidations (Danio rerio)
Phase I - Functionalization of compounds (Danio rerio)
AOC1 deaminates Hist (Danio rerio)
AOC1 dimer:2xCu2+:4xCa2+ [plasma membrane] (Danio rerio)
Cu2+ [plasma membrane]
Transport of small molecules (Danio rerio)
Iron uptake and transport (Danio rerio)
SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Danio rerio)
SLC40A1:HEPH:6Cu2+ [plasma membrane] (Danio rerio)
Cu2+ [plasma membrane]
SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Danio rerio)
SLC40A1:HEPH:6Cu2+ [plasma membrane] (Danio rerio)
Cu2+ [plasma membrane]
SLC-mediated transmembrane transport (Danio rerio)
Metal ion SLC transporters (Danio rerio)
SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Danio rerio)
SLC40A1:HEPH:6Cu2+ [plasma membrane] (Danio rerio)
Cu2+ [plasma membrane]
Metabolism (Gallus gallus)
Biological oxidations (Gallus gallus)
Phase I - Functionalization of compounds (Gallus gallus)
AOC1 deaminates Hist (Gallus gallus)
AOC1 dimer:2xCu2+:4xCa2+ [plasma membrane] (Gallus gallus)
Cu2+ [plasma membrane]
AOC3 deaminates BZAM (Gallus gallus)
AOC3 dimer:2xCu2+:4xCa2+ [plasma membrane] (Gallus gallus)
Cu2+ [plasma membrane]
Transport of small molecules (Gallus gallus)
Iron uptake and transport (Gallus gallus)
SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Gallus gallus)
SLC40A1:HEPH:6Cu2+ [plasma membrane] (Gallus gallus)
Cu2+ [plasma membrane]
SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Gallus gallus)
SLC40A1:HEPH:6Cu2+ [plasma membrane] (Gallus gallus)
Cu2+ [plasma membrane]
SLC-mediated transmembrane transport (Gallus gallus)
Metal ion SLC transporters (Gallus gallus)
SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Gallus gallus)
SLC40A1:HEPH:6Cu2+ [plasma membrane] (Gallus gallus)
Cu2+ [plasma membrane]
Disease (Homo sapiens)
Disorders of transmembrane transporters (Homo sapiens)
SLC transporter disorders (Homo sapiens)
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) (Homo sapiens)
Defective SLC40A1 does not transport Fe3+ from extracellular region to cytosol (Homo sapiens)
HEPH:6xCu2+:SLC40A1 mutants [plasma membrane] (Homo sapiens)
Cu2+ [plasma membrane]
Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Phase I - Functionalization of compounds (Homo sapiens)
AOC1 deaminates Hist (Homo sapiens)
AOC1 dimer:2xCu2+:4xCa2+ [plasma membrane] (Homo sapiens)
Cu2+ [plasma membrane]
AOC3 deaminates BZAM (Homo sapiens)
AOC3 dimer:2xCu2+:4xCa2+ [plasma membrane] (Homo sapiens)
Cu2+ [plasma membrane]
Transport of small molecules (Homo sapiens)
Iron uptake and transport (Homo sapiens)
SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Homo sapiens)
SLC40A1:HEPH:6Cu2+ [plasma membrane] (Homo sapiens)
Cu2+ [plasma membrane]
SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Homo sapiens)
SLC40A1:HEPH:6Cu2+ [plasma membrane] (Homo sapiens)
Cu2+ [plasma membrane]
SLC-mediated transmembrane transport (Homo sapiens)
Metal ion SLC transporters (Homo sapiens)
SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Homo sapiens)
SLC40A1:HEPH:6Cu2+ [plasma membrane] (Homo sapiens)
Cu2+ [plasma membrane]
Metabolism (Mus musculus)
Biological oxidations (Mus musculus)
Phase I - Functionalization of compounds (Mus musculus)
AOC1 deaminates Hist (Mus musculus)
AOC1 dimer:2xCu2+:4xCa2+ [plasma membrane] (Mus musculus)
Cu2+ [plasma membrane]
AOC3 deaminates BZAM (Mus musculus)
AOC3 dimer:2xCu2+:4xCa2+ [plasma membrane] (Mus musculus)
Cu2+ [plasma membrane]
Transport of small molecules (Mus musculus)
Iron uptake and transport (Mus musculus)
SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Mus musculus)
SLC40A1:HEPH:6Cu2+ [plasma membrane] (Mus musculus)
Cu2+ [plasma membrane]
SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Mus musculus)
SLC40A1:HEPH:6Cu2+ [plasma membrane] (Mus musculus)
Cu2+ [plasma membrane]
SLC-mediated transmembrane transport (Mus musculus)
Metal ion SLC transporters (Mus musculus)
SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Mus musculus)
SLC40A1:HEPH:6Cu2+ [plasma membrane] (Mus musculus)
Cu2+ [plasma membrane]
Metabolism (Rattus norvegicus)
Biological oxidations (Rattus norvegicus)
Phase I - Functionalization of compounds (Rattus norvegicus)
AOC1 deaminates Hist (Rattus norvegicus)
AOC1 dimer:2xCu2+:4xCa2+ [plasma membrane] (Rattus norvegicus)
Cu2+ [plasma membrane]
AOC3 deaminates BZAM (Rattus norvegicus)
AOC3 dimer:2xCu2+:4xCa2+ [plasma membrane] (Rattus norvegicus)
Cu2+ [plasma membrane]
Transport of small molecules (Rattus norvegicus)
Iron uptake and transport (Rattus norvegicus)
SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Rattus norvegicus)
SLC40A1:HEPH:6Cu2+ [plasma membrane] (Rattus norvegicus)
Cu2+ [plasma membrane]
SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Rattus norvegicus)
SLC40A1:HEPH:6Cu2+ [plasma membrane] (Rattus norvegicus)
Cu2+ [plasma membrane]
SLC-mediated transmembrane transport (Rattus norvegicus)
Metal ion SLC transporters (Rattus norvegicus)
SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Rattus norvegicus)
SLC40A1:HEPH:6Cu2+ [plasma membrane] (Rattus norvegicus)
Cu2+ [plasma membrane]
Metabolism (Sus scrofa)
Biological oxidations (Sus scrofa)
Phase I - Functionalization of compounds (Sus scrofa)
AOC3 deaminates BZAM (Sus scrofa)
AOC3 dimer:2xCu2+:4xCa2+ [plasma membrane] (Sus scrofa)
Cu2+ [plasma membrane]
Transport of small molecules (Sus scrofa)
Iron uptake and transport (Sus scrofa)
SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Sus scrofa)
SLC40A1:HEPH:6Cu2+ [plasma membrane] (Sus scrofa)
Cu2+ [plasma membrane]
SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Sus scrofa)
SLC40A1:HEPH:6Cu2+ [plasma membrane] (Sus scrofa)
Cu2+ [plasma membrane]
SLC-mediated transmembrane transport (Sus scrofa)
Metal ion SLC transporters (Sus scrofa)
SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Sus scrofa)
SLC40A1:HEPH:6Cu2+ [plasma membrane] (Sus scrofa)
Cu2+ [plasma membrane]
Metabolism (Xenopus tropicalis)
Biological oxidations (Xenopus tropicalis)
Phase I - Functionalization of compounds (Xenopus tropicalis)
AOC1 deaminates Hist (Xenopus tropicalis)
AOC1 dimer:2xCu2+:4xCa2+ [plasma membrane] (Xenopus tropicalis)
Cu2+ [plasma membrane]
AOC3 deaminates BZAM (Xenopus tropicalis)
AOC3 dimer:2xCu2+:4xCa2+ [plasma membrane] (Xenopus tropicalis)
Cu2+ [plasma membrane]
Transport of small molecules (Xenopus tropicalis)
Iron uptake and transport (Xenopus tropicalis)
SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Xenopus tropicalis)
SLC40A1:HEPH:6Cu2+ [plasma membrane] (Xenopus tropicalis)
Cu2+ [plasma membrane]
SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Xenopus tropicalis)
SLC40A1:HEPH:6Cu2+ [plasma membrane] (Xenopus tropicalis)
Cu2+ [plasma membrane]
SLC-mediated transmembrane transport (Xenopus tropicalis)
Metal ion SLC transporters (Xenopus tropicalis)
SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Xenopus tropicalis)
SLC40A1:HEPH:6Cu2+ [plasma membrane] (Xenopus tropicalis)
Cu2+ [plasma membrane]
External Reference Information
External Reference
copper atom [ChEBI:28694]
Participates
as a component of
HEPH:6xCu2+:SLC40A1 mutants [plasma membrane] (Homo sapiens)
AOC1 dimer:2xCu2+:4xCa2+ [plasma membrane] (Mus musculus)
AOC1 dimer:2xCu2+:4xCa2+ [plasma membrane] (Bos taurus)
AOC1 dimer:2xCu2+:4xCa2+ [plasma membrane] (Danio rerio)
AOC1 dimer:2xCu2+:4xCa2+ [plasma membrane] (Gallus gallus)
AOC1 dimer:2xCu2+:4xCa2+ [plasma membrane] (Rattus norvegicus)
AOC1 dimer:2xCu2+:4xCa2+ [plasma membrane] (Xenopus tropicalis)
AOC1 dimer:2xCu2+:4xCa2+ [plasma membrane] (Homo sapiens)
AOC3 dimer:2xCu2+:4xCa2+ [plasma membrane] (Sus scrofa)
AOC3 dimer:2xCu2+:4xCa2+ [plasma membrane] (Xenopus tropicalis)
AOC3 dimer:2xCu2+:4xCa2+ [plasma membrane] (Gallus gallus)
AOC3 dimer:2xCu2+:4xCa2+ [plasma membrane] (Bos taurus)
AOC3 dimer:2xCu2+:4xCa2+ [plasma membrane] (Rattus norvegicus)
AOC3 dimer:2xCu2+:4xCa2+ [plasma membrane] (Canis familiaris)
AOC3 dimer:2xCu2+:4xCa2+ [plasma membrane] (Mus musculus)
AOC3 dimer:2xCu2+:4xCa2+ [plasma membrane] (Homo sapiens)
SLC40A1:HEPH:6Cu2+ [plasma membrane] (Bos taurus)
SLC40A1:HEPH:6Cu2+ [plasma membrane] (Gallus gallus)
SLC40A1:HEPH:6Cu2+ [plasma membrane] (Rattus norvegicus)
SLC40A1:HEPH:6Cu2+ [plasma membrane] (Mus musculus)
SLC40A1:HEPH:6Cu2+ [plasma membrane] (Sus scrofa)
SLC40A1:HEPH:6Cu2+ [plasma membrane] (Xenopus tropicalis)
SLC40A1:HEPH:6Cu2+ [plasma membrane] (Canis familiaris)
SLC40A1:HEPH:6Cu2+ [plasma membrane] (Caenorhabditis elegans)
SLC40A1:HEPH:6Cu2+ [plasma membrane] (Danio rerio)
SLC40A1:HEPH:6Cu2+ [plasma membrane] (Homo sapiens)
Other forms of this molecule
Cu2+ [secretory granule lumen]
Cross References
COMPOUND
C00070
PubChem Substance
8144302
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text