dicumarol [cytosol]

Stable Identifier
R-ALL-9035047
Type
ChemicalDrug
Compartment
cytosol
Synonyms
dicoumarol
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General
Dicumarol is a naturally-occurring anticoagulant that binds to and inhibits VKORC1 (Hollman 1991). It is a derivative of coumarin, a bitter, sweet smelling substance made by plants that can be transformed into dicumarol by fungi. It became the prototype of the 4-hydroxycoumarin anticoagulant drug class but has since (1950s) been replaced by its simpler derivative warfarin, and other 4-hydroxycoumarin drugs (Gomez-Outes et al. 2012).
Literature References
PubMed ID Title Journal Year
25639072 [On the history of vitamin K, dicoumarol and warfarin]

Permin, H, Kruse, PR, Norn, S, Kruse, E

Dan Medicinhist Arbog 2014
External Reference Information
External Reference
dicumarol [Guide to Pharmacology:6808]
Participates
as a member of
Disease
Name Identifier Synonyms
pulmonary embolism DOID:9477 pulmonary embolus, pulmonary artery embolism
Cross References
ChEBI
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