phenindione [cytosol]

Stable Identifier
R-ALL-9035044
Type
ChemicalDrug
Compartment
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General

The oral anticoagulant drug phenindione binds to and inhibits VKORC1, acting in a similar way to warfarin (Field et al. 1952). However, phenindione can be associated with hypersensitivity reactions so is rarely used (Naisbitt et al. 2005).

Literature References
PubMed ID Title Journal Year
15743920 Characterization of the T-cell response in a patient with phenindione hypersensitivity

Naisbitt, DJ, Farrell, J, Chamberlain, PJ, Hopkins, JE, Berry, NG, Pirmohamed, M, Park, BK

J. Pharmacol. Exp. Ther. 2005
External Reference Information
External Reference
Participates
Disease
Name Identifier Synonyms
pulmonary embolism DOID:9477 pulmonary embolus, pulmonary artery embolism
Cross References
ChEBI
PharmacoDB
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