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What is Reactome ?
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Digital Preservation
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DCA [mitochondrial matrix]
Stable Identifier
R-ALL-9010792
Type
ChemicalDrug
Compartment
mitochondrial matrix
Synonyms
dichloroacetic acid, dichloroacetate, dicholoroacetic acid
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Rattus norvegicus
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Metabolism (Bos taurus)
Aerobic respiration and respiratory electron transport (Bos taurus)
Pyruvate metabolism (Bos taurus)
Regulation of pyruvate metabolism (Bos taurus)
Regulation of pyruvate dehydrogenase (PDH) complex (Bos taurus)
DCA binds PDK2 (Bos taurus)
DCA [mitochondrial matrix]
DCA:PDK2 [mitochondrial matrix] (Bos taurus)
DCA [mitochondrial matrix]
GSTZ1 dimer dehalogenates DCA (Bos taurus)
DCA [mitochondrial matrix]
PDK isozymes phosphorylate PDHC subunit E1 (Bos taurus)
DCA:PDK2 [mitochondrial matrix] (Bos taurus)
DCA [mitochondrial matrix]
Signal Transduction (Bos taurus)
Signaling by Nuclear Receptors (Bos taurus)
Signaling by Retinoic Acid (Bos taurus)
PDK isozymes phosphorylate PDHC subunit E1 (Bos taurus)
DCA:PDK2 [mitochondrial matrix] (Bos taurus)
DCA [mitochondrial matrix]
Metabolism (Caenorhabditis elegans)
Aerobic respiration and respiratory electron transport (Caenorhabditis elegans)
Pyruvate metabolism (Caenorhabditis elegans)
Regulation of pyruvate metabolism (Caenorhabditis elegans)
Regulation of pyruvate dehydrogenase (PDH) complex (Caenorhabditis elegans)
DCA binds PDK2 (Caenorhabditis elegans)
DCA [mitochondrial matrix]
DCA:PDK2 [mitochondrial matrix] (Caenorhabditis elegans)
DCA [mitochondrial matrix]
GSTZ1 dimer dehalogenates DCA (Caenorhabditis elegans)
DCA [mitochondrial matrix]
PDK isozymes phosphorylate PDHC subunit E1 (Caenorhabditis elegans)
DCA:PDK2 [mitochondrial matrix] (Caenorhabditis elegans)
DCA [mitochondrial matrix]
Signal Transduction (Caenorhabditis elegans)
Signaling by Nuclear Receptors (Caenorhabditis elegans)
Signaling by Retinoic Acid (Caenorhabditis elegans)
PDK isozymes phosphorylate PDHC subunit E1 (Caenorhabditis elegans)
DCA:PDK2 [mitochondrial matrix] (Caenorhabditis elegans)
DCA [mitochondrial matrix]
Metabolism (Canis familiaris)
Aerobic respiration and respiratory electron transport (Canis familiaris)
Pyruvate metabolism (Canis familiaris)
Regulation of pyruvate metabolism (Canis familiaris)
Regulation of pyruvate dehydrogenase (PDH) complex (Canis familiaris)
DCA binds PDK2 (Canis familiaris)
DCA [mitochondrial matrix]
DCA:PDK2 [mitochondrial matrix] (Canis familiaris)
DCA [mitochondrial matrix]
GSTZ1 dimer dehalogenates DCA (Canis familiaris)
DCA [mitochondrial matrix]
PDK isozymes phosphorylate PDHC subunit E1 (Canis familiaris)
DCA:PDK2 [mitochondrial matrix] (Canis familiaris)
DCA [mitochondrial matrix]
Signal Transduction (Canis familiaris)
Signaling by Nuclear Receptors (Canis familiaris)
Signaling by Retinoic Acid (Canis familiaris)
PDK isozymes phosphorylate PDHC subunit E1 (Canis familiaris)
DCA:PDK2 [mitochondrial matrix] (Canis familiaris)
DCA [mitochondrial matrix]
Metabolism (Danio rerio)
Aerobic respiration and respiratory electron transport (Danio rerio)
Pyruvate metabolism (Danio rerio)
Regulation of pyruvate metabolism (Danio rerio)
Regulation of pyruvate dehydrogenase (PDH) complex (Danio rerio)
DCA binds PDK2 (Danio rerio)
DCA [mitochondrial matrix]
DCA:PDK2 [mitochondrial matrix] (Danio rerio)
DCA [mitochondrial matrix]
GSTZ1 dimer dehalogenates DCA (Danio rerio)
DCA [mitochondrial matrix]
Metabolism (Dictyostelium discoideum)
Aerobic respiration and respiratory electron transport (Dictyostelium discoideum)
Pyruvate metabolism (Dictyostelium discoideum)
Regulation of pyruvate metabolism (Dictyostelium discoideum)
Regulation of pyruvate dehydrogenase (PDH) complex (Dictyostelium discoideum)
GSTZ1 dimer dehalogenates DCA (Dictyostelium discoideum)
DCA [mitochondrial matrix]
Metabolism (Drosophila melanogaster)
Aerobic respiration and respiratory electron transport (Drosophila melanogaster)
Pyruvate metabolism (Drosophila melanogaster)
Regulation of pyruvate metabolism (Drosophila melanogaster)
Regulation of pyruvate dehydrogenase (PDH) complex (Drosophila melanogaster)
DCA binds PDK2 (Drosophila melanogaster)
DCA [mitochondrial matrix]
DCA:PDK2 [mitochondrial matrix] (Drosophila melanogaster)
DCA [mitochondrial matrix]
GSTZ1 dimer dehalogenates DCA (Drosophila melanogaster)
DCA [mitochondrial matrix]
PDK isozymes phosphorylate PDHC subunit E1 (Drosophila melanogaster)
DCA:PDK2 [mitochondrial matrix] (Drosophila melanogaster)
DCA [mitochondrial matrix]
Signal Transduction (Drosophila melanogaster)
Signaling by Nuclear Receptors (Drosophila melanogaster)
Signaling by Retinoic Acid (Drosophila melanogaster)
PDK isozymes phosphorylate PDHC subunit E1 (Drosophila melanogaster)
DCA:PDK2 [mitochondrial matrix] (Drosophila melanogaster)
DCA [mitochondrial matrix]
Metabolism (Gallus gallus)
Aerobic respiration and respiratory electron transport (Gallus gallus)
Pyruvate metabolism (Gallus gallus)
Regulation of pyruvate metabolism (Gallus gallus)
Regulation of pyruvate dehydrogenase (PDH) complex (Gallus gallus)
DCA binds PDK2 (Gallus gallus)
DCA [mitochondrial matrix]
DCA:PDK2 [mitochondrial matrix] (Gallus gallus)
DCA [mitochondrial matrix]
GSTZ1 dimer dehalogenates DCA (Gallus gallus)
DCA [mitochondrial matrix]
PDK isozymes phosphorylate PDHC subunit E1 (Gallus gallus)
DCA:PDK2 [mitochondrial matrix] (Gallus gallus)
DCA [mitochondrial matrix]
Signal Transduction (Gallus gallus)
Signaling by Nuclear Receptors (Gallus gallus)
Signaling by Retinoic Acid (Gallus gallus)
PDK isozymes phosphorylate PDHC subunit E1 (Gallus gallus)
DCA:PDK2 [mitochondrial matrix] (Gallus gallus)
DCA [mitochondrial matrix]
Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Pyruvate metabolism (Homo sapiens)
Regulation of pyruvate metabolism (Homo sapiens)
Regulation of pyruvate dehydrogenase (PDH) complex (Homo sapiens)
DCA binds PDK2 (Homo sapiens)
DCA [mitochondrial matrix]
DCA:PDK2 [mitochondrial matrix] (Homo sapiens)
DCA [mitochondrial matrix]
GSTZ1 dimer dehalogenates DCA (Homo sapiens)
DCA [mitochondrial matrix]
PDK isozymes phosphorylate PDHC subunit E1 (Homo sapiens)
DCA:PDK2 [mitochondrial matrix] (Homo sapiens)
DCA [mitochondrial matrix]
Signal Transduction (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
Signaling by Retinoic Acid (Homo sapiens)
PDK isozymes phosphorylate PDHC subunit E1 (Homo sapiens)
DCA:PDK2 [mitochondrial matrix] (Homo sapiens)
DCA [mitochondrial matrix]
Metabolism (Mus musculus)
Aerobic respiration and respiratory electron transport (Mus musculus)
Pyruvate metabolism (Mus musculus)
Regulation of pyruvate metabolism (Mus musculus)
Regulation of pyruvate dehydrogenase (PDH) complex (Mus musculus)
DCA binds PDK2 (Mus musculus)
DCA [mitochondrial matrix]
DCA:PDK2 [mitochondrial matrix] (Mus musculus)
DCA [mitochondrial matrix]
GSTZ1 dimer dehalogenates DCA (Mus musculus)
DCA [mitochondrial matrix]
PDK isozymes phosphorylate PDHC subunit E1 (Mus musculus)
DCA:PDK2 [mitochondrial matrix] (Mus musculus)
DCA [mitochondrial matrix]
Signal Transduction (Mus musculus)
Signaling by Nuclear Receptors (Mus musculus)
Signaling by Retinoic Acid (Mus musculus)
PDK isozymes phosphorylate PDHC subunit E1 (Mus musculus)
DCA:PDK2 [mitochondrial matrix] (Mus musculus)
DCA [mitochondrial matrix]
Metabolism (Rattus norvegicus)
Aerobic respiration and respiratory electron transport (Rattus norvegicus)
Pyruvate metabolism (Rattus norvegicus)
Regulation of pyruvate metabolism (Rattus norvegicus)
Regulation of pyruvate dehydrogenase (PDH) complex (Rattus norvegicus)
DCA binds PDK2 (Rattus norvegicus)
DCA [mitochondrial matrix]
DCA:PDK2 [mitochondrial matrix] (Rattus norvegicus)
DCA [mitochondrial matrix]
GSTZ1 dimer dehalogenates DCA (Rattus norvegicus)
DCA [mitochondrial matrix]
PDK isozymes phosphorylate PDHC subunit E1 (Rattus norvegicus)
DCA:PDK2 [mitochondrial matrix] (Rattus norvegicus)
DCA [mitochondrial matrix]
Signal Transduction (Rattus norvegicus)
Signaling by Nuclear Receptors (Rattus norvegicus)
Signaling by Retinoic Acid (Rattus norvegicus)
PDK isozymes phosphorylate PDHC subunit E1 (Rattus norvegicus)
DCA:PDK2 [mitochondrial matrix] (Rattus norvegicus)
DCA [mitochondrial matrix]
Metabolism (Schizosaccharomyces pombe)
Aerobic respiration and respiratory electron transport (Schizosaccharomyces pombe)
Pyruvate metabolism (Schizosaccharomyces pombe)
Regulation of pyruvate metabolism (Schizosaccharomyces pombe)
Regulation of pyruvate dehydrogenase (PDH) complex (Schizosaccharomyces pombe)
DCA binds PDK2 (Schizosaccharomyces pombe)
DCA [mitochondrial matrix]
DCA:PDK2 [mitochondrial matrix] (Schizosaccharomyces pombe)
DCA [mitochondrial matrix]
PDK isozymes phosphorylate PDHC subunit E1 (Schizosaccharomyces pombe)
DCA:PDK2 [mitochondrial matrix] (Schizosaccharomyces pombe)
DCA [mitochondrial matrix]
Signal Transduction (Schizosaccharomyces pombe)
Signaling by Nuclear Receptors (Schizosaccharomyces pombe)
Signaling by Retinoic Acid (Schizosaccharomyces pombe)
PDK isozymes phosphorylate PDHC subunit E1 (Schizosaccharomyces pombe)
DCA:PDK2 [mitochondrial matrix] (Schizosaccharomyces pombe)
DCA [mitochondrial matrix]
Metabolism (Sus scrofa)
Aerobic respiration and respiratory electron transport (Sus scrofa)
Pyruvate metabolism (Sus scrofa)
Regulation of pyruvate metabolism (Sus scrofa)
Regulation of pyruvate dehydrogenase (PDH) complex (Sus scrofa)
DCA binds PDK2 (Sus scrofa)
DCA [mitochondrial matrix]
DCA:PDK2 [mitochondrial matrix] (Sus scrofa)
DCA [mitochondrial matrix]
GSTZ1 dimer dehalogenates DCA (Sus scrofa)
DCA [mitochondrial matrix]
PDK isozymes phosphorylate PDHC subunit E1 (Sus scrofa)
DCA:PDK2 [mitochondrial matrix] (Sus scrofa)
DCA [mitochondrial matrix]
Signal Transduction (Sus scrofa)
Signaling by Nuclear Receptors (Sus scrofa)
Signaling by Retinoic Acid (Sus scrofa)
PDK isozymes phosphorylate PDHC subunit E1 (Sus scrofa)
DCA:PDK2 [mitochondrial matrix] (Sus scrofa)
DCA [mitochondrial matrix]
Metabolism (Xenopus tropicalis)
Aerobic respiration and respiratory electron transport (Xenopus tropicalis)
Pyruvate metabolism (Xenopus tropicalis)
Regulation of pyruvate metabolism (Xenopus tropicalis)
Regulation of pyruvate dehydrogenase (PDH) complex (Xenopus tropicalis)
DCA binds PDK2 (Xenopus tropicalis)
DCA [mitochondrial matrix]
DCA:PDK2 [mitochondrial matrix] (Xenopus tropicalis)
DCA [mitochondrial matrix]
GSTZ1 dimer dehalogenates DCA (Xenopus tropicalis)
DCA [mitochondrial matrix]
PDK isozymes phosphorylate PDHC subunit E1 (Xenopus tropicalis)
DCA:PDK2 [mitochondrial matrix] (Xenopus tropicalis)
DCA [mitochondrial matrix]
Signal Transduction (Xenopus tropicalis)
Signaling by Nuclear Receptors (Xenopus tropicalis)
Signaling by Retinoic Acid (Xenopus tropicalis)
PDK isozymes phosphorylate PDHC subunit E1 (Xenopus tropicalis)
DCA:PDK2 [mitochondrial matrix] (Xenopus tropicalis)
DCA [mitochondrial matrix]
Literature References
PubMed ID
Title
Journal
Year
17544412
Amino acid residues responsible for the recognition of dichloroacetate by pyruvate dehydrogenase kinase 2
Tuganova, A
,
Klyuyeva, A
,
Popov, KM
FEBS Lett.
2007
19833728
Pivotal role of the C-terminal DW-motif in mediating inhibition of pyruvate dehydrogenase kinase 2 by dichloroacetate
Li, J
,
Chuang, DT
,
Kato, M
J. Biol. Chem.
2009
External Reference Information
External Reference
dichloroacetate [Guide to Pharmacology:4518]
Participates
as an input of
DCA binds PDK2 (Schizosaccharomyces pombe)
DCA binds PDK2 (Caenorhabditis elegans)
DCA binds PDK2 (Drosophila melanogaster)
DCA binds PDK2 (Gallus gallus)
DCA binds PDK2 (Xenopus tropicalis)
DCA binds PDK2 (Danio rerio)
DCA binds PDK2 (Sus scrofa)
DCA binds PDK2 (Bos taurus)
DCA binds PDK2 (Canis familiaris)
DCA binds PDK2 (Rattus norvegicus)
DCA binds PDK2 (Mus musculus)
DCA binds PDK2 (Homo sapiens)
GSTZ1 dimer dehalogenates DCA (Dictyostelium discoideum)
GSTZ1 dimer dehalogenates DCA (Caenorhabditis elegans)
GSTZ1 dimer dehalogenates DCA (Drosophila melanogaster)
GSTZ1 dimer dehalogenates DCA (Gallus gallus)
GSTZ1 dimer dehalogenates DCA (Xenopus tropicalis)
GSTZ1 dimer dehalogenates DCA (Danio rerio)
GSTZ1 dimer dehalogenates DCA (Sus scrofa)
GSTZ1 dimer dehalogenates DCA (Bos taurus)
GSTZ1 dimer dehalogenates DCA (Canis familiaris)
GSTZ1 dimer dehalogenates DCA (Rattus norvegicus)
GSTZ1 dimer dehalogenates DCA (Mus musculus)
GSTZ1 dimer dehalogenates DCA (Homo sapiens)
as a component of
DCA:PDK2 [mitochondrial matrix] (Gallus gallus)
DCA:PDK2 [mitochondrial matrix] (Sus scrofa)
DCA:PDK2 [mitochondrial matrix] (Canis familiaris)
DCA:PDK2 [mitochondrial matrix] (Danio rerio)
DCA:PDK2 [mitochondrial matrix] (Caenorhabditis elegans)
DCA:PDK2 [mitochondrial matrix] (Rattus norvegicus)
DCA:PDK2 [mitochondrial matrix] (Mus musculus)
DCA:PDK2 [mitochondrial matrix] (Schizosaccharomyces pombe)
DCA:PDK2 [mitochondrial matrix] (Xenopus tropicalis)
DCA:PDK2 [mitochondrial matrix] (Bos taurus)
DCA:PDK2 [mitochondrial matrix] (Homo sapiens)
DCA:PDK2 [mitochondrial matrix] (Drosophila melanogaster)
Disease
Name
Identifier
Synonyms
lactic acidosis
DOID:3650
cancer
DOID:162
malignant tumor, malignant neoplasm, primary cancer
Cross References
ChEBI
28240
PharmacoDB
PDBC02868
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