NLRP3 elicitor small molecules [cytosol]

Stable Identifier
Set [DefinedSet]
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Several intact viruses, fungi and bacteria can induce NLRP3 activation, as can human proteins such as beta-amyloid (Schroder & Tschopp 2010).

Literature References
PubMed ID Title Journal Year
19258328 NLRP3/cryopyrin is necessary for interleukin-1beta (IL-1beta) release in response to hyaluronan, an endogenous trigger of inflammation in response to injury

Yamasaki, K, Muto, J, Taylor, KR, Cogen, AL, Audish, D, Bertin, J, Grant, EP, Coyle, AJ, Misaghi, A, Hoffman, HM, Gallo, RL

J Biol Chem 2009
18604209 The NALP3 inflammasome is involved in the innate immune response to amyloid-beta

Halle, A, Hornung, V, Petzold, GC, Stewart, CR, Monks, BG, Reinheckel, T, Fitzgerald, KA, Latz, E, Moore, KJ, Golenbock, DT

Nat Immunol 2008
18577586 The Nalp3 inflammasome is essential for the development of silicosis

Cassel, SL, Eisenbarth, SC, Iyer, SS, Sadler, JJ, Colegio, OR, Tephly, LA, Carter, AB, Rothman, PB, Flavell, RA, Sutterwala, FS

Proc Natl Acad Sci U S A 2008
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