mRNA Transcript Targeted by HuR Phosphorylated on Ser221 and Ser318 [nucleoplasm]

Stable Identifier
R-ALL-517622
Type
OtherEntity
Compartment
nucleoplasm
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General
Phosphorylated HuR (phosphoserine221 and phosphoserine318) binds AU-rich elements in the following mRNAs: Cyclooxygenase-2 (COX-2, PTGS2), Cyclin A (CCNA, CCNA2), and Cyclin D1 (CCND1).
Literature References
PubMed ID Title Journal Year
20086103 Tandem phosphorylation of serine 221 and 318 by PKC{delta} coordinates mRNA binding and nucleo-cytoplasmic shuttling of HuR

Pfeilschifter, J, Doller, A, Schwalbe, H, Schlepckow, K, Eberhardt, W

Mol Cell Biol 2010
18285462 Posttranslational modification of the AU-rich element binding protein HuR by protein kinase Cdelta elicits angiotensin II-induced stabilization and nuclear export of cyclooxygenase 2 mRNA

Pfeilschifter, J, Müller, R, Doller, A, Huwiler, A, Akool, el-S, Eberhardt, W, Radeke, HH

Mol Cell Biol 2008
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