Reactome | NAGLY [extracellular region]

NAGLY [extracellular region]

Stable Identifier

R-ALL-517533

Type

Chemical Compound [SimpleEntity]

Compartment

extracellular region

Synonyms

N-arachidonyl glycine, N-arachidonoylglycine

Locations in the PathwayBrowser

for Species:

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Signal Transduction (Canis familiaris)

- Signaling by GPCR (Canis familiaris)
  - GPCR downstream signalling (Canis familiaris)
    - G alpha (i) signalling events (Canis familiaris)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        GPR18:NAGLY [plasma membrane] (Canis familiaris)
        
        NAGLY [extracellular region]
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        GPR18:NAGLY [plasma membrane] (Canis familiaris)
        
        NAGLY [extracellular region]
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        GPR18:NAGLY [plasma membrane] (Canis familiaris)
        
        NAGLY [extracellular region]
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        GPR18:NAGLY [plasma membrane] (Canis familiaris)
        
        NAGLY [extracellular region]
      - The Ligand:GPCR:Gi complex dissociates (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        GPR18:NAGLY [plasma membrane] (Canis familiaris)
        
        NAGLY [extracellular region]
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        GPR18:NAGLY [plasma membrane] (Canis familiaris)
        
        NAGLY [extracellular region]
  - GPCR ligand binding (Canis familiaris)
    - Class A/1 (Rhodopsin-like receptors) (Canis familiaris)
      - N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Canis familiaris)
        
        NAGLY [extracellular region]
        
        GPR18:NAGLY [plasma membrane] (Canis familiaris)
        
        NAGLY [extracellular region]

Signal Transduction (Rattus norvegicus)

- Signaling by GPCR (Rattus norvegicus)
  - GPCR downstream signalling (Rattus norvegicus)
    - G alpha (i) signalling events (Rattus norvegicus)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Rattus norvegicus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Rattus norvegicus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Rattus norvegicus)
        
        GPR18:NAGLY [plasma membrane] (Rattus norvegicus)
        
        NAGLY [extracellular region]
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Rattus norvegicus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Rattus norvegicus)
        
        GPR18:NAGLY [plasma membrane] (Rattus norvegicus)
        
        NAGLY [extracellular region]
  - GPCR ligand binding (Rattus norvegicus)
    - Class A/1 (Rhodopsin-like receptors) (Rattus norvegicus)
      - N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Rattus norvegicus)
        
        NAGLY [extracellular region]
        
        GPR18:NAGLY [plasma membrane] (Rattus norvegicus)
        
        NAGLY [extracellular region]

Signal Transduction (Xenopus tropicalis)

- Signaling by GPCR (Xenopus tropicalis)
  - GPCR downstream signalling (Xenopus tropicalis)
    - G alpha (i) signalling events (Xenopus tropicalis)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Xenopus tropicalis)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Xenopus tropicalis)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Xenopus tropicalis)
        
        GPR18:NAGLY [plasma membrane] (Xenopus tropicalis)
        
        NAGLY [extracellular region]
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Xenopus tropicalis)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Xenopus tropicalis)
        
        GPR18:NAGLY [plasma membrane] (Xenopus tropicalis)
        
        NAGLY [extracellular region]
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Xenopus tropicalis)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Xenopus tropicalis)
        
        GPR18:NAGLY [plasma membrane] (Xenopus tropicalis)
        
        NAGLY [extracellular region]
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Xenopus tropicalis)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Xenopus tropicalis)
        
        GPR18:NAGLY [plasma membrane] (Xenopus tropicalis)
        
        NAGLY [extracellular region]
      - The Ligand:GPCR:Gi complex dissociates (Xenopus tropicalis)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Xenopus tropicalis)
        
        GPR18:NAGLY [plasma membrane] (Xenopus tropicalis)
        
        NAGLY [extracellular region]
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Xenopus tropicalis)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Xenopus tropicalis)
        
        GPR18:NAGLY [plasma membrane] (Xenopus tropicalis)
        
        NAGLY [extracellular region]
  - GPCR ligand binding (Xenopus tropicalis)
    - Class A/1 (Rhodopsin-like receptors) (Xenopus tropicalis)
      - N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Xenopus tropicalis)
        
        NAGLY [extracellular region]
        
        GPR18:NAGLY [plasma membrane] (Xenopus tropicalis)
        
        NAGLY [extracellular region]

External Reference Information

External Reference

N-arachidonoylglycine [ChEBI:58961]

Participates

as an input of

as a component of

Cross References

Guide to Pharmacology - Ligands

3635

HMDB Metabolite

HMDB0005096

ZINC

ZINC000004467867

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