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About
What is Reactome ?
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Release Calendar
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Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
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Table of Contents
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Reactome Research Spotlight
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COVID-19 Disease Pathways
Docs
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How do I search ?
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Analysis Tools
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Cu2+ [extracellular region]
Stable Identifier
R-ALL-437295
Type
Chemical Compound [SimpleEntity]
Compartment
extracellular region
Synonyms
Copper, copper(2+)
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Cellular responses to stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
Cellular response to chemical stress (Bos taurus)
Detoxification of Reactive Oxygen Species (Bos taurus)
SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Bos taurus)
SOD3 tetramer [extracellular region] (Bos taurus)
SOD3:Cu2+:Zn2+ [extracellular region] (Bos taurus)
Cu2+ [extracellular region]
Secretion of SOD3 (Bos taurus)
SOD3 tetramer [extracellular region] (Bos taurus)
SOD3:Cu2+:Zn2+ [extracellular region] (Bos taurus)
Cu2+ [extracellular region]
Extracellular matrix organization (Bos taurus)
Collagen formation (Bos taurus)
Assembly of collagen fibrils and other multimeric structures (Bos taurus)
Crosslinking of collagen fibrils (Bos taurus)
Formation of allysine by LOX (Bos taurus)
Lysyl oxidases:Cu2+ [extracellular region] (Bos taurus)
Cu2+ [extracellular region]
Formation of hydroxyallysine by LOX (Bos taurus)
Lysyl oxidases:Cu2+ [extracellular region] (Bos taurus)
Cu2+ [extracellular region]
Elastic fibre formation (Bos taurus)
Elastin cross-linking by lysyl oxidase (Bos taurus)
Lysyl oxidases:Cu2+ [extracellular region] (Bos taurus)
Cu2+ [extracellular region]
Transport of small molecules (Bos taurus)
Iron uptake and transport (Bos taurus)
SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Bos taurus)
SLC40A1:CP:6Cu2+ [plasma membrane] (Bos taurus)
Cu2+ [extracellular region]
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Bos taurus)
SLC40A1:CP:6Cu2+ [plasma membrane] (Bos taurus)
Cu2+ [extracellular region]
SLC-mediated transmembrane transport (Bos taurus)
Transport of bile salts and organic acids, metal ions and amine compounds (Bos taurus)
Metal ion SLC transporters (Bos taurus)
SLC31A1 transports Cu2+ from extracellular region to cytosol (Bos taurus)
Cu2+ [extracellular region]
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Bos taurus)
SLC40A1:CP:6Cu2+ [plasma membrane] (Bos taurus)
Cu2+ [extracellular region]
Transport of small molecules (Caenorhabditis elegans)
SLC-mediated transmembrane transport (Caenorhabditis elegans)
Transport of bile salts and organic acids, metal ions and amine compounds (Caenorhabditis elegans)
Metal ion SLC transporters (Caenorhabditis elegans)
SLC31A1 transports Cu2+ from extracellular region to cytosol (Caenorhabditis elegans)
Cu2+ [extracellular region]
Cellular responses to stimuli (Canis familiaris)
Cellular responses to stress (Canis familiaris)
Cellular response to chemical stress (Canis familiaris)
Detoxification of Reactive Oxygen Species (Canis familiaris)
SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Canis familiaris)
SOD3 tetramer [extracellular region] (Canis familiaris)
SOD3:Cu2+:Zn2+ [extracellular region] (Canis familiaris)
Cu2+ [extracellular region]
Secretion of SOD3 (Canis familiaris)
SOD3 tetramer [extracellular region] (Canis familiaris)
SOD3:Cu2+:Zn2+ [extracellular region] (Canis familiaris)
Cu2+ [extracellular region]
Extracellular matrix organization (Canis familiaris)
Collagen formation (Canis familiaris)
Assembly of collagen fibrils and other multimeric structures (Canis familiaris)
Crosslinking of collagen fibrils (Canis familiaris)
Formation of allysine by LOX (Canis familiaris)
Lysyl oxidases:Cu2+ [extracellular region] (Canis familiaris)
Cu2+ [extracellular region]
Formation of hydroxyallysine by LOX (Canis familiaris)
Lysyl oxidases:Cu2+ [extracellular region] (Canis familiaris)
Cu2+ [extracellular region]
Elastic fibre formation (Canis familiaris)
Elastin cross-linking by lysyl oxidase (Canis familiaris)
Lysyl oxidases:Cu2+ [extracellular region] (Canis familiaris)
Cu2+ [extracellular region]
Transport of small molecules (Canis familiaris)
Ion channel transport (Canis familiaris)
Ion transport by P-type ATPases (Canis familiaris)
ATP7A transports cytosolic Cu2+ to extracellular region (Canis familiaris)
Cu2+ [extracellular region]
Iron uptake and transport (Canis familiaris)
SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Canis familiaris)
SLC40A1:CP:6Cu2+ [plasma membrane] (Canis familiaris)
Cu2+ [extracellular region]
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Canis familiaris)
SLC40A1:CP:6Cu2+ [plasma membrane] (Canis familiaris)
Cu2+ [extracellular region]
SLC-mediated transmembrane transport (Canis familiaris)
Transport of bile salts and organic acids, metal ions and amine compounds (Canis familiaris)
Metal ion SLC transporters (Canis familiaris)
SLC31A1 transports Cu2+ from extracellular region to cytosol (Canis familiaris)
Cu2+ [extracellular region]
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Canis familiaris)
SLC40A1:CP:6Cu2+ [plasma membrane] (Canis familiaris)
Cu2+ [extracellular region]
Cellular responses to stimuli (Danio rerio)
Cellular responses to stress (Danio rerio)
Cellular response to chemical stress (Danio rerio)
Detoxification of Reactive Oxygen Species (Danio rerio)
SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Danio rerio)
SOD3 tetramer [extracellular region] (Danio rerio)
SOD3:Cu2+:Zn2+ [extracellular region] (Danio rerio)
Cu2+ [extracellular region]
Secretion of SOD3 (Danio rerio)
SOD3 tetramer [extracellular region] (Danio rerio)
SOD3:Cu2+:Zn2+ [extracellular region] (Danio rerio)
Cu2+ [extracellular region]
Extracellular matrix organization (Danio rerio)
Collagen formation (Danio rerio)
Assembly of collagen fibrils and other multimeric structures (Danio rerio)
Crosslinking of collagen fibrils (Danio rerio)
Formation of allysine by LOX (Danio rerio)
Lysyl oxidases:Cu2+ [extracellular region] (Danio rerio)
Cu2+ [extracellular region]
Formation of hydroxyallysine by LOX (Danio rerio)
Lysyl oxidases:Cu2+ [extracellular region] (Danio rerio)
Cu2+ [extracellular region]
Transport of small molecules (Danio rerio)
Ion channel transport (Danio rerio)
Ion transport by P-type ATPases (Danio rerio)
ATP7A transports cytosolic Cu2+ to extracellular region (Danio rerio)
Cu2+ [extracellular region]
Iron uptake and transport (Danio rerio)
SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Danio rerio)
SLC40A1:CP:6Cu2+ [plasma membrane] (Danio rerio)
Cu2+ [extracellular region]
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Danio rerio)
SLC40A1:CP:6Cu2+ [plasma membrane] (Danio rerio)
Cu2+ [extracellular region]
SLC-mediated transmembrane transport (Danio rerio)
Transport of bile salts and organic acids, metal ions and amine compounds (Danio rerio)
Metal ion SLC transporters (Danio rerio)
SLC31A1 transports Cu2+ from extracellular region to cytosol (Danio rerio)
Cu2+ [extracellular region]
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Danio rerio)
SLC40A1:CP:6Cu2+ [plasma membrane] (Danio rerio)
Cu2+ [extracellular region]
Cellular responses to stimuli (Dictyostelium discoideum)
Cellular responses to stress (Dictyostelium discoideum)
Cellular response to chemical stress (Dictyostelium discoideum)
Detoxification of Reactive Oxygen Species (Dictyostelium discoideum)
SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Dictyostelium discoideum)
SOD3 tetramer [extracellular region] (Dictyostelium discoideum)
SOD3:Cu2+:Zn2+ [extracellular region] (Dictyostelium discoideum)
Cu2+ [extracellular region]
Secretion of SOD3 (Dictyostelium discoideum)
SOD3 tetramer [extracellular region] (Dictyostelium discoideum)
SOD3:Cu2+:Zn2+ [extracellular region] (Dictyostelium discoideum)
Cu2+ [extracellular region]
Transport of small molecules (Dictyostelium discoideum)
SLC-mediated transmembrane transport (Dictyostelium discoideum)
Transport of bile salts and organic acids, metal ions and amine compounds (Dictyostelium discoideum)
Metal ion SLC transporters (Dictyostelium discoideum)
SLC31A1 transports Cu2+ from extracellular region to cytosol (Dictyostelium discoideum)
Cu2+ [extracellular region]
Transport of small molecules (Drosophila melanogaster)
SLC-mediated transmembrane transport (Drosophila melanogaster)
Transport of bile salts and organic acids, metal ions and amine compounds (Drosophila melanogaster)
Metal ion SLC transporters (Drosophila melanogaster)
SLC31A1 transports Cu2+ from extracellular region to cytosol (Drosophila melanogaster)
Cu2+ [extracellular region]
Cellular responses to stimuli (Gallus gallus)
Cellular responses to stress (Gallus gallus)
Cellular response to chemical stress (Gallus gallus)
Detoxification of Reactive Oxygen Species (Gallus gallus)
SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Gallus gallus)
SOD3 tetramer [extracellular region] (Gallus gallus)
SOD3:Cu2+:Zn2+ [extracellular region] (Gallus gallus)
Cu2+ [extracellular region]
Secretion of SOD3 (Gallus gallus)
SOD3 tetramer [extracellular region] (Gallus gallus)
SOD3:Cu2+:Zn2+ [extracellular region] (Gallus gallus)
Cu2+ [extracellular region]
Extracellular matrix organization (Gallus gallus)
Collagen formation (Gallus gallus)
Assembly of collagen fibrils and other multimeric structures (Gallus gallus)
Crosslinking of collagen fibrils (Gallus gallus)
Formation of allysine by LOX (Gallus gallus)
Lysyl oxidases:Cu2+ [extracellular region] (Gallus gallus)
Cu2+ [extracellular region]
Formation of hydroxyallysine by LOX (Gallus gallus)
Lysyl oxidases:Cu2+ [extracellular region] (Gallus gallus)
Cu2+ [extracellular region]
Elastic fibre formation (Gallus gallus)
Elastin cross-linking by lysyl oxidase (Gallus gallus)
Lysyl oxidases:Cu2+ [extracellular region] (Gallus gallus)
Cu2+ [extracellular region]
Transport of small molecules (Gallus gallus)
Ion channel transport (Gallus gallus)
Ion transport by P-type ATPases (Gallus gallus)
ATP7A transports cytosolic Cu2+ to extracellular region (Gallus gallus)
Cu2+ [extracellular region]
Iron uptake and transport (Gallus gallus)
SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Gallus gallus)
SLC40A1:CP:6Cu2+ [plasma membrane] (Gallus gallus)
Cu2+ [extracellular region]
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Gallus gallus)
SLC40A1:CP:6Cu2+ [plasma membrane] (Gallus gallus)
Cu2+ [extracellular region]
SLC-mediated transmembrane transport (Gallus gallus)
Transport of bile salts and organic acids, metal ions and amine compounds (Gallus gallus)
Metal ion SLC transporters (Gallus gallus)
SLC31A1 transports Cu2+ from extracellular region to cytosol (Gallus gallus)
Cu2+ [extracellular region]
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Gallus gallus)
SLC40A1:CP:6Cu2+ [plasma membrane] (Gallus gallus)
Cu2+ [extracellular region]
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
Detoxification of Reactive Oxygen Species (Homo sapiens)
SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Homo sapiens)
SOD3 tetramer [extracellular region] (Homo sapiens)
SOD3:Cu2+:Zn2+ [extracellular region] (Homo sapiens)
Cu2+ [extracellular region]
Secretion of SOD3 (Homo sapiens)
SOD3 tetramer [extracellular region] (Homo sapiens)
SOD3:Cu2+:Zn2+ [extracellular region] (Homo sapiens)
Cu2+ [extracellular region]
Disease (Homo sapiens)
Disorders of transmembrane transporters (Homo sapiens)
SLC transporter disorders (Homo sapiens)
Defective CP causes aceruloplasminemia (ACERULOP) (Homo sapiens)
Defective CP does not oxidise Fe2+ to Fe3+ (Homo sapiens)
CP mutants:6xCu2+:SLC40A1 [plasma membrane] (Homo sapiens)
Cu2+ [extracellular region]
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) (Homo sapiens)
Defective SLC40A1 does not transport Fe2+ from cytosol to extracellular region (Homo sapiens)
SLC40A1 mutants:CP:6xCu2+ [plasma membrane] (Homo sapiens)
Cu2+ [extracellular region]
Extracellular matrix organization (Homo sapiens)
Collagen formation (Homo sapiens)
Assembly of collagen fibrils and other multimeric structures (Homo sapiens)
Crosslinking of collagen fibrils (Homo sapiens)
Formation of allysine by LOX (Homo sapiens)
Lysyl oxidases:Cu2+ [extracellular region] (Homo sapiens)
Cu2+ [extracellular region]
Formation of hydroxyallysine by LOX (Homo sapiens)
Lysyl oxidases:Cu2+ [extracellular region] (Homo sapiens)
Cu2+ [extracellular region]
Elastic fibre formation (Homo sapiens)
Elastin cross-linking by lysyl oxidase (Homo sapiens)
Lysyl oxidases:Cu2+ [extracellular region] (Homo sapiens)
Cu2+ [extracellular region]
Transport of small molecules (Homo sapiens)
Ion channel transport (Homo sapiens)
Ion transport by P-type ATPases (Homo sapiens)
ATP7A transports cytosolic Cu2+ to extracellular region (Homo sapiens)
Cu2+ [extracellular region]
Iron uptake and transport (Homo sapiens)
SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Homo sapiens)
SLC40A1:CP:6Cu2+ [plasma membrane] (Homo sapiens)
Cu2+ [extracellular region]
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Homo sapiens)
SLC40A1:CP:6Cu2+ [plasma membrane] (Homo sapiens)
Cu2+ [extracellular region]
SLC-mediated transmembrane transport (Homo sapiens)
Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
Metal ion SLC transporters (Homo sapiens)
SLC31A1 transports Cu2+ from extracellular region to cytosol (Homo sapiens)
Cu2+ [extracellular region]
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Homo sapiens)
SLC40A1:CP:6Cu2+ [plasma membrane] (Homo sapiens)
Cu2+ [extracellular region]
Cellular responses to stimuli (Mus musculus)
Cellular responses to stress (Mus musculus)
Cellular response to chemical stress (Mus musculus)
Detoxification of Reactive Oxygen Species (Mus musculus)
SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Mus musculus)
SOD3 tetramer [extracellular region] (Mus musculus)
SOD3:Cu2+:Zn2+ [extracellular region] (Mus musculus)
Cu2+ [extracellular region]
Secretion of SOD3 (Mus musculus)
SOD3 tetramer [extracellular region] (Mus musculus)
SOD3:Cu2+:Zn2+ [extracellular region] (Mus musculus)
Cu2+ [extracellular region]
Extracellular matrix organization (Mus musculus)
Collagen formation (Mus musculus)
Assembly of collagen fibrils and other multimeric structures (Mus musculus)
Crosslinking of collagen fibrils (Mus musculus)
Formation of allysine by LOX (Mus musculus)
Lysyl oxidases:Cu2+ [extracellular region] (Mus musculus)
Cu2+ [extracellular region]
Formation of hydroxyallysine by LOX (Mus musculus)
Lysyl oxidases:Cu2+ [extracellular region] (Mus musculus)
Cu2+ [extracellular region]
Elastic fibre formation (Mus musculus)
Elastin cross-linking by lysyl oxidase (Mus musculus)
Lysyl oxidases:Cu2+ [extracellular region] (Mus musculus)
Cu2+ [extracellular region]
Transport of small molecules (Mus musculus)
Ion channel transport (Mus musculus)
Ion transport by P-type ATPases (Mus musculus)
ATP7A transports cytosolic Cu2+ to extracellular region (Mus musculus)
Cu2+ [extracellular region]
Iron uptake and transport (Mus musculus)
SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Mus musculus)
SLC40A1:CP:6Cu2+ [plasma membrane] (Mus musculus)
Cu2+ [extracellular region]
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Mus musculus)
SLC40A1:CP:6Cu2+ [plasma membrane] (Mus musculus)
Cu2+ [extracellular region]
SLC-mediated transmembrane transport (Mus musculus)
Transport of bile salts and organic acids, metal ions and amine compounds (Mus musculus)
Metal ion SLC transporters (Mus musculus)
SLC31A1 transports Cu2+ from extracellular region to cytosol (Mus musculus)
Cu2+ [extracellular region]
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Mus musculus)
SLC40A1:CP:6Cu2+ [plasma membrane] (Mus musculus)
Cu2+ [extracellular region]
Transport of small molecules (Plasmodium falciparum)
SLC-mediated transmembrane transport (Plasmodium falciparum)
Transport of bile salts and organic acids, metal ions and amine compounds (Plasmodium falciparum)
Metal ion SLC transporters (Plasmodium falciparum)
SLC31A1 transports Cu2+ from extracellular region to cytosol (Plasmodium falciparum)
Cu2+ [extracellular region]
Cellular responses to stimuli (Rattus norvegicus)
Cellular responses to stress (Rattus norvegicus)
Cellular response to chemical stress (Rattus norvegicus)
Detoxification of Reactive Oxygen Species (Rattus norvegicus)
SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Rattus norvegicus)
SOD3 tetramer [extracellular region] (Rattus norvegicus)
SOD3:Cu2+:Zn2+ [extracellular region] (Rattus norvegicus)
Cu2+ [extracellular region]
Secretion of SOD3 (Rattus norvegicus)
SOD3 tetramer [extracellular region] (Rattus norvegicus)
SOD3:Cu2+:Zn2+ [extracellular region] (Rattus norvegicus)
Cu2+ [extracellular region]
Extracellular matrix organization (Rattus norvegicus)
Collagen formation (Rattus norvegicus)
Assembly of collagen fibrils and other multimeric structures (Rattus norvegicus)
Crosslinking of collagen fibrils (Rattus norvegicus)
Formation of allysine by LOX (Rattus norvegicus)
Lysyl oxidases:Cu2+ [extracellular region] (Rattus norvegicus)
Cu2+ [extracellular region]
Formation of hydroxyallysine by LOX (Rattus norvegicus)
Lysyl oxidases:Cu2+ [extracellular region] (Rattus norvegicus)
Cu2+ [extracellular region]
Elastic fibre formation (Rattus norvegicus)
Elastin cross-linking by lysyl oxidase (Rattus norvegicus)
Lysyl oxidases:Cu2+ [extracellular region] (Rattus norvegicus)
Cu2+ [extracellular region]
Transport of small molecules (Rattus norvegicus)
Ion channel transport (Rattus norvegicus)
Ion transport by P-type ATPases (Rattus norvegicus)
ATP7A transports cytosolic Cu2+ to extracellular region (Rattus norvegicus)
Cu2+ [extracellular region]
Iron uptake and transport (Rattus norvegicus)
SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Rattus norvegicus)
SLC40A1:CP:6Cu2+ [plasma membrane] (Rattus norvegicus)
Cu2+ [extracellular region]
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Rattus norvegicus)
SLC40A1:CP:6Cu2+ [plasma membrane] (Rattus norvegicus)
Cu2+ [extracellular region]
SLC-mediated transmembrane transport (Rattus norvegicus)
Transport of bile salts and organic acids, metal ions and amine compounds (Rattus norvegicus)
Metal ion SLC transporters (Rattus norvegicus)
SLC31A1 transports Cu2+ from extracellular region to cytosol (Rattus norvegicus)
Cu2+ [extracellular region]
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Rattus norvegicus)
SLC40A1:CP:6Cu2+ [plasma membrane] (Rattus norvegicus)
Cu2+ [extracellular region]
Cellular responses to stimuli (Saccharomyces cerevisiae)
Cellular responses to stress (Saccharomyces cerevisiae)
Cellular response to chemical stress (Saccharomyces cerevisiae)
Detoxification of Reactive Oxygen Species (Saccharomyces cerevisiae)
SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Saccharomyces cerevisiae)
SOD3 tetramer [extracellular region] (Saccharomyces cerevisiae)
SOD3:Cu2+:Zn2+ [extracellular region] (Saccharomyces cerevisiae)
Cu2+ [extracellular region]
Secretion of SOD3 (Saccharomyces cerevisiae)
SOD3 tetramer [extracellular region] (Saccharomyces cerevisiae)
SOD3:Cu2+:Zn2+ [extracellular region] (Saccharomyces cerevisiae)
Cu2+ [extracellular region]
Transport of small molecules (Saccharomyces cerevisiae)
SLC-mediated transmembrane transport (Saccharomyces cerevisiae)
Transport of bile salts and organic acids, metal ions and amine compounds (Saccharomyces cerevisiae)
Metal ion SLC transporters (Saccharomyces cerevisiae)
SLC31A1 transports Cu2+ from extracellular region to cytosol (Saccharomyces cerevisiae)
Cu2+ [extracellular region]
Cellular responses to stimuli (Schizosaccharomyces pombe)
Cellular responses to stress (Schizosaccharomyces pombe)
Cellular response to chemical stress (Schizosaccharomyces pombe)
Detoxification of Reactive Oxygen Species (Schizosaccharomyces pombe)
SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Schizosaccharomyces pombe)
SOD3 tetramer [extracellular region] (Schizosaccharomyces pombe)
SOD3:Cu2+:Zn2+ [extracellular region] (Schizosaccharomyces pombe)
Cu2+ [extracellular region]
Secretion of SOD3 (Schizosaccharomyces pombe)
SOD3 tetramer [extracellular region] (Schizosaccharomyces pombe)
SOD3:Cu2+:Zn2+ [extracellular region] (Schizosaccharomyces pombe)
Cu2+ [extracellular region]
Transport of small molecules (Schizosaccharomyces pombe)
SLC-mediated transmembrane transport (Schizosaccharomyces pombe)
Transport of bile salts and organic acids, metal ions and amine compounds (Schizosaccharomyces pombe)
Metal ion SLC transporters (Schizosaccharomyces pombe)
SLC31A1 transports Cu2+ from extracellular region to cytosol (Schizosaccharomyces pombe)
Cu2+ [extracellular region]
Cellular responses to stimuli (Sus scrofa)
Cellular responses to stress (Sus scrofa)
Cellular response to chemical stress (Sus scrofa)
Detoxification of Reactive Oxygen Species (Sus scrofa)
SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Sus scrofa)
SOD3 tetramer [extracellular region] (Sus scrofa)
SOD3:Cu2+:Zn2+ [extracellular region] (Sus scrofa)
Cu2+ [extracellular region]
Secretion of SOD3 (Sus scrofa)
SOD3 tetramer [extracellular region] (Sus scrofa)
SOD3:Cu2+:Zn2+ [extracellular region] (Sus scrofa)
Cu2+ [extracellular region]
Extracellular matrix organization (Sus scrofa)
Collagen formation (Sus scrofa)
Assembly of collagen fibrils and other multimeric structures (Sus scrofa)
Crosslinking of collagen fibrils (Sus scrofa)
Formation of allysine by LOX (Sus scrofa)
Lysyl oxidases:Cu2+ [extracellular region] (Sus scrofa)
Cu2+ [extracellular region]
Formation of hydroxyallysine by LOX (Sus scrofa)
Lysyl oxidases:Cu2+ [extracellular region] (Sus scrofa)
Cu2+ [extracellular region]
Elastic fibre formation (Sus scrofa)
Elastin cross-linking by lysyl oxidase (Sus scrofa)
Lysyl oxidases:Cu2+ [extracellular region] (Sus scrofa)
Cu2+ [extracellular region]
Transport of small molecules (Sus scrofa)
Ion channel transport (Sus scrofa)
Ion transport by P-type ATPases (Sus scrofa)
ATP7A transports cytosolic Cu2+ to extracellular region (Sus scrofa)
Cu2+ [extracellular region]
Iron uptake and transport (Sus scrofa)
SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Sus scrofa)
SLC40A1:CP:6Cu2+ [plasma membrane] (Sus scrofa)
Cu2+ [extracellular region]
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Sus scrofa)
SLC40A1:CP:6Cu2+ [plasma membrane] (Sus scrofa)
Cu2+ [extracellular region]
SLC-mediated transmembrane transport (Sus scrofa)
Transport of bile salts and organic acids, metal ions and amine compounds (Sus scrofa)
Metal ion SLC transporters (Sus scrofa)
SLC31A1 transports Cu2+ from extracellular region to cytosol (Sus scrofa)
Cu2+ [extracellular region]
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Sus scrofa)
SLC40A1:CP:6Cu2+ [plasma membrane] (Sus scrofa)
Cu2+ [extracellular region]
Cellular responses to stimuli (Xenopus tropicalis)
Cellular responses to stress (Xenopus tropicalis)
Cellular response to chemical stress (Xenopus tropicalis)
Detoxification of Reactive Oxygen Species (Xenopus tropicalis)
SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Xenopus tropicalis)
SOD3 tetramer [extracellular region] (Xenopus tropicalis)
SOD3:Cu2+:Zn2+ [extracellular region] (Xenopus tropicalis)
Cu2+ [extracellular region]
Secretion of SOD3 (Xenopus tropicalis)
SOD3 tetramer [extracellular region] (Xenopus tropicalis)
SOD3:Cu2+:Zn2+ [extracellular region] (Xenopus tropicalis)
Cu2+ [extracellular region]
Extracellular matrix organization (Xenopus tropicalis)
Collagen formation (Xenopus tropicalis)
Assembly of collagen fibrils and other multimeric structures (Xenopus tropicalis)
Crosslinking of collagen fibrils (Xenopus tropicalis)
Formation of allysine by LOX (Xenopus tropicalis)
Lysyl oxidases:Cu2+ [extracellular region] (Xenopus tropicalis)
Cu2+ [extracellular region]
Formation of hydroxyallysine by LOX (Xenopus tropicalis)
Lysyl oxidases:Cu2+ [extracellular region] (Xenopus tropicalis)
Cu2+ [extracellular region]
Transport of small molecules (Xenopus tropicalis)
Ion channel transport (Xenopus tropicalis)
Ion transport by P-type ATPases (Xenopus tropicalis)
ATP7A transports cytosolic Cu2+ to extracellular region (Xenopus tropicalis)
Cu2+ [extracellular region]
Iron uptake and transport (Xenopus tropicalis)
SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Xenopus tropicalis)
SLC40A1:CP:6Cu2+ [plasma membrane] (Xenopus tropicalis)
Cu2+ [extracellular region]
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Xenopus tropicalis)
SLC40A1:CP:6Cu2+ [plasma membrane] (Xenopus tropicalis)
Cu2+ [extracellular region]
SLC-mediated transmembrane transport (Xenopus tropicalis)
Transport of bile salts and organic acids, metal ions and amine compounds (Xenopus tropicalis)
Metal ion SLC transporters (Xenopus tropicalis)
SLC31A1 transports Cu2+ from extracellular region to cytosol (Xenopus tropicalis)
Cu2+ [extracellular region]
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Xenopus tropicalis)
SLC40A1:CP:6Cu2+ [plasma membrane] (Xenopus tropicalis)
Cu2+ [extracellular region]
External Reference Information
External Reference
copper(2+) [ChEBI:29036]
Participates
as a component of
Lysyl oxidases:Cu2+ [extracellular region] (Sus scrofa)
Lysyl oxidases:Cu2+ [extracellular region] (Rattus norvegicus)
Lysyl oxidases:Cu2+ [extracellular region] (Mus musculus)
Lysyl oxidases:Cu2+ [extracellular region] (Canis familiaris)
Lysyl oxidases:Cu2+ [extracellular region] (Danio rerio)
Lysyl oxidases:Cu2+ [extracellular region] (Gallus gallus)
Lysyl oxidases:Cu2+ [extracellular region] (Bos taurus)
Lysyl oxidases:Cu2+ [extracellular region] (Xenopus tropicalis)
Lysyl oxidases:Cu2+ [extracellular region] (Homo sapiens)
SLC40A1 mutants:CP:6xCu2+ [plasma membrane] (Homo sapiens)
SOD3:Cu2+:Zn2+ [extracellular region] (Homo sapiens)
SOD3:Cu2+:Zn2+ [extracellular region] (Danio rerio)
SOD3:Cu2+:Zn2+ [extracellular region] (Dictyostelium discoideum)
SOD3:Cu2+:Zn2+ [extracellular region] (Bos taurus)
SOD3:Cu2+:Zn2+ [extracellular region] (Saccharomyces cerevisiae)
SOD3:Cu2+:Zn2+ [extracellular region] (Gallus gallus)
SOD3:Cu2+:Zn2+ [extracellular region] (Mus musculus)
SOD3:Cu2+:Zn2+ [extracellular region] (Rattus norvegicus)
SOD3:Cu2+:Zn2+ [extracellular region] (Schizosaccharomyces pombe)
SOD3:Cu2+:Zn2+ [extracellular region] (Xenopus tropicalis)
SOD3:Cu2+:Zn2+ [extracellular region] (Canis familiaris)
SOD3:Cu2+:Zn2+ [extracellular region] (Sus scrofa)
SLC40A1:CP:6Cu2+ [plasma membrane] (Mus musculus)
SLC40A1:CP:6Cu2+ [plasma membrane] (Homo sapiens)
SLC40A1:CP:6Cu2+ [plasma membrane] (Sus scrofa)
SLC40A1:CP:6Cu2+ [plasma membrane] (Xenopus tropicalis)
SLC40A1:CP:6Cu2+ [plasma membrane] (Gallus gallus)
SLC40A1:CP:6Cu2+ [plasma membrane] (Rattus norvegicus)
SLC40A1:CP:6Cu2+ [plasma membrane] (Danio rerio)
SLC40A1:CP:6Cu2+ [plasma membrane] (Canis familiaris)
SLC40A1:CP:6Cu2+ [plasma membrane] (Bos taurus)
CP mutants:6xCu2+:SLC40A1 [plasma membrane] (Homo sapiens)
as an input of
SLC31A1 transports Cu2+ from extracellular region to cytosol (Homo sapiens)
SLC31A1 transports Cu2+ from extracellular region to cytosol (Mus musculus)
SLC31A1 transports Cu2+ from extracellular region to cytosol (Rattus norvegicus)
SLC31A1 transports Cu2+ from extracellular region to cytosol (Canis familiaris)
SLC31A1 transports Cu2+ from extracellular region to cytosol (Bos taurus)
SLC31A1 transports Cu2+ from extracellular region to cytosol (Sus scrofa)
SLC31A1 transports Cu2+ from extracellular region to cytosol (Danio rerio)
SLC31A1 transports Cu2+ from extracellular region to cytosol (Xenopus tropicalis)
SLC31A1 transports Cu2+ from extracellular region to cytosol (Gallus gallus)
SLC31A1 transports Cu2+ from extracellular region to cytosol (Drosophila melanogaster)
SLC31A1 transports Cu2+ from extracellular region to cytosol (Caenorhabditis elegans)
SLC31A1 transports Cu2+ from extracellular region to cytosol (Dictyostelium discoideum)
SLC31A1 transports Cu2+ from extracellular region to cytosol (Schizosaccharomyces pombe)
SLC31A1 transports Cu2+ from extracellular region to cytosol (Saccharomyces cerevisiae)
SLC31A1 transports Cu2+ from extracellular region to cytosol (Plasmodium falciparum)
as an output of
ATP7A transports cytosolic Cu2+ to extracellular region (Homo sapiens)
ATP7A transports cytosolic Cu2+ to extracellular region (Mus musculus)
ATP7A transports cytosolic Cu2+ to extracellular region (Rattus norvegicus)
ATP7A transports cytosolic Cu2+ to extracellular region (Canis familiaris)
ATP7A transports cytosolic Cu2+ to extracellular region (Sus scrofa)
ATP7A transports cytosolic Cu2+ to extracellular region (Danio rerio)
ATP7A transports cytosolic Cu2+ to extracellular region (Xenopus tropicalis)
ATP7A transports cytosolic Cu2+ to extracellular region (Gallus gallus)
Other forms of this molecule
Cu2+ [Golgi lumen]
Cu2+ [mitochondrial intermembrane space]
Cu2+ [melanosome membrane]
Cu2+ [cytosol]
Cu2+ [mitochondrial inner membrane]
Cross References
COMPOUND
C00070
HMDB Metabolite
HMDB0000657
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