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Neu5Ac [lysosomal lumen]
Stable Identifier
R-ALL-428639
Type
Chemical Compound [SimpleEntity]
Compartment
lysosomal lumen
Synonyms
SA, N-acetylneuraminic acid, sialic acid
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Rattus norvegicus
Sus scrofa
Xenopus tropicalis
Expand all
Metabolism (Bos taurus)
Metabolism of lipids (Bos taurus)
Sphingolipid metabolism (Bos taurus)
Glycosphingolipid metabolism (Bos taurus)
Glycosphingolipid catabolism (Bos taurus)
NEU1,4 hydrolyze PSAP(195-273):GM3:PE (Bos taurus)
Neu5Ac [lysosomal lumen]
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
Asparagine N-linked glycosylation (Bos taurus)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Bos taurus)
Synthesis of substrates in N-glycan biosythesis (Bos taurus)
Sialic acid metabolism (Bos taurus)
NEU1 hydrolyses Neu5Ac from glycoconjugates (Bos taurus)
Neu5Ac [lysosomal lumen]
NEU4 hydrolyses Neu5Ac from glycoconjugates (Bos taurus)
Neu5Ac [lysosomal lumen]
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Bos taurus)
Neu5Ac [lysosomal lumen]
Transport of small molecules (Bos taurus)
SLC-mediated transmembrane transport (Bos taurus)
Transport of inorganic cations/anions and amino acids/oligopeptides (Bos taurus)
Organic anion transporters (Bos taurus)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Bos taurus)
Neu5Ac [lysosomal lumen]
Metabolism of proteins (Caenorhabditis elegans)
Post-translational protein modification (Caenorhabditis elegans)
Asparagine N-linked glycosylation (Caenorhabditis elegans)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Caenorhabditis elegans)
Synthesis of substrates in N-glycan biosythesis (Caenorhabditis elegans)
Sialic acid metabolism (Caenorhabditis elegans)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Caenorhabditis elegans)
Neu5Ac [lysosomal lumen]
Transport of small molecules (Caenorhabditis elegans)
SLC-mediated transmembrane transport (Caenorhabditis elegans)
Transport of inorganic cations/anions and amino acids/oligopeptides (Caenorhabditis elegans)
Organic anion transporters (Caenorhabditis elegans)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Caenorhabditis elegans)
Neu5Ac [lysosomal lumen]
Metabolism (Canis familiaris)
Metabolism of lipids (Canis familiaris)
Sphingolipid metabolism (Canis familiaris)
Glycosphingolipid metabolism (Canis familiaris)
Glycosphingolipid catabolism (Canis familiaris)
NEU1,4 hydrolyze PSAP(195-273):GM3:PE (Canis familiaris)
Neu5Ac [lysosomal lumen]
Metabolism of proteins (Canis familiaris)
Post-translational protein modification (Canis familiaris)
Asparagine N-linked glycosylation (Canis familiaris)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Canis familiaris)
Synthesis of substrates in N-glycan biosythesis (Canis familiaris)
Sialic acid metabolism (Canis familiaris)
NEU1 hydrolyses Neu5Ac from glycoconjugates (Canis familiaris)
Neu5Ac [lysosomal lumen]
NEU4 hydrolyses Neu5Ac from glycoconjugates (Canis familiaris)
Neu5Ac [lysosomal lumen]
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Canis familiaris)
Neu5Ac [lysosomal lumen]
Transport of small molecules (Canis familiaris)
SLC-mediated transmembrane transport (Canis familiaris)
Transport of inorganic cations/anions and amino acids/oligopeptides (Canis familiaris)
Organic anion transporters (Canis familiaris)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Canis familiaris)
Neu5Ac [lysosomal lumen]
Metabolism of proteins (Danio rerio)
Post-translational protein modification (Danio rerio)
Asparagine N-linked glycosylation (Danio rerio)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Danio rerio)
Synthesis of substrates in N-glycan biosythesis (Danio rerio)
Sialic acid metabolism (Danio rerio)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Danio rerio)
Neu5Ac [lysosomal lumen]
Transport of small molecules (Danio rerio)
SLC-mediated transmembrane transport (Danio rerio)
Transport of inorganic cations/anions and amino acids/oligopeptides (Danio rerio)
Organic anion transporters (Danio rerio)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Danio rerio)
Neu5Ac [lysosomal lumen]
Metabolism of proteins (Dictyostelium discoideum)
Post-translational protein modification (Dictyostelium discoideum)
Asparagine N-linked glycosylation (Dictyostelium discoideum)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Dictyostelium discoideum)
Synthesis of substrates in N-glycan biosythesis (Dictyostelium discoideum)
Sialic acid metabolism (Dictyostelium discoideum)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Dictyostelium discoideum)
Neu5Ac [lysosomal lumen]
Transport of small molecules (Dictyostelium discoideum)
SLC-mediated transmembrane transport (Dictyostelium discoideum)
Transport of inorganic cations/anions and amino acids/oligopeptides (Dictyostelium discoideum)
Organic anion transporters (Dictyostelium discoideum)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Dictyostelium discoideum)
Neu5Ac [lysosomal lumen]
Metabolism of proteins (Drosophila melanogaster)
Post-translational protein modification (Drosophila melanogaster)
Asparagine N-linked glycosylation (Drosophila melanogaster)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Drosophila melanogaster)
Synthesis of substrates in N-glycan biosythesis (Drosophila melanogaster)
Sialic acid metabolism (Drosophila melanogaster)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Drosophila melanogaster)
Neu5Ac [lysosomal lumen]
Transport of small molecules (Drosophila melanogaster)
SLC-mediated transmembrane transport (Drosophila melanogaster)
Transport of inorganic cations/anions and amino acids/oligopeptides (Drosophila melanogaster)
Organic anion transporters (Drosophila melanogaster)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Drosophila melanogaster)
Neu5Ac [lysosomal lumen]
Metabolism (Gallus gallus)
Metabolism of lipids (Gallus gallus)
Sphingolipid metabolism (Gallus gallus)
Glycosphingolipid metabolism (Gallus gallus)
Glycosphingolipid catabolism (Gallus gallus)
NEU1,4 hydrolyze PSAP(195-273):GM3:PE (Gallus gallus)
Neu5Ac [lysosomal lumen]
Metabolism of proteins (Gallus gallus)
Post-translational protein modification (Gallus gallus)
Asparagine N-linked glycosylation (Gallus gallus)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Gallus gallus)
Synthesis of substrates in N-glycan biosythesis (Gallus gallus)
Sialic acid metabolism (Gallus gallus)
NEU4 hydrolyses Neu5Ac from glycoconjugates (Gallus gallus)
Neu5Ac [lysosomal lumen]
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Gallus gallus)
Neu5Ac [lysosomal lumen]
Transport of small molecules (Gallus gallus)
SLC-mediated transmembrane transport (Gallus gallus)
Transport of inorganic cations/anions and amino acids/oligopeptides (Gallus gallus)
Organic anion transporters (Gallus gallus)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Gallus gallus)
Neu5Ac [lysosomal lumen]
Disease (Homo sapiens)
Disorders of transmembrane transporters (Homo sapiens)
SLC transporter disorders (Homo sapiens)
Defective SLC17A5 causes Salla disease (SD) and ISSD (Homo sapiens)
Defective SLC17A5 does not cotransport Neu5Ac, H+ from lysosomal lumen to cytosol (Homo sapiens)
Neu5Ac [lysosomal lumen]
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Sphingolipid metabolism (Homo sapiens)
Glycosphingolipid metabolism (Homo sapiens)
Glycosphingolipid catabolism (Homo sapiens)
NEU1,4 hydrolyze PSAP(195-273):GM3:PE (Homo sapiens)
Neu5Ac [lysosomal lumen]
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
Sialic acid metabolism (Homo sapiens)
NEU1 hydrolyses Neu5Ac from glycoconjugates (Homo sapiens)
Neu5Ac [lysosomal lumen]
NEU4 hydrolyses Neu5Ac from glycoconjugates (Homo sapiens)
Neu5Ac [lysosomal lumen]
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Homo sapiens)
Neu5Ac [lysosomal lumen]
Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Transport of inorganic cations/anions and amino acids/oligopeptides (Homo sapiens)
Organic anion transporters (Homo sapiens)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Homo sapiens)
Neu5Ac [lysosomal lumen]
Metabolism (Mus musculus)
Metabolism of lipids (Mus musculus)
Sphingolipid metabolism (Mus musculus)
Glycosphingolipid metabolism (Mus musculus)
Glycosphingolipid catabolism (Mus musculus)
NEU1,4 hydrolyze PSAP(195-273):GM3:PE (Mus musculus)
Neu5Ac [lysosomal lumen]
Metabolism of proteins (Mus musculus)
Post-translational protein modification (Mus musculus)
Asparagine N-linked glycosylation (Mus musculus)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Mus musculus)
Synthesis of substrates in N-glycan biosythesis (Mus musculus)
Sialic acid metabolism (Mus musculus)
NEU1 hydrolyses Neu5Ac from glycoconjugates (Mus musculus)
Neu5Ac [lysosomal lumen]
NEU4 hydrolyses Neu5Ac from glycoconjugates (Mus musculus)
Neu5Ac [lysosomal lumen]
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Mus musculus)
Neu5Ac [lysosomal lumen]
Transport of small molecules (Mus musculus)
SLC-mediated transmembrane transport (Mus musculus)
Transport of inorganic cations/anions and amino acids/oligopeptides (Mus musculus)
Organic anion transporters (Mus musculus)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Mus musculus)
Neu5Ac [lysosomal lumen]
Metabolism (Rattus norvegicus)
Metabolism of lipids (Rattus norvegicus)
Sphingolipid metabolism (Rattus norvegicus)
Glycosphingolipid metabolism (Rattus norvegicus)
Glycosphingolipid catabolism (Rattus norvegicus)
NEU1,4 hydrolyze PSAP(195-273):GM3:PE (Rattus norvegicus)
Neu5Ac [lysosomal lumen]
Metabolism of proteins (Rattus norvegicus)
Post-translational protein modification (Rattus norvegicus)
Asparagine N-linked glycosylation (Rattus norvegicus)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Rattus norvegicus)
Synthesis of substrates in N-glycan biosythesis (Rattus norvegicus)
Sialic acid metabolism (Rattus norvegicus)
NEU1 hydrolyses Neu5Ac from glycoconjugates (Rattus norvegicus)
Neu5Ac [lysosomal lumen]
NEU4 hydrolyses Neu5Ac from glycoconjugates (Rattus norvegicus)
Neu5Ac [lysosomal lumen]
Metabolism (Sus scrofa)
Metabolism of lipids (Sus scrofa)
Sphingolipid metabolism (Sus scrofa)
Glycosphingolipid metabolism (Sus scrofa)
Glycosphingolipid catabolism (Sus scrofa)
NEU1,4 hydrolyze PSAP(195-273):GM3:PE (Sus scrofa)
Neu5Ac [lysosomal lumen]
Metabolism of proteins (Sus scrofa)
Post-translational protein modification (Sus scrofa)
Asparagine N-linked glycosylation (Sus scrofa)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Sus scrofa)
Synthesis of substrates in N-glycan biosythesis (Sus scrofa)
Sialic acid metabolism (Sus scrofa)
NEU1 hydrolyses Neu5Ac from glycoconjugates (Sus scrofa)
Neu5Ac [lysosomal lumen]
NEU4 hydrolyses Neu5Ac from glycoconjugates (Sus scrofa)
Neu5Ac [lysosomal lumen]
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Sus scrofa)
Neu5Ac [lysosomal lumen]
Transport of small molecules (Sus scrofa)
SLC-mediated transmembrane transport (Sus scrofa)
Transport of inorganic cations/anions and amino acids/oligopeptides (Sus scrofa)
Organic anion transporters (Sus scrofa)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Sus scrofa)
Neu5Ac [lysosomal lumen]
Metabolism of proteins (Xenopus tropicalis)
Post-translational protein modification (Xenopus tropicalis)
Asparagine N-linked glycosylation (Xenopus tropicalis)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Xenopus tropicalis)
Synthesis of substrates in N-glycan biosythesis (Xenopus tropicalis)
Sialic acid metabolism (Xenopus tropicalis)
NEU1 hydrolyses Neu5Ac from glycoconjugates (Xenopus tropicalis)
Neu5Ac [lysosomal lumen]
NEU4 hydrolyses Neu5Ac from glycoconjugates (Xenopus tropicalis)
Neu5Ac [lysosomal lumen]
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Xenopus tropicalis)
Neu5Ac [lysosomal lumen]
Transport of small molecules (Xenopus tropicalis)
SLC-mediated transmembrane transport (Xenopus tropicalis)
Transport of inorganic cations/anions and amino acids/oligopeptides (Xenopus tropicalis)
Organic anion transporters (Xenopus tropicalis)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Xenopus tropicalis)
Neu5Ac [lysosomal lumen]
External Reference Information
External Reference
N-acetylneuraminate [ChEBI:35418]
Participates
as an input of
Defective SLC17A5 does not cotransport Neu5Ac, H+ from lysosomal lumen to cytosol (Homo sapiens)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Dictyostelium discoideum)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Caenorhabditis elegans)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Drosophila melanogaster)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Gallus gallus)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Xenopus tropicalis)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Danio rerio)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Sus scrofa)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Bos taurus)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Canis familiaris)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Mus musculus)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Homo sapiens)
as an output of
NEU1,4 hydrolyze PSAP(195-273):GM3:PE (Gallus gallus)
NEU1,4 hydrolyze PSAP(195-273):GM3:PE (Sus scrofa)
NEU1,4 hydrolyze PSAP(195-273):GM3:PE (Bos taurus)
NEU1,4 hydrolyze PSAP(195-273):GM3:PE (Canis familiaris)
NEU1,4 hydrolyze PSAP(195-273):GM3:PE (Rattus norvegicus)
NEU1,4 hydrolyze PSAP(195-273):GM3:PE (Mus musculus)
NEU1,4 hydrolyze PSAP(195-273):GM3:PE (Homo sapiens)
NEU4 hydrolyses Neu5Ac from glycoconjugates (Gallus gallus)
NEU4 hydrolyses Neu5Ac from glycoconjugates (Xenopus tropicalis)
NEU4 hydrolyses Neu5Ac from glycoconjugates (Sus scrofa)
NEU4 hydrolyses Neu5Ac from glycoconjugates (Bos taurus)
NEU4 hydrolyses Neu5Ac from glycoconjugates (Canis familiaris)
NEU4 hydrolyses Neu5Ac from glycoconjugates (Rattus norvegicus)
NEU4 hydrolyses Neu5Ac from glycoconjugates (Mus musculus)
NEU4 hydrolyses Neu5Ac from glycoconjugates (Homo sapiens)
NEU1 hydrolyses Neu5Ac from glycoconjugates (Xenopus tropicalis)
NEU1 hydrolyses Neu5Ac from glycoconjugates (Sus scrofa)
NEU1 hydrolyses Neu5Ac from glycoconjugates (Bos taurus)
NEU1 hydrolyses Neu5Ac from glycoconjugates (Canis familiaris)
NEU1 hydrolyses Neu5Ac from glycoconjugates (Rattus norvegicus)
NEU1 hydrolyses Neu5Ac from glycoconjugates (Mus musculus)
NEU1 hydrolyses Neu5Ac from glycoconjugates (Homo sapiens)
Other forms of this molecule
Neu5Ac [nucleoplasm]
Neu5Ac [cytosol]
Cross References
ZINC
000003793840
,
000004081651
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