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ManNAc [cytosol]
Stable Identifier
R-ALL-4085214
Type
Chemical Compound [SimpleEntity]
Compartment
cytosol
Synonyms
N-acetyl-D-mannosamine, aldehydo-N-acetyl-D-mannosamine
Icon
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Canis familiaris
Danio rerio
Gallus gallus
Mus musculus
Rattus norvegicus
Sus scrofa
Xenopus tropicalis
Expand all
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
Asparagine N-linked glycosylation (Bos taurus)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Bos taurus)
Synthesis of substrates in N-glycan biosythesis (Bos taurus)
Sialic acid metabolism (Bos taurus)
GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Bos taurus)
ManNAc [cytosol]
GNE phosphorylates ManNAc to ManNAc-6-P (Bos taurus)
ManNAc [cytosol]
NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Bos taurus)
ManNAc,ManNGc [cytosol]
ManNAc [cytosol]
Synthesis of UDP-N-acetyl-glucosamine (Bos taurus)
RENBP isomerises ManNAc, ManNGc to GlcNAc, GlcNGc (Bos taurus)
ManNAc, ManNGc [cytosol]
ManNAc [cytosol]
Metabolism of proteins (Canis familiaris)
Post-translational protein modification (Canis familiaris)
Asparagine N-linked glycosylation (Canis familiaris)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Canis familiaris)
Synthesis of substrates in N-glycan biosythesis (Canis familiaris)
Sialic acid metabolism (Canis familiaris)
GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Canis familiaris)
ManNAc [cytosol]
GNE phosphorylates ManNAc to ManNAc-6-P (Canis familiaris)
ManNAc [cytosol]
NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Canis familiaris)
ManNAc,ManNGc [cytosol]
ManNAc [cytosol]
Metabolism of proteins (Danio rerio)
Post-translational protein modification (Danio rerio)
Asparagine N-linked glycosylation (Danio rerio)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Danio rerio)
Synthesis of substrates in N-glycan biosythesis (Danio rerio)
Sialic acid metabolism (Danio rerio)
GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Danio rerio)
ManNAc [cytosol]
GNE phosphorylates ManNAc to ManNAc-6-P (Danio rerio)
ManNAc [cytosol]
NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Danio rerio)
ManNAc,ManNGc [cytosol]
ManNAc [cytosol]
Metabolism of proteins (Gallus gallus)
Post-translational protein modification (Gallus gallus)
Asparagine N-linked glycosylation (Gallus gallus)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Gallus gallus)
Synthesis of substrates in N-glycan biosythesis (Gallus gallus)
Sialic acid metabolism (Gallus gallus)
GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Gallus gallus)
ManNAc [cytosol]
GNE phosphorylates ManNAc to ManNAc-6-P (Gallus gallus)
ManNAc [cytosol]
NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Gallus gallus)
ManNAc,ManNGc [cytosol]
ManNAc [cytosol]
Disease (Homo sapiens)
Diseases of metabolism (Homo sapiens)
Diseases of glycosylation (Homo sapiens)
Diseases associated with glycosylation precursor biosynthesis (Homo sapiens)
Defective GNE causes sialuria, NK and IBM2 (Homo sapiens)
Defective GNE does not phosphorylate ManNAc to ManNAc-6-P (Homo sapiens)
ManNAc [cytosol]
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
Sialic acid metabolism (Homo sapiens)
GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Homo sapiens)
ManNAc [cytosol]
GNE phosphorylates ManNAc to ManNAc-6-P (Homo sapiens)
ManNAc [cytosol]
NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Homo sapiens)
ManNAc,ManNGc [cytosol]
ManNAc [cytosol]
Synthesis of UDP-N-acetyl-glucosamine (Homo sapiens)
RENBP isomerises ManNAc, ManNGc to GlcNAc, GlcNGc (Homo sapiens)
ManNAc, ManNGc [cytosol]
ManNAc [cytosol]
Metabolism of proteins (Mus musculus)
Post-translational protein modification (Mus musculus)
Asparagine N-linked glycosylation (Mus musculus)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Mus musculus)
Synthesis of substrates in N-glycan biosythesis (Mus musculus)
Sialic acid metabolism (Mus musculus)
GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Mus musculus)
ManNAc [cytosol]
GNE phosphorylates ManNAc to ManNAc-6-P (Mus musculus)
ManNAc [cytosol]
NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Mus musculus)
ManNAc,ManNGc [cytosol]
ManNAc [cytosol]
Synthesis of UDP-N-acetyl-glucosamine (Mus musculus)
RENBP isomerises ManNAc, ManNGc to GlcNAc, GlcNGc (Mus musculus)
ManNAc, ManNGc [cytosol]
ManNAc [cytosol]
Metabolism of proteins (Rattus norvegicus)
Post-translational protein modification (Rattus norvegicus)
Asparagine N-linked glycosylation (Rattus norvegicus)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Rattus norvegicus)
Synthesis of substrates in N-glycan biosythesis (Rattus norvegicus)
Sialic acid metabolism (Rattus norvegicus)
GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Rattus norvegicus)
ManNAc [cytosol]
GNE phosphorylates ManNAc to ManNAc-6-P (Rattus norvegicus)
ManNAc [cytosol]
NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Rattus norvegicus)
ManNAc,ManNGc [cytosol]
ManNAc [cytosol]
Synthesis of UDP-N-acetyl-glucosamine (Rattus norvegicus)
RENBP isomerises ManNAc, ManNGc to GlcNAc, GlcNGc (Rattus norvegicus)
ManNAc, ManNGc [cytosol]
ManNAc [cytosol]
Metabolism of proteins (Sus scrofa)
Post-translational protein modification (Sus scrofa)
Asparagine N-linked glycosylation (Sus scrofa)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Sus scrofa)
Synthesis of substrates in N-glycan biosythesis (Sus scrofa)
Sialic acid metabolism (Sus scrofa)
GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Sus scrofa)
ManNAc [cytosol]
GNE phosphorylates ManNAc to ManNAc-6-P (Sus scrofa)
ManNAc [cytosol]
NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Sus scrofa)
ManNAc,ManNGc [cytosol]
ManNAc [cytosol]
Synthesis of UDP-N-acetyl-glucosamine (Sus scrofa)
RENBP isomerises ManNAc, ManNGc to GlcNAc, GlcNGc (Sus scrofa)
ManNAc, ManNGc [cytosol]
ManNAc [cytosol]
Metabolism of proteins (Xenopus tropicalis)
Post-translational protein modification (Xenopus tropicalis)
Asparagine N-linked glycosylation (Xenopus tropicalis)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Xenopus tropicalis)
Synthesis of substrates in N-glycan biosythesis (Xenopus tropicalis)
Sialic acid metabolism (Xenopus tropicalis)
GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Xenopus tropicalis)
ManNAc [cytosol]
GNE phosphorylates ManNAc to ManNAc-6-P (Xenopus tropicalis)
ManNAc [cytosol]
NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Xenopus tropicalis)
ManNAc,ManNGc [cytosol]
ManNAc [cytosol]
Synthesis of UDP-N-acetyl-glucosamine (Xenopus tropicalis)
RENBP isomerises ManNAc, ManNGc to GlcNAc, GlcNGc (Xenopus tropicalis)
ManNAc, ManNGc [cytosol]
ManNAc [cytosol]
External Reference Information
External Reference
aldehydo-N-acetyl-D-mannosamine [ChEBI:17122]
Participates
as an input of
Defective GNE does not phosphorylate ManNAc to ManNAc-6-P (Homo sapiens)
GNE phosphorylates ManNAc to ManNAc-6-P (Gallus gallus)
GNE phosphorylates ManNAc to ManNAc-6-P (Xenopus tropicalis)
GNE phosphorylates ManNAc to ManNAc-6-P (Danio rerio)
GNE phosphorylates ManNAc to ManNAc-6-P (Sus scrofa)
GNE phosphorylates ManNAc to ManNAc-6-P (Bos taurus)
GNE phosphorylates ManNAc to ManNAc-6-P (Canis familiaris)
GNE phosphorylates ManNAc to ManNAc-6-P (Rattus norvegicus)
GNE phosphorylates ManNAc to ManNAc-6-P (Mus musculus)
GNE phosphorylates ManNAc to ManNAc-6-P (Homo sapiens)
as an output of
GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Gallus gallus)
GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Xenopus tropicalis)
GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Danio rerio)
GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Sus scrofa)
GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Bos taurus)
GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Canis familiaris)
GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Rattus norvegicus)
GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Mus musculus)
GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Homo sapiens)
as a member of
ManNAc,ManNGc [cytosol]
ManNAc, ManNGc [cytosol]
Cross References
COMPOUND
C00645
ZINC
000013532465
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![ManNAc [cytosol] icon](/icon/R-ICO-013045.svg){kind=icon}
