Ligands of PPARA [nucleoplasm]

Stable Identifier
Set [DefinedSet]
Locations in the PathwayBrowser
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PPAR-alpha is most efficiently activated by polyunsaturated fatty acids having 18-20 carbon groups and 3-5 double bonds.

Literature References
PubMed ID Title Journal Year
17007889 Selectivity of fatty acid ligands for PPARalpha which correlates both with binding to cis-element and DNA binding-independent transactivity in Caco-2 cells

Mochizuki, K, Suruga, K, Fukami, H, Kiso, Y, Takase, S, Goda, T

Life Sci 2006
9171241 Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay

Krey, G, Braissant, O, L'Horset, F, Kalkhoven, E, Perroud, M, Parker, MG, Wahli, W

Mol Endocrinol 1997
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