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PGI2 [extracellular region]
Stable Identifier
R-ALL-391926
Type
Chemical Compound [SimpleEntity]
Compartment
extracellular region
Synonyms
Prostacyclin, prostaglandin I2, (5Z,13E)-(15S)-6,9alpha-Epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate
Icon
Locations in the PathwayBrowser
for Species:
Homo sapiens
Canis familiaris
Danio rerio
Drosophila melanogaster
Mus musculus
Rattus norvegicus
Sus scrofa
Xenopus tropicalis
Expand all
Hemostasis (Canis familiaris)
Platelet homeostasis (Canis familiaris)
Prostacyclin signalling through prostacyclin receptor (Canis familiaris)
Gs activation by prostacyclin receptor (Canis familiaris)
Prostacyclin:prostacyclin receptor:G-protein Gs (active) [plasma membrane] (Canis familiaris)
PTGIR:PGI2 [plasma membrane] (Canis familiaris)
PGI2 [extracellular region]
Prostacyclin:prostacyclin receptor:Gs (inactive) [plasma membrane] (Canis familiaris)
PTGIR:PGI2 [plasma membrane] (Canis familiaris)
PGI2 [extracellular region]
IP receptor can bind prostacyclin (Canis familiaris)
PGI2 [extracellular region]
PTGIR:PGI2 [plasma membrane] (Canis familiaris)
PGI2 [extracellular region]
Signal Transduction (Canis familiaris)
Signaling by GPCR (Canis familiaris)
GPCR downstream signalling (Canis familiaris)
G alpha (s) signalling events (Canis familiaris)
Liganded Gs-activating GPCR acts as a GEF for Gs (Canis familiaris)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Canis familiaris)
PTGIR:PGI2 [plasma membrane] (Canis familiaris)
PGI2 [extracellular region]
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Canis familiaris)
PTGIR:PGI2 [plasma membrane] (Canis familiaris)
PGI2 [extracellular region]
GPCR ligand binding (Canis familiaris)
Class A/1 (Rhodopsin-like receptors) (Canis familiaris)
Eicosanoid ligand-binding receptors (Canis familiaris)
Prostanoid ligand receptors (Canis familiaris)
IP receptor can bind prostacyclin (Canis familiaris)
PGI2 [extracellular region]
PTGIR:PGI2 [plasma membrane] (Canis familiaris)
PGI2 [extracellular region]
Hemostasis (Danio rerio)
Platelet homeostasis (Danio rerio)
Prostacyclin signalling through prostacyclin receptor (Danio rerio)
Gs activation by prostacyclin receptor (Danio rerio)
Prostacyclin:prostacyclin receptor:G-protein Gs (active) [plasma membrane] (Danio rerio)
PTGIR:PGI2 [plasma membrane] (Danio rerio)
PGI2 [extracellular region]
Prostacyclin:prostacyclin receptor:Gs (inactive) [plasma membrane] (Danio rerio)
PTGIR:PGI2 [plasma membrane] (Danio rerio)
PGI2 [extracellular region]
IP receptor can bind prostacyclin (Danio rerio)
PGI2 [extracellular region]
PTGIR:PGI2 [plasma membrane] (Danio rerio)
PGI2 [extracellular region]
Signal Transduction (Danio rerio)
Signaling by GPCR (Danio rerio)
GPCR downstream signalling (Danio rerio)
G alpha (s) signalling events (Danio rerio)
Liganded Gs-activating GPCR acts as a GEF for Gs (Danio rerio)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Danio rerio)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Danio rerio)
PTGIR:PGI2 [plasma membrane] (Danio rerio)
PGI2 [extracellular region]
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Danio rerio)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Danio rerio)
PTGIR:PGI2 [plasma membrane] (Danio rerio)
PGI2 [extracellular region]
GPCR ligand binding (Danio rerio)
Class A/1 (Rhodopsin-like receptors) (Danio rerio)
Eicosanoid ligand-binding receptors (Danio rerio)
Prostanoid ligand receptors (Danio rerio)
IP receptor can bind prostacyclin (Danio rerio)
PGI2 [extracellular region]
PTGIR:PGI2 [plasma membrane] (Danio rerio)
PGI2 [extracellular region]
Hemostasis (Drosophila melanogaster)
Platelet homeostasis (Drosophila melanogaster)
Prostacyclin signalling through prostacyclin receptor (Drosophila melanogaster)
Gs activation by prostacyclin receptor (Drosophila melanogaster)
Prostacyclin:prostacyclin receptor:G-protein Gs (active) [plasma membrane] (Drosophila melanogaster)
PTGIR:PGI2 [plasma membrane] (Drosophila melanogaster)
PGI2 [extracellular region]
Prostacyclin:prostacyclin receptor:Gs (inactive) [plasma membrane] (Drosophila melanogaster)
PTGIR:PGI2 [plasma membrane] (Drosophila melanogaster)
PGI2 [extracellular region]
IP receptor can bind prostacyclin (Drosophila melanogaster)
PGI2 [extracellular region]
PTGIR:PGI2 [plasma membrane] (Drosophila melanogaster)
PGI2 [extracellular region]
Signal Transduction (Drosophila melanogaster)
Signaling by GPCR (Drosophila melanogaster)
GPCR downstream signalling (Drosophila melanogaster)
G alpha (s) signalling events (Drosophila melanogaster)
Liganded Gs-activating GPCR acts as a GEF for Gs (Drosophila melanogaster)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Drosophila melanogaster)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Drosophila melanogaster)
PTGIR:PGI2 [plasma membrane] (Drosophila melanogaster)
PGI2 [extracellular region]
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Drosophila melanogaster)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Drosophila melanogaster)
PTGIR:PGI2 [plasma membrane] (Drosophila melanogaster)
PGI2 [extracellular region]
GPCR ligand binding (Drosophila melanogaster)
Class A/1 (Rhodopsin-like receptors) (Drosophila melanogaster)
Eicosanoid ligand-binding receptors (Drosophila melanogaster)
Prostanoid ligand receptors (Drosophila melanogaster)
IP receptor can bind prostacyclin (Drosophila melanogaster)
PGI2 [extracellular region]
PTGIR:PGI2 [plasma membrane] (Drosophila melanogaster)
PGI2 [extracellular region]
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Leishmania infection (Homo sapiens)
Leishmania parasite growth and survival (Homo sapiens)
Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
ADORA2B mediated anti-inflammatory cytokines production (Homo sapiens)
ADORA2B (in Ade-Rib:ADORA2B:Heterotrimeric G-protein Gs) exchanges GDP for GTP on Gs (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
PTGIR:PGI2 [plasma membrane] (Homo sapiens)
PGI2 [extracellular region]
Hemostasis (Homo sapiens)
Platelet homeostasis (Homo sapiens)
Prostacyclin signalling through prostacyclin receptor (Homo sapiens)
Activated prostacyclin receptor binds G-protein Gs (Homo sapiens)
PTGIR:PGI2 [plasma membrane] (Homo sapiens)
PGI2 [extracellular region]
Prostacyclin:prostacyclin receptor:Gs (inactive) [plasma membrane] (Homo sapiens)
PTGIR:PGI2 [plasma membrane] (Homo sapiens)
PGI2 [extracellular region]
Dissociation of the Prostacyclin receptor:Gs complex (Homo sapiens)
PGI2 [extracellular region]
Prostacyclin:prostacyclin receptor:G-protein Gs (active) [plasma membrane] (Homo sapiens)
PTGIR:PGI2 [plasma membrane] (Homo sapiens)
PGI2 [extracellular region]
Gs activation by prostacyclin receptor (Homo sapiens)
Prostacyclin:prostacyclin receptor:G-protein Gs (active) [plasma membrane] (Homo sapiens)
PTGIR:PGI2 [plasma membrane] (Homo sapiens)
PGI2 [extracellular region]
Prostacyclin:prostacyclin receptor:Gs (inactive) [plasma membrane] (Homo sapiens)
PTGIR:PGI2 [plasma membrane] (Homo sapiens)
PGI2 [extracellular region]
IP receptor can bind prostacyclin (Homo sapiens)
PGI2 [extracellular region]
PTGIR:PGI2 [plasma membrane] (Homo sapiens)
PGI2 [extracellular region]
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
PTGIR:PGI2 [plasma membrane] (Homo sapiens)
PGI2 [extracellular region]
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
PTGIR:PGI2 [plasma membrane] (Homo sapiens)
PGI2 [extracellular region]
Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
PTGIR:PGI2 [plasma membrane] (Homo sapiens)
PGI2 [extracellular region]
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
PTGIR:PGI2 [plasma membrane] (Homo sapiens)
PGI2 [extracellular region]
The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
PTGIR:PGI2 [plasma membrane] (Homo sapiens)
PGI2 [extracellular region]
Ligands of GPCRs that activate Gs [extracellular region] (Homo sapiens)
PGI2 [extracellular region]
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Eicosanoid ligand-binding receptors (Homo sapiens)
Prostanoid ligand receptors (Homo sapiens)
IP receptor can bind prostacyclin (Homo sapiens)
PGI2 [extracellular region]
PTGIR:PGI2 [plasma membrane] (Homo sapiens)
PGI2 [extracellular region]
Hemostasis (Mus musculus)
Platelet homeostasis (Mus musculus)
Prostacyclin signalling through prostacyclin receptor (Mus musculus)
Gs activation by prostacyclin receptor (Mus musculus)
Prostacyclin:prostacyclin receptor:G-protein Gs (active) [plasma membrane] (Mus musculus)
PTGIR:PGI2 [plasma membrane] (Mus musculus)
PGI2 [extracellular region]
Prostacyclin:prostacyclin receptor:Gs (inactive) [plasma membrane] (Mus musculus)
PTGIR:PGI2 [plasma membrane] (Mus musculus)
PGI2 [extracellular region]
IP receptor can bind prostacyclin (Mus musculus)
PGI2 [extracellular region]
PTGIR:PGI2 [plasma membrane] (Mus musculus)
PGI2 [extracellular region]
Signal Transduction (Mus musculus)
Signaling by GPCR (Mus musculus)
GPCR downstream signalling (Mus musculus)
G alpha (s) signalling events (Mus musculus)
Liganded Gs-activating GPCR acts as a GEF for Gs (Mus musculus)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Mus musculus)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Mus musculus)
PTGIR:PGI2 [plasma membrane] (Mus musculus)
PGI2 [extracellular region]
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Mus musculus)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Mus musculus)
PTGIR:PGI2 [plasma membrane] (Mus musculus)
PGI2 [extracellular region]
GPCR ligand binding (Mus musculus)
Class A/1 (Rhodopsin-like receptors) (Mus musculus)
Eicosanoid ligand-binding receptors (Mus musculus)
Prostanoid ligand receptors (Mus musculus)
IP receptor can bind prostacyclin (Mus musculus)
PGI2 [extracellular region]
PTGIR:PGI2 [plasma membrane] (Mus musculus)
PGI2 [extracellular region]
Hemostasis (Rattus norvegicus)
Platelet homeostasis (Rattus norvegicus)
Prostacyclin signalling through prostacyclin receptor (Rattus norvegicus)
IP receptor can bind prostacyclin (Rattus norvegicus)
PGI2 [extracellular region]
PTGIR:PGI2 [plasma membrane] (Rattus norvegicus)
PGI2 [extracellular region]
Signal Transduction (Rattus norvegicus)
Signaling by GPCR (Rattus norvegicus)
GPCR ligand binding (Rattus norvegicus)
Class A/1 (Rhodopsin-like receptors) (Rattus norvegicus)
Eicosanoid ligand-binding receptors (Rattus norvegicus)
Prostanoid ligand receptors (Rattus norvegicus)
IP receptor can bind prostacyclin (Rattus norvegicus)
PGI2 [extracellular region]
PTGIR:PGI2 [plasma membrane] (Rattus norvegicus)
PGI2 [extracellular region]
Hemostasis (Sus scrofa)
Platelet homeostasis (Sus scrofa)
Prostacyclin signalling through prostacyclin receptor (Sus scrofa)
Gs activation by prostacyclin receptor (Sus scrofa)
Prostacyclin:prostacyclin receptor:G-protein Gs (active) [plasma membrane] (Sus scrofa)
PTGIR:PGI2 [plasma membrane] (Sus scrofa)
PGI2 [extracellular region]
Prostacyclin:prostacyclin receptor:Gs (inactive) [plasma membrane] (Sus scrofa)
PTGIR:PGI2 [plasma membrane] (Sus scrofa)
PGI2 [extracellular region]
IP receptor can bind prostacyclin (Sus scrofa)
PGI2 [extracellular region]
PTGIR:PGI2 [plasma membrane] (Sus scrofa)
PGI2 [extracellular region]
Signal Transduction (Sus scrofa)
Signaling by GPCR (Sus scrofa)
GPCR downstream signalling (Sus scrofa)
G alpha (s) signalling events (Sus scrofa)
Liganded Gs-activating GPCR acts as a GEF for Gs (Sus scrofa)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Sus scrofa)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Sus scrofa)
PTGIR:PGI2 [plasma membrane] (Sus scrofa)
PGI2 [extracellular region]
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Sus scrofa)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Sus scrofa)
PTGIR:PGI2 [plasma membrane] (Sus scrofa)
PGI2 [extracellular region]
GPCR ligand binding (Sus scrofa)
Class A/1 (Rhodopsin-like receptors) (Sus scrofa)
Eicosanoid ligand-binding receptors (Sus scrofa)
Prostanoid ligand receptors (Sus scrofa)
IP receptor can bind prostacyclin (Sus scrofa)
PGI2 [extracellular region]
PTGIR:PGI2 [plasma membrane] (Sus scrofa)
PGI2 [extracellular region]
Hemostasis (Xenopus tropicalis)
Platelet homeostasis (Xenopus tropicalis)
Prostacyclin signalling through prostacyclin receptor (Xenopus tropicalis)
Gs activation by prostacyclin receptor (Xenopus tropicalis)
Prostacyclin:prostacyclin receptor:G-protein Gs (active) [plasma membrane] (Xenopus tropicalis)
PTGIR:PGI2 [plasma membrane] (Xenopus tropicalis)
PGI2 [extracellular region]
Prostacyclin:prostacyclin receptor:Gs (inactive) [plasma membrane] (Xenopus tropicalis)
PTGIR:PGI2 [plasma membrane] (Xenopus tropicalis)
PGI2 [extracellular region]
IP receptor can bind prostacyclin (Xenopus tropicalis)
PGI2 [extracellular region]
PTGIR:PGI2 [plasma membrane] (Xenopus tropicalis)
PGI2 [extracellular region]
Signal Transduction (Xenopus tropicalis)
Signaling by GPCR (Xenopus tropicalis)
GPCR downstream signalling (Xenopus tropicalis)
G alpha (s) signalling events (Xenopus tropicalis)
Liganded Gs-activating GPCR acts as a GEF for Gs (Xenopus tropicalis)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Xenopus tropicalis)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Xenopus tropicalis)
PTGIR:PGI2 [plasma membrane] (Xenopus tropicalis)
PGI2 [extracellular region]
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Xenopus tropicalis)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Xenopus tropicalis)
PTGIR:PGI2 [plasma membrane] (Xenopus tropicalis)
PGI2 [extracellular region]
GPCR ligand binding (Xenopus tropicalis)
Class A/1 (Rhodopsin-like receptors) (Xenopus tropicalis)
Eicosanoid ligand-binding receptors (Xenopus tropicalis)
Prostanoid ligand receptors (Xenopus tropicalis)
IP receptor can bind prostacyclin (Xenopus tropicalis)
PGI2 [extracellular region]
PTGIR:PGI2 [plasma membrane] (Xenopus tropicalis)
PGI2 [extracellular region]
External Reference Information
External Reference
prostaglandin I2 [ChEBI:15552]
Participant Of
output
Dissociation of the Prostacyclin receptor:Gs complex
input
IP receptor can bind prostacyclin
IP receptor can bind prostacyclin
IP receptor can bind prostacyclin
IP receptor can bind prostacyclin
IP receptor can bind prostacyclin
IP receptor can bind prostacyclin
IP receptor can bind prostacyclin
IP receptor can bind prostacyclin
hasMember
Ligands of GPCRs that activate Gs [extracellular region]
hasComponent
PTGIR:PGI2 [plasma membrane]
PTGIR:PGI2 [plasma membrane]
PTGIR:PGI2 [plasma membrane]
PTGIR:PGI2 [plasma membrane]
PTGIR:PGI2 [plasma membrane]
PTGIR:PGI2 [plasma membrane]
PTGIR:PGI2 [plasma membrane]
PTGIR:PGI2 [plasma membrane]
Other forms of this molecule
PGI2 [endoplasmic reticulum lumen]
Cross References
COMPOUND
C01312
PubChem Substance
8143216
HMDB Metabolite
HMDB0001335
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